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Q7NHJ3

- MDH_GLOVI

UniProt

Q7NHJ3 - MDH_GLOVI

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Protein
Malate dehydrogenase
Gene
mdh, gll2542
Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391NAD By similarity
Binding sitei88 – 881Substrate By similarity
Binding sitei94 – 941Substrate By similarity
Binding sitei101 – 1011NAD By similarity
Binding sitei126 – 1261Substrate By similarity
Binding sitei157 – 1571Substrate By similarity
Active sitei181 – 1811Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 206NAD By similarity
Nucleotide bindingi124 – 1263NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-2574-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:gll2542
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
ProteomesiUP000000557: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Malate dehydrogenaseUniRule annotation
PRO_0000113454Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi251221.gll2542.

Structurei

3D structure databases

ProteinModelPortaliQ7NHJ3.
SMRiQ7NHJ3. Positions 9-312.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiLDLMEAQ.
OrthoDBiEOG6091FG.
PhylomeDBiQ7NHJ3.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7NHJ3-1 [UniParc]FASTAAdd to Basket

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MAARSCRESK VSILGAGNVG SALAQRLIQG NVADVVLLDI VEGRPQGITL    50
DLLEACGVEG HTCRITGTND YAQTAGSDVL VVAAGFARQP GMSRDDLLLT 100
NTRIVFEVTQ KAVAHSPEAT VVVVTNPLDA MSHVAWRASG LVPERVMGMA 150
GVLDAARFET FIAWELGFSV RDIRAMVLGG HGDLMVPLPR YTTISGVPLT 200
QLLSSARIDA LIERTRTGGA EIVHLLKRGG AYYAPAAAAA RMIETLLGDE 250
RRLLPVAAYL SGEYGLRNIH MGVPVILSRH GVERVVELTL ETEEKAALYR 300
SAHTIRASLD QIAHLMPANQ PPSAV 325
Length:325
Mass (Da):34,685
Last modified:December 15, 2003 - v1
Checksum:iD7F5F1DB4253BFEC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC90483.1.
RefSeqiNP_925488.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC90483; BAC90483; BAC90483.
GeneIDi2600943.
KEGGigvi:gll2542.
PATRICi22044565. VBIGloVio86258_2580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC90483.1 .
RefSeqi NP_925488.1. NC_005125.1.

3D structure databases

ProteinModelPortali Q7NHJ3.
SMRi Q7NHJ3. Positions 9-312.
ModBasei Search...

Protein-protein interaction databases

STRINGi 251221.gll2542.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC90483 ; BAC90483 ; BAC90483 .
GeneIDi 2600943.
KEGGi gvi:gll2542.
PATRICi 22044565. VBIGloVio86258_2580.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi LDLMEAQ.
OrthoDBi EOG6091FG.
PhylomeDBi Q7NHJ3.

Enzyme and pathway databases

BioCyci GVIO251221:GH9A-2574-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7421.

Entry informationi

Entry nameiMDH_GLOVI
AccessioniPrimary (citable) accession number: Q7NHJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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