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Q7NHW1

- MTAP_GLOVI

UniProt

Q7NHW1 - MTAP_GLOVI

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Protein
S-methyl-5'-thioadenosine phosphorylase
Gene
mtnP, gll2424
Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates By similarity.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141Phosphate By similarity
Sitei173 – 1731Important for substrate specificity By similarity
Binding sitei191 – 1911Substrate; via amide nitrogen By similarity
Binding sitei192 – 1921Phosphate By similarity
Sitei228 – 2281Important for substrate specificity By similarity

GO - Molecular functioni

  1. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP
  2. phosphorylase activity Source: InterPro

GO - Biological processi

  1. L-methionine salvage from methylthioadenosine Source: UniProtKB-HAMAP
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-2453-MONOMER.
UniPathwayiUPA00904; UER00873.

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylase (EC:2.4.2.28)
Alternative name(s):
5'-methylthioadenosine phosphorylase
Short name:
MTA phosphorylase
Short name:
MTAP
Gene namesi
Name:mtnP
Ordered Locus Names:gll2424
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
ProteomesiUP000000557: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299S-methyl-5'-thioadenosine phosphorylaseUniRule annotation
PRO_0000415093Add
BLAST

Interactioni

Subunit structurei

Homohexamer. Dimer of a homotrimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi251221.gll2424.

Structurei

3D structure databases

ProteinModelPortaliQ7NHW1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni56 – 572Phosphate binding By similarity
Regioni89 – 902Phosphate binding By similarity
Regioni215 – 2173Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000228986.
KOiK00772.
OMAiCEAQLCY.
OrthoDBiEOG6KHFXC.
PhylomeDBiQ7NHW1.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01963. MTAP.
InterProiIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01694. MTAP. 1 hit.
PROSITEiPS01240. PNP_MTAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7NHW1-1 [UniParc]FASTAAdd to Basket

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MSYPQARIGV IGGSGLYQMA DLADTVEVQF NTPFGPPSDA LVIGTLAGER    50
VAFLPRHGRG HRLLPAELPF QANIYAMKML GVEYLLSASA VGSLREEYRP 100
RDIVFPDQFF DRTKDRPSTF FGGGLVAHIG FDQPICTELA HLAAEAARGV 150
ELIGETRIHT GGTYVCMEGP AFSTLAESRL YRSWGMDIIG MTNLQEAKLA 200
REAEICYATM ALVTDYDCWH PDHGAVTVEL IIDNLHKNAE NAQRIVRAVV 250
ERLHAAAPPC ASHSALKYAL LTQPEDVPQA TKQKLAAILA KYPAYRPEV 299
Length:299
Mass (Da):32,753
Last modified:December 15, 2003 - v1
Checksum:i0A134C2398AFD025
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC90365.1.
RefSeqiNP_925370.1. NC_005125.1.
WP_011142419.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC90365; BAC90365; BAC90365.
GeneIDi2600825.
KEGGigvi:gll2424.
PATRICi22044321. VBIGloVio86258_2461.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC90365.1 .
RefSeqi NP_925370.1. NC_005125.1.
WP_011142419.1. NC_005125.1.

3D structure databases

ProteinModelPortali Q7NHW1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 251221.gll2424.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC90365 ; BAC90365 ; BAC90365 .
GeneIDi 2600825.
KEGGi gvi:gll2424.
PATRICi 22044321. VBIGloVio86258_2461.

Phylogenomic databases

HOGENOMi HOG000228986.
KOi K00772.
OMAi CEAQLCY.
OrthoDBi EOG6KHFXC.
PhylomeDBi Q7NHW1.

Enzyme and pathway databases

UniPathwayi UPA00904 ; UER00873 .
BioCyci GVIO251221:GH9A-2453-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
HAMAPi MF_01963. MTAP.
InterProi IPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01694. MTAP. 1 hit.
PROSITEi PS01240. PNP_MTAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7421.

Entry informationi

Entry nameiMTAP_GLOVI
AccessioniPrimary (citable) accession number: Q7NHW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: December 15, 2003
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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