Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q7NHJ3

- MDH_GLOVI

UniProt

Q7NHJ3 - MDH_GLOVI

Protein

Malate dehydrogenase

Gene

mdh

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391NADUniRule annotation
    Binding sitei88 – 881SubstrateUniRule annotation
    Binding sitei94 – 941SubstrateUniRule annotation
    Binding sitei101 – 1011NADUniRule annotation
    Binding sitei126 – 1261SubstrateUniRule annotation
    Binding sitei157 – 1571SubstrateUniRule annotation
    Active sitei181 – 1811Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 206NADUniRule annotation
    Nucleotide bindingi124 – 1263NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciGVIO251221:GH9A-2574-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:gll2542
    OrganismiGloeobacter violaceus (strain PCC 7421)
    Taxonomic identifieri251221 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
    ProteomesiUP000000557: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 325325Malate dehydrogenasePRO_0000113454Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi251221.gll2542.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7NHJ3.
    SMRiQ7NHJ3. Positions 9-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiLDLMEAQ.
    OrthoDBiEOG6091FG.
    PhylomeDBiQ7NHJ3.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7NHJ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAARSCRESK VSILGAGNVG SALAQRLIQG NVADVVLLDI VEGRPQGITL    50
    DLLEACGVEG HTCRITGTND YAQTAGSDVL VVAAGFARQP GMSRDDLLLT 100
    NTRIVFEVTQ KAVAHSPEAT VVVVTNPLDA MSHVAWRASG LVPERVMGMA 150
    GVLDAARFET FIAWELGFSV RDIRAMVLGG HGDLMVPLPR YTTISGVPLT 200
    QLLSSARIDA LIERTRTGGA EIVHLLKRGG AYYAPAAAAA RMIETLLGDE 250
    RRLLPVAAYL SGEYGLRNIH MGVPVILSRH GVERVVELTL ETEEKAALYR 300
    SAHTIRASLD QIAHLMPANQ PPSAV 325
    Length:325
    Mass (Da):34,685
    Last modified:December 15, 2003 - v1
    Checksum:iD7F5F1DB4253BFEC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC90483.1.
    RefSeqiNP_925488.1. NC_005125.1.

    Genome annotation databases

    EnsemblBacteriaiBAC90483; BAC90483; BAC90483.
    GeneIDi2600943.
    KEGGigvi:gll2542.
    PATRICi22044565. VBIGloVio86258_2580.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC90483.1 .
    RefSeqi NP_925488.1. NC_005125.1.

    3D structure databases

    ProteinModelPortali Q7NHJ3.
    SMRi Q7NHJ3. Positions 9-312.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 251221.gll2542.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC90483 ; BAC90483 ; BAC90483 .
    GeneIDi 2600943.
    KEGGi gvi:gll2542.
    PATRICi 22044565. VBIGloVio86258_2580.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi LDLMEAQ.
    OrthoDBi EOG6091FG.
    PhylomeDBi Q7NHJ3.

    Enzyme and pathway databases

    BioCyci GVIO251221:GH9A-2574-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7421.

    Entry informationi

    Entry nameiMDH_GLOVI
    AccessioniPrimary (citable) accession number: Q7NHJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3