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Q7NHW1

- MTAP_GLOVI

UniProt

Q7NHW1 - MTAP_GLOVI

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Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

mtnP

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141PhosphateUniRule annotation
Sitei173 – 1731Important for substrate specificityUniRule annotation
Binding sitei191 – 1911Substrate; via amide nitrogenUniRule annotation
Binding sitei192 – 1921PhosphateUniRule annotation
Sitei228 – 2281Important for substrate specificityUniRule annotation

GO - Molecular functioni

  1. phosphorylase activity Source: InterPro
  2. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-methionine biosynthetic process from methylthioadenosine Source: UniProtKB-HAMAP
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-2453-MONOMER.
UniPathwayiUPA00904; UER00873.

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
Alternative name(s):
5'-methylthioadenosine phosphorylaseUniRule annotation
Short name:
MTA phosphorylaseUniRule annotation
Short name:
MTAPUniRule annotation
Gene namesi
Name:mtnPUniRule annotation
Ordered Locus Names:gll2424
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
ProteomesiUP000000557: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299S-methyl-5'-thioadenosine phosphorylasePRO_0000415093Add
BLAST

Interactioni

Subunit structurei

Homohexamer. Dimer of a homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi251221.gll2424.

Structurei

3D structure databases

ProteinModelPortaliQ7NHW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni56 – 572Phosphate bindingUniRule annotation
Regioni89 – 902Phosphate bindingUniRule annotation
Regioni215 – 2173Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000228986.
InParanoidiQ7NHW1.
KOiK00772.
OMAiCEAQLCY.
OrthoDBiEOG6KHFXC.
PhylomeDBiQ7NHW1.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01963. MTAP.
InterProiIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01694. MTAP. 1 hit.
PROSITEiPS01240. PNP_MTAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7NHW1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSYPQARIGV IGGSGLYQMA DLADTVEVQF NTPFGPPSDA LVIGTLAGER
60 70 80 90 100
VAFLPRHGRG HRLLPAELPF QANIYAMKML GVEYLLSASA VGSLREEYRP
110 120 130 140 150
RDIVFPDQFF DRTKDRPSTF FGGGLVAHIG FDQPICTELA HLAAEAARGV
160 170 180 190 200
ELIGETRIHT GGTYVCMEGP AFSTLAESRL YRSWGMDIIG MTNLQEAKLA
210 220 230 240 250
REAEICYATM ALVTDYDCWH PDHGAVTVEL IIDNLHKNAE NAQRIVRAVV
260 270 280 290
ERLHAAAPPC ASHSALKYAL LTQPEDVPQA TKQKLAAILA KYPAYRPEV
Length:299
Mass (Da):32,753
Last modified:December 15, 2003 - v1
Checksum:i0A134C2398AFD025
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA. Translation: BAC90365.1.
RefSeqiNP_925370.1. NC_005125.1.
WP_011142419.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC90365; BAC90365; BAC90365.
GeneIDi2600825.
KEGGigvi:gll2424.
PATRICi22044321. VBIGloVio86258_2461.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA. Translation: BAC90365.1 .
RefSeqi NP_925370.1. NC_005125.1.
WP_011142419.1. NC_005125.1.

3D structure databases

ProteinModelPortali Q7NHW1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 251221.gll2424.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC90365 ; BAC90365 ; BAC90365 .
GeneIDi 2600825.
KEGGi gvi:gll2424.
PATRICi 22044321. VBIGloVio86258_2461.

Phylogenomic databases

HOGENOMi HOG000228986.
InParanoidi Q7NHW1.
KOi K00772.
OMAi CEAQLCY.
OrthoDBi EOG6KHFXC.
PhylomeDBi Q7NHW1.

Enzyme and pathway databases

UniPathwayi UPA00904 ; UER00873 .
BioCyci GVIO251221:GH9A-2453-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
HAMAPi MF_01963. MTAP.
InterProi IPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01694. MTAP. 1 hit.
PROSITEi PS01240. PNP_MTAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7421.

Entry informationi

Entry nameiMTAP_GLOVI
AccessioniPrimary (citable) accession number: Q7NHW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: December 15, 2003
Last modified: November 26, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3