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Protein

Malate dehydrogenase

Gene

mdh

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391NADUniRule annotation
Binding sitei88 – 881SubstrateUniRule annotation
Binding sitei94 – 941SubstrateUniRule annotation
Binding sitei101 – 1011NADUniRule annotation
Binding sitei126 – 1261SubstrateUniRule annotation
Binding sitei157 – 1571SubstrateUniRule annotation
Active sitei181 – 1811Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 206NADUniRule annotation
Nucleotide bindingi124 – 1263NADUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-2574-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:gll2542
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
ProteomesiUP000000557 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Malate dehydrogenasePRO_0000113454Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi251221.gll2542.

Structurei

3D structure databases

ProteinModelPortaliQ7NHJ3.
SMRiQ7NHJ3. Positions 9-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
InParanoidiQ7NHJ3.
KOiK00024.
OMAiFVGVPVI.
OrthoDBiEOG6091FG.
PhylomeDBiQ7NHJ3.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7NHJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARSCRESK VSILGAGNVG SALAQRLIQG NVADVVLLDI VEGRPQGITL
60 70 80 90 100
DLLEACGVEG HTCRITGTND YAQTAGSDVL VVAAGFARQP GMSRDDLLLT
110 120 130 140 150
NTRIVFEVTQ KAVAHSPEAT VVVVTNPLDA MSHVAWRASG LVPERVMGMA
160 170 180 190 200
GVLDAARFET FIAWELGFSV RDIRAMVLGG HGDLMVPLPR YTTISGVPLT
210 220 230 240 250
QLLSSARIDA LIERTRTGGA EIVHLLKRGG AYYAPAAAAA RMIETLLGDE
260 270 280 290 300
RRLLPVAAYL SGEYGLRNIH MGVPVILSRH GVERVVELTL ETEEKAALYR
310 320
SAHTIRASLD QIAHLMPANQ PPSAV
Length:325
Mass (Da):34,685
Last modified:December 15, 2003 - v1
Checksum:iD7F5F1DB4253BFEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA. Translation: BAC90483.1.
RefSeqiNP_925488.1. NC_005125.1.
WP_011142537.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC90483; BAC90483; BAC90483.
GeneIDi2600943.
KEGGigvi:gll2542.
PATRICi22044565. VBIGloVio86258_2580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA. Translation: BAC90483.1.
RefSeqiNP_925488.1. NC_005125.1.
WP_011142537.1. NC_005125.1.

3D structure databases

ProteinModelPortaliQ7NHJ3.
SMRiQ7NHJ3. Positions 9-312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi251221.gll2542.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC90483; BAC90483; BAC90483.
GeneIDi2600943.
KEGGigvi:gll2542.
PATRICi22044565. VBIGloVio86258_2580.

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
InParanoidiQ7NHJ3.
KOiK00024.
OMAiFVGVPVI.
OrthoDBiEOG6091FG.
PhylomeDBiQ7NHJ3.

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-2574-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7421.

Entry informationi

Entry nameiMDH_GLOVI
AccessioniPrimary (citable) accession number: Q7NHJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: December 15, 2003
Last modified: July 22, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.