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Protein

Peptide deformylase 2

Gene

def2

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi107IronUniRule annotation1
Metal bindingi149IronUniRule annotation1
Active sitei150UniRule annotation1
Metal bindingi153IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processProtein biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciGVIO251221:G1G3K-2255-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase 2UniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDF 2UniRule annotation
Alternative name(s):
Polypeptide deformylase 2UniRule annotation
Gene namesi
Name:def2UniRule annotation
Ordered Locus Names:gll2228
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacteraceaeGloeobacter
Proteomesi
  • UP000000557 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000827861 – 187Peptide deformylase 2Add BLAST187

Proteomic databases

PRIDEiQ7NIF5

Interactioni

Protein-protein interaction databases

STRINGi251221.gll2228

Structurei

3D structure databases

ProteinModelPortaliQ7NIF5
SMRiQ7NIF5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z02 Bacteria
COG0242 LUCA
HOGENOMiHOG000243509
InParanoidiQ7NIF5
KOiK01462
OMAiVCIQHEI
OrthoDBiPOG091H02B0
PhylomeDBiQ7NIF5

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.10, 1 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit
TIGRFAMsiTIGR00079 pept_deformyl, 1 hit

Sequencei

Sequence statusi: Complete.

Q7NIF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANQLQVPKQ KLAKPPLAIH TLGDRVLRQG SKQISGINDE VRKLAQQMLQ
60 70 80 90 100
TMYSADGIGL AAPQVGVNKR MIVVDIDPEN AARPPLVLIN PLIKQFSSDL
110 120 130 140 150
AVDQEGCLSV PSIYADVRRP ERVVATYRDL NGRPVTLEAT GLLARCIQHE
160 170 180
IDHLDGVLFV DRVENQIALA PQLVEKGFAV RDVQVRA
Length:187
Mass (Da):20,557
Last modified:December 15, 2003 - v1
Checksum:i639E147377AAD007
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA Translation: BAC90169.1
RefSeqiNP_925174.1, NC_005125.1
WP_011142225.1, NC_005125.1

Genome annotation databases

EnsemblBacteriaiBAC90169; BAC90169; BAC90169
GeneIDi2600630
KEGGigvi:gll2228
PATRICifig|251221.4.peg.2260

Similar proteinsi

Entry informationi

Entry nameiDEF2_GLOVI
AccessioniPrimary (citable) accession number: Q7NIF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health