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Q7NHW1

- MTAP_GLOVI

UniProt

Q7NHW1 - MTAP_GLOVI

Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

mtnP

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

    Catalytic activityi

    S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei14 – 141PhosphateUniRule annotation
    Sitei173 – 1731Important for substrate specificityUniRule annotation
    Binding sitei191 – 1911Substrate; via amide nitrogenUniRule annotation
    Binding sitei192 – 1921PhosphateUniRule annotation
    Sitei228 – 2281Important for substrate specificityUniRule annotation

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-methionine biosynthetic process from methylthioadenosine Source: UniProtKB-HAMAP
    2. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Enzyme and pathway databases

    BioCyciGVIO251221:GH9A-2453-MONOMER.
    UniPathwayiUPA00904; UER00873.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
    Alternative name(s):
    5'-methylthioadenosine phosphorylaseUniRule annotation
    Short name:
    MTA phosphorylaseUniRule annotation
    Short name:
    MTAPUniRule annotation
    Gene namesi
    Name:mtnPUniRule annotation
    Ordered Locus Names:gll2424
    OrganismiGloeobacter violaceus (strain PCC 7421)
    Taxonomic identifieri251221 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
    ProteomesiUP000000557: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299S-methyl-5'-thioadenosine phosphorylasePRO_0000415093Add
    BLAST

    Interactioni

    Subunit structurei

    Homohexamer. Dimer of a homotrimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi251221.gll2424.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7NHW1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni56 – 572Phosphate bindingUniRule annotation
    Regioni89 – 902Phosphate bindingUniRule annotation
    Regioni215 – 2173Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000228986.
    KOiK00772.
    OMAiCEAQLCY.
    OrthoDBiEOG6KHFXC.
    PhylomeDBiQ7NHW1.

    Family and domain databases

    Gene3Di3.40.50.1580. 1 hit.
    HAMAPiMF_01963. MTAP.
    InterProiIPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view]
    PANTHERiPTHR11904. PTHR11904. 1 hit.
    PfamiPF01048. PNP_UDP_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53167. SSF53167. 1 hit.
    TIGRFAMsiTIGR01694. MTAP. 1 hit.
    PROSITEiPS01240. PNP_MTAP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7NHW1-1 [UniParc]FASTAAdd to Basket

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    MSYPQARIGV IGGSGLYQMA DLADTVEVQF NTPFGPPSDA LVIGTLAGER    50
    VAFLPRHGRG HRLLPAELPF QANIYAMKML GVEYLLSASA VGSLREEYRP 100
    RDIVFPDQFF DRTKDRPSTF FGGGLVAHIG FDQPICTELA HLAAEAARGV 150
    ELIGETRIHT GGTYVCMEGP AFSTLAESRL YRSWGMDIIG MTNLQEAKLA 200
    REAEICYATM ALVTDYDCWH PDHGAVTVEL IIDNLHKNAE NAQRIVRAVV 250
    ERLHAAAPPC ASHSALKYAL LTQPEDVPQA TKQKLAAILA KYPAYRPEV 299
    Length:299
    Mass (Da):32,753
    Last modified:December 15, 2003 - v1
    Checksum:i0A134C2398AFD025
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC90365.1.
    RefSeqiNP_925370.1. NC_005125.1.
    WP_011142419.1. NC_005125.1.

    Genome annotation databases

    EnsemblBacteriaiBAC90365; BAC90365; BAC90365.
    GeneIDi2600825.
    KEGGigvi:gll2424.
    PATRICi22044321. VBIGloVio86258_2461.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC90365.1 .
    RefSeqi NP_925370.1. NC_005125.1.
    WP_011142419.1. NC_005125.1.

    3D structure databases

    ProteinModelPortali Q7NHW1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 251221.gll2424.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC90365 ; BAC90365 ; BAC90365 .
    GeneIDi 2600825.
    KEGGi gvi:gll2424.
    PATRICi 22044321. VBIGloVio86258_2461.

    Phylogenomic databases

    HOGENOMi HOG000228986.
    KOi K00772.
    OMAi CEAQLCY.
    OrthoDBi EOG6KHFXC.
    PhylomeDBi Q7NHW1.

    Enzyme and pathway databases

    UniPathwayi UPA00904 ; UER00873 .
    BioCyci GVIO251221:GH9A-2453-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1580. 1 hit.
    HAMAPi MF_01963. MTAP.
    InterProi IPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view ]
    PANTHERi PTHR11904. PTHR11904. 1 hit.
    Pfami PF01048. PNP_UDP_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53167. SSF53167. 1 hit.
    TIGRFAMsi TIGR01694. MTAP. 1 hit.
    PROSITEi PS01240. PNP_MTAP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7421.

    Entry informationi

    Entry nameiMTAP_GLOVI
    AccessioniPrimary (citable) accession number: Q7NHW1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 25, 2012
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3