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Protein

Malate dehydrogenase

Gene

mdh

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39NADUniRule annotation1
Binding sitei88SubstrateUniRule annotation1
Binding sitei94SubstrateUniRule annotation1
Binding sitei101NADUniRule annotation1
Binding sitei126SubstrateUniRule annotation1
Binding sitei157SubstrateUniRule annotation1
Active sitei181Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 20NADUniRule annotation6
Nucleotide bindingi124 – 126NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:gll2542
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacteraceaeGloeobacter
Proteomesi
  • UP000000557 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001134541 – 325Malate dehydrogenaseAdd BLAST325

Interactioni

Protein-protein interaction databases

STRINGi251221.gll2542.

Structurei

3D structure databases

ProteinModelPortaliQ7NHJ3.
SMRiQ7NHJ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000213794.
InParanoidiQ7NHJ3.
KOiK00024.
OMAiRQPGQTR.
OrthoDBiPOG091H02N6.
PhylomeDBiQ7NHJ3.

Family and domain databases

CDDicd01339. LDH-like_MDH. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
PANTHERiPTHR11540:SF31. PTHR11540:SF31. 1 hit.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7NHJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARSCRESK VSILGAGNVG SALAQRLIQG NVADVVLLDI VEGRPQGITL
60 70 80 90 100
DLLEACGVEG HTCRITGTND YAQTAGSDVL VVAAGFARQP GMSRDDLLLT
110 120 130 140 150
NTRIVFEVTQ KAVAHSPEAT VVVVTNPLDA MSHVAWRASG LVPERVMGMA
160 170 180 190 200
GVLDAARFET FIAWELGFSV RDIRAMVLGG HGDLMVPLPR YTTISGVPLT
210 220 230 240 250
QLLSSARIDA LIERTRTGGA EIVHLLKRGG AYYAPAAAAA RMIETLLGDE
260 270 280 290 300
RRLLPVAAYL SGEYGLRNIH MGVPVILSRH GVERVVELTL ETEEKAALYR
310 320
SAHTIRASLD QIAHLMPANQ PPSAV
Length:325
Mass (Da):34,685
Last modified:December 15, 2003 - v1
Checksum:iD7F5F1DB4253BFEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA. Translation: BAC90483.1.
RefSeqiNP_925488.1. NC_005125.1.
WP_011142537.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC90483; BAC90483; BAC90483.
GeneIDi2600943.
KEGGigvi:gll2542.
PATRICifig|251221.4.peg.2580.

Similar proteinsi

Entry informationi

Entry nameiMDH_GLOVI
AccessioniPrimary (citable) accession number: Q7NHJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: December 15, 2003
Last modified: August 30, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families