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Q7NIG8

- GLMS_GLOVI

UniProt

Q7NIG8 - GLMS_GLOVI

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei604 – 6041For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-2242-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:gll2215
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
ProteomesiUP000000557: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 609608Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135336Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi251221.gll2215.

Structurei

3D structure databases

ProteinModelPortaliQ7NIG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 219218Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini285 – 424140SIS 1UniRule annotationAdd
BLAST
Domaini458 – 599142SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
InParanoidiQ7NIG8.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.
PhylomeDBiQ7NIG8.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7NIG8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIVGYIGG RTALPFLVDG LKRLEYRGYD SAGIATVGES GLELVRAKGK
60 70 80 90 100
LHNLEEKLNG VAQSTGTVGI GHTRWATHGK PEEHNAHPHT DASGRLAVIQ
110 120 130 140 150
NGIIENYAEL RLGLKERGCL FKSETDTEVI PHLIACRLAG HSLLEAVLAA
160 170 180 190 200
VVELKGAFAI AVVSADFPDE LIVVRQQAPL VIGFGEGENY FASDVPAIVS
210 220 230 240 250
HTTRVLTLQD GECARLTRDE VQIHDFSGAR LRRTPRSLNW NPSLVEKRGF
260 270 280 290 300
RHFMLKEIHE QPGVIRDTLE DRIGDATGPI RLGLSSDLFA DLERIYIIAC
310 320 330 340 350
GTSWHASLVG KYLIEELAGI PTEVNYASEF RYCPPPLNAR TLVIGVSQSG
360 370 380 390 400
ETGDTNAALT AAKARGVRLL GITNRPESSL GALVGELIDT RAGMEIGVAA
410 420 430 440 450
TKTFTAQLVA FYLLALHLAH LRGTQSGERI REILVGLQQL PAQIEGILDT
460 470 480 490 500
QERYITELAR EFDATRDFIF IGRGLNYPIA LEGALKLKEI SYIHAEGYPA
510 520 530 540 550
GEMKHGPIAL LDSEVPVVAI AVPGKVYEKT LSNAQEAKAR DARLIGVAPL
560 570 580 590 600
DEPAAVETFD QILPVPVVDE ILSPILTVVP LQLLAYHIAA RRGLDVDQPR

NLAKSVTVE
Length:609
Mass (Da):66,042
Last modified:January 23, 2007 - v3
Checksum:i9BCA4BC0DF7DFA2F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC90156.1.
RefSeqiNP_925161.1. NC_005125.1.
WP_011142212.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC90156; BAC90156; BAC90156.
GeneIDi2600617.
KEGGigvi:gll2215.
PATRICi22043893. VBIGloVio86258_2249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC90156.1 .
RefSeqi NP_925161.1. NC_005125.1.
WP_011142212.1. NC_005125.1.

3D structure databases

ProteinModelPortali Q7NIG8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 251221.gll2215.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC90156 ; BAC90156 ; BAC90156 .
GeneIDi 2600617.
KEGGi gvi:gll2215.
PATRICi 22043893. VBIGloVio86258_2249.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
InParanoidi Q7NIG8.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.
PhylomeDBi Q7NIG8.

Enzyme and pathway databases

BioCyci GVIO251221:GH9A-2242-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7421.

Entry informationi

Entry nameiGLMS_GLOVI
AccessioniPrimary (citable) accession number: Q7NIG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3