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Protein

Catalase-peroxidase

Gene

katG

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei94 – 941Transition state stabilizerUniRule annotation
Active sitei98 – 981Proton acceptorUniRule annotation
Metal bindingi261 – 2611Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-2806-MONOMER.

Protein family/group databases

PeroxiBasei2378. GviCP01_PCC7421.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:gll2771
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
Proteomesi
  • UP000000557 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Catalase-peroxidasePRO_0000354803Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki97 ↔ 220Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-246)UniRule annotation
Cross-linki220 ↔ 246Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-97)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi251221.gll2771.

Structurei

3D structure databases

ProteinModelPortaliQ7NGW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
InParanoidiQ7NGW6.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.
PhylomeDBiQ7NGW6.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7NGW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVEAKCPMG GGKVEGRAVL FEMTNRLWWP NHLDLSVLHQ NPPAGNPMGE
60 70 80 90 100
GFNYAAEFES LDLAAVKQDI FALMTESQDW WPADYGHYGP LFIRMAWHAA
110 120 130 140 150
GTYRIGDGRG GAGAGTQRFA PLNSWPDNAN LDKARLLLWP IKEKYGRKLS
160 170 180 190 200
WGDLLILAGN CALESMGFKT AGFAGGRVDI WEPENDIFWG PEREWLGDER
210 220 230 240 250
YSSDRDLAHP LAAVQMGLIY VNPEGPNGKP DPMAAAHDIR ETFGRMAMND
260 270 280 290 300
EETVALIAGG HTFGKCHGAA EPSQYVGAEP EGAGIERQGL GWDNSFGSGR
310 320 330 340 350
GVHTITSGLE GAWTKNPIQW DNGYFENLFE YEWELTKSPA GAHQWTPKNP
360 370 380 390 400
EAASTVPDAH DPHKRHAPMM ATTDLAMRAD PAYEKISRRF YDNPDQLAHA
410 420 430 440 450
FAEAWYKLTH RDMGPYARLL GPEVPSEPRI WQDPVPASDH PLIDDADIAE
460 470 480 490 500
LKAQILAAGL SIARLVTTAW ASASTFRGTD KRGGANGARI RLVPQKDWAV
510 520 530 540 550
NEPTELATAL AKLEAIQQDF NAGQTGGKQV SLADLIVLGG CAAVEQAAKK
560 570 580 590 600
AGHDITVPFT PGRTDASPDQ TDVESFAPLE PKIDGFRNYV GEKSVYSAEE
610 620 630 640 650
MLVDRAHLLT LSAPEMTVLV GGLRVLGANY GGSKLGVFTE RPETLTNDFF
660 670 680 690 700
VNLLKTSTSM KWEASPDADV FEASDRATGE KKWAGTRVDL IFGSNSQLRA
710 720 730
LSEAYATADA QQTFVDAFVA AWTKVMNLDR FDLPR
Length:735
Mass (Da):80,389
Last modified:December 15, 2003 - v1
Checksum:i18F3B16163E81E7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA. Translation: BAC90712.1.
RefSeqiNP_925717.1. NC_005125.1.
WP_011142765.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC90712; BAC90712; BAC90712.
GeneIDi2601172.
KEGGigvi:gll2771.
PATRICi22045009. VBIGloVio86258_2799.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA. Translation: BAC90712.1.
RefSeqiNP_925717.1. NC_005125.1.
WP_011142765.1. NC_005125.1.

3D structure databases

ProteinModelPortaliQ7NGW6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi251221.gll2771.

Protein family/group databases

PeroxiBasei2378. GviCP01_PCC7421.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC90712; BAC90712; BAC90712.
GeneIDi2601172.
KEGGigvi:gll2771.
PATRICi22045009. VBIGloVio86258_2799.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
InParanoidiQ7NGW6.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.
PhylomeDBiQ7NGW6.

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-2806-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7421.

Entry informationi

Entry nameiKATG_GLOVI
AccessioniPrimary (citable) accession number: Q7NGW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: December 15, 2003
Last modified: July 6, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.