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Q7NHX6

- PCP_GLOVI

UniProt

Q7NHX6 - PCP_GLOVI

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Protein

Pyrrolidone-carboxylate peptidase

Gene

pcp

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline.UniRule annotation

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei79 – 791UniRule annotation
Active sitei142 – 1421UniRule annotation
Active sitei165 – 1651UniRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. pyroglutamyl-peptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-2438-MONOMER.

Protein family/group databases

MEROPSiC15.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrrolidone-carboxylate peptidaseUniRule annotation (EC:3.4.19.3UniRule annotation)
Alternative name(s):
5-oxoprolyl-peptidaseUniRule annotation
Pyroglutamyl-peptidase IUniRule annotation
Short name:
PGP-IUniRule annotation
Short name:
PyraseUniRule annotation
Gene namesi
Name:pcpUniRule annotation
Ordered Locus Names:glr2409
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
ProteomesiUP000000557: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytosol Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Pyrrolidone-carboxylate peptidasePRO_0000184720Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi251221.glr2409.

Structurei

3D structure databases

ProteinModelPortaliQ7NHX6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C15 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2039.
HOGENOMiHOG000242641.
InParanoidiQ7NHX6.
KOiK01304.
OMAiKPNTPSM.
OrthoDBiEOG6X1124.

Family and domain databases

Gene3Di3.40.630.20. 1 hit.
HAMAPiMF_00417. Pyrrolid_peptidase.
InterProiIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029762. PGP-I_bact-type.
[Graphical view]
PANTHERiPTHR23402. PTHR23402. 1 hit.
PfamiPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSiPR00706. PYROGLUPTASE.
TIGRFAMsiTIGR00504. pyro_pdase. 1 hit.
PROSITEiPS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7NHX6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVLLTGFEP FAGELVNPSW EVASRLAERR ISGCTVAAER LPTVFGASIA
60 70 80 90 100
CLRTALERHR PQAVVCLGEA GGRAAISIER VALNLDEARI PDNKGQQPVE
110 120 130 140 150
IPVEPGAPAA YFATLPVRAI VAKLLAAGIP AEISRTAGGF VCNHTFYGLM
160 170 180 190 200
HHLGQATPVR AGFIHIPYLP EQAVRYPGKA SMELATTLRG IEMVLEVLRS

EQNVL
Length:205
Mass (Da):22,029
Last modified:December 15, 2003 - v1
Checksum:i75AF30338190842B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC90350.1.
RefSeqiNP_925355.1. NC_005125.1.
WP_011142404.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC90350; BAC90350; BAC90350.
GeneIDi2600810.
KEGGigvi:glr2409.
PATRICi22044295. VBIGloVio86258_2448.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC90350.1 .
RefSeqi NP_925355.1. NC_005125.1.
WP_011142404.1. NC_005125.1.

3D structure databases

ProteinModelPortali Q7NHX6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 251221.glr2409.

Protein family/group databases

MEROPSi C15.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC90350 ; BAC90350 ; BAC90350 .
GeneIDi 2600810.
KEGGi gvi:glr2409.
PATRICi 22044295. VBIGloVio86258_2448.

Phylogenomic databases

eggNOGi COG2039.
HOGENOMi HOG000242641.
InParanoidi Q7NHX6.
KOi K01304.
OMAi KPNTPSM.
OrthoDBi EOG6X1124.

Enzyme and pathway databases

BioCyci GVIO251221:GH9A-2438-MONOMER.

Family and domain databases

Gene3Di 3.40.630.20. 1 hit.
HAMAPi MF_00417. Pyrrolid_peptidase.
InterProi IPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029762. PGP-I_bact-type.
[Graphical view ]
PANTHERi PTHR23402. PTHR23402. 1 hit.
Pfami PF01470. Peptidase_C15. 1 hit.
[Graphical view ]
PIRSFi PIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSi PR00706. PYROGLUPTASE.
TIGRFAMsi TIGR00504. pyro_pdase. 1 hit.
PROSITEi PS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7421.

Entry informationi

Entry nameiPCP_GLOVI
AccessioniPrimary (citable) accession number: Q7NHX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: December 15, 2003
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3