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Q7NI06

- SYE_GLOVI

UniProt

Q7NI06 - SYE_GLOVI

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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei270 – 2701ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-2407-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:gll2378
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
ProteomesiUP000000557: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Glutamate--tRNA ligasePRO_0000119568Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi251221.gvip330.

Structurei

3D structure databases

ProteinModelPortaliQ7NI06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi26 – 3611"HIGH" regionAdd
BLAST
Motifi267 – 2715"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0008.
InParanoidiQ7NI06.
KOiK01885.
OMAiAFEGPYF.
OrthoDBiEOG6DRPF7.
PhylomeDBiQ7NI06.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 2 hits.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7NI06 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNFEQYESAY PPRALPPGAW VTRIGPSPTG KAHIGTALQA VINRSLADGS
60 70 80 90 100
GGAFLLRIED TDRERFVEGA IEDLLAALDW LGIRPDESVA HGGAYGPYVQ
110 120 130 140 150
SERLPIYQAA ARQLVEVGHA YYCFCTPERL ESVRMAQQAA GKPTMYDRHC
160 170 180 190 200
RNLGREEVEK RLATGEKAVV RLKVPDGTEI AFDDLARGRI AFESQTIDDS
210 220 230 240 250
VLLKSDGFPT YHLAVVVDDH LMRVNQIIRG EEWIPSTPKH VLLYQYFGWP
260 270 280 290 300
MPRIAHTPIL RDMSRRKLSK RSGDTSITGY RVQGYLPEGL RNFLTRIIWP
310 320 330 340 350
HPEGKDVYDH EEFVRLFKAE DLPNTGPIVD PQLLDFINGQ YLRRLSSAEL
360 370 380 390 400
YTATVEYLKF LLGLHQDIIF ETYHPSAPIK QTLTRAELGS FYSAFTANPT
410 420 430 440 450
YTERVLTLEP ERYKRLSDIV VSTGFFFPAL FTPADPKLLA KPLGSPEKAG
460 470 480 490 500
ALLGEYLRLY RPDAAQAEWE QSVRELAHEA GVKDGKLFMT LRVAVTGREQ
510 520 530
TPPLFEVLTI LGGDEVQRRL ELAAAMPVSL
Length:530
Mass (Da):59,558
Last modified:December 15, 2003 - v1
Checksum:iB9F8B474FD8F7FF9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC90319.1.
RefSeqiNP_925324.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC90319; BAC90319; BAC90319.
GeneIDi2600779.
KEGGigvi:gvip330.
PATRICi22044233. VBIGloVio86258_2417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC90319.1 .
RefSeqi NP_925324.1. NC_005125.1.

3D structure databases

ProteinModelPortali Q7NI06.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 251221.gvip330.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC90319 ; BAC90319 ; BAC90319 .
GeneIDi 2600779.
KEGGi gvi:gvip330.
PATRICi 22044233. VBIGloVio86258_2417.

Phylogenomic databases

eggNOGi COG0008.
InParanoidi Q7NI06.
KOi K01885.
OMAi AFEGPYF.
OrthoDBi EOG6DRPF7.
PhylomeDBi Q7NI06.

Enzyme and pathway databases

BioCyci GVIO251221:GH9A-2407-MONOMER.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_B. Glu_tRNA_synth_B.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF48163. SSF48163. 2 hits.
TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7421.

Entry informationi

Entry nameiSYE_GLOVI
AccessioniPrimary (citable) accession number: Q7NI06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3