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Q7NI06

- SYE_GLOVI

UniProt

Q7NI06 - SYE_GLOVI

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei270 – 2701ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
    3. tRNA binding Source: InterPro

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciGVIO251221:GH9A-2407-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetaseUniRule annotation
    Short name:
    GluRSUniRule annotation
    Gene namesi
    Name:gltXUniRule annotation
    Ordered Locus Names:gll2378
    OrganismiGloeobacter violaceus (strain PCC 7421)
    Taxonomic identifieri251221 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
    ProteomesiUP000000557: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 530530Glutamate--tRNA ligasePRO_0000119568Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi251221.gvip330.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7NI06.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi26 – 3611"HIGH" regionAdd
    BLAST
    Motifi267 – 2715"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    KOiK01885.
    OMAiAFEGPYF.
    OrthoDBiEOG6DRPF7.
    PhylomeDBiQ7NI06.

    Family and domain databases

    Gene3Di1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_B. Glu_tRNA_synth_B.
    InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF48163. SSF48163. 2 hits.
    TIGRFAMsiTIGR00464. gltX_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7NI06-1 [UniParc]FASTAAdd to Basket

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    MNFEQYESAY PPRALPPGAW VTRIGPSPTG KAHIGTALQA VINRSLADGS    50
    GGAFLLRIED TDRERFVEGA IEDLLAALDW LGIRPDESVA HGGAYGPYVQ 100
    SERLPIYQAA ARQLVEVGHA YYCFCTPERL ESVRMAQQAA GKPTMYDRHC 150
    RNLGREEVEK RLATGEKAVV RLKVPDGTEI AFDDLARGRI AFESQTIDDS 200
    VLLKSDGFPT YHLAVVVDDH LMRVNQIIRG EEWIPSTPKH VLLYQYFGWP 250
    MPRIAHTPIL RDMSRRKLSK RSGDTSITGY RVQGYLPEGL RNFLTRIIWP 300
    HPEGKDVYDH EEFVRLFKAE DLPNTGPIVD PQLLDFINGQ YLRRLSSAEL 350
    YTATVEYLKF LLGLHQDIIF ETYHPSAPIK QTLTRAELGS FYSAFTANPT 400
    YTERVLTLEP ERYKRLSDIV VSTGFFFPAL FTPADPKLLA KPLGSPEKAG 450
    ALLGEYLRLY RPDAAQAEWE QSVRELAHEA GVKDGKLFMT LRVAVTGREQ 500
    TPPLFEVLTI LGGDEVQRRL ELAAAMPVSL 530
    Length:530
    Mass (Da):59,558
    Last modified:December 15, 2003 - v1
    Checksum:iB9F8B474FD8F7FF9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC90319.1.
    RefSeqiNP_925324.1. NC_005125.1.

    Genome annotation databases

    EnsemblBacteriaiBAC90319; BAC90319; BAC90319.
    GeneIDi2600779.
    KEGGigvi:gvip330.
    PATRICi22044233. VBIGloVio86258_2417.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC90319.1 .
    RefSeqi NP_925324.1. NC_005125.1.

    3D structure databases

    ProteinModelPortali Q7NI06.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 251221.gvip330.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC90319 ; BAC90319 ; BAC90319 .
    GeneIDi 2600779.
    KEGGi gvi:gvip330.
    PATRICi 22044233. VBIGloVio86258_2417.

    Phylogenomic databases

    eggNOGi COG0008.
    KOi K01885.
    OMAi AFEGPYF.
    OrthoDBi EOG6DRPF7.
    PhylomeDBi Q7NI06.

    Enzyme and pathway databases

    BioCyci GVIO251221:GH9A-2407-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_B. Glu_tRNA_synth_B.
    InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF48163. SSF48163. 2 hits.
    TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7421.

    Entry informationi

    Entry nameiSYE_GLOVI
    AccessioniPrimary (citable) accession number: Q7NI06
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3