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Q7NGR7

- OTC_GLOVI

UniProt

Q7NGR7 - OTC_GLOVI

Protein

Ornithine carbamoyltransferase

Gene

argF

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

    Catalytic activityi

    Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei15 – 151Carbamoyl phosphateBy similarity
    Sitei36 – 361Important for structural integrityBy similarity
    Binding sitei73 – 731Carbamoyl phosphateBy similarity
    Binding sitei84 – 841Carbamoyl phosphateBy similarity
    Binding sitei108 – 1081Carbamoyl phosphateBy similarity
    Sitei148 – 1481Important for structural integrityBy similarity
    Binding sitei166 – 1661OrnithineBy similarity
    Binding sitei230 – 2301OrnithineBy similarity
    Binding sitei280 – 2801Carbamoyl phosphateBy similarity
    Binding sitei298 – 2981Carbamoyl phosphateBy similarity

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. ornithine carbamoyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Enzyme and pathway databases

    BioCyciGVIO251221:GH9A-3139-MONOMER.
    UniPathwayiUPA00068; UER00112.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ornithine carbamoyltransferase (EC:2.1.3.3)
    Short name:
    OTCase
    Gene namesi
    Name:argF
    Ordered Locus Names:gll3101
    OrganismiGloeobacter violaceus (strain PCC 7421)
    Taxonomic identifieri251221 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
    ProteomesiUP000000557: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313Ornithine carbamoyltransferasePRO_0000112927Add
    BLAST

    Proteomic databases

    PRIDEiQ7NGR7.

    Interactioni

    Subunit structurei

    Homohexamer.1 Publication

    Protein-protein interaction databases

    STRINGi251221.gvip429.

    Structurei

    Secondary structure

    1
    313
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi14 – 163
    Helixi17 – 193
    Helixi22 – 3615
    Beta strandi48 – 558
    Helixi58 – 7013
    Beta strandi74 – 785
    Helixi91 – 988
    Turni99 – 1013
    Beta strandi103 – 1086
    Helixi112 – 12211
    Beta strandi126 – 1305
    Helixi136 – 15015
    Beta strandi157 – 1626
    Helixi166 – 17712
    Beta strandi181 – 1855
    Helixi194 – 20714
    Beta strandi211 – 2155
    Helixi217 – 2215
    Beta strandi225 – 2295
    Helixi245 – 2484
    Helixi255 – 2595
    Beta strandi266 – 2694
    Turni276 – 2783
    Helixi281 – 2855
    Helixi291 – 31020

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3GD5X-ray2.10A/B/C/D/E/F2-313[»]
    ProteinModelPortaliQ7NGR7.
    SMRiQ7NGR7. Positions 12-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ7NGR7.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni57 – 615Carbamoyl phosphate bindingBy similarity
    Regioni135 – 1384Carbamoyl phosphate bindingBy similarity
    Regioni234 – 2352Ornithine bindingBy similarity
    Regioni269 – 2724Carbamoyl phosphate bindingBy similarity

    Sequence similaritiesi

    Belongs to the ATCase/OTCase family.Curated

    Phylogenomic databases

    eggNOGiCOG0078.
    KOiK00611.
    OMAiKWAEQNA.
    OrthoDBiEOG690MGV.
    PhylomeDBiQ7NGR7.

    Family and domain databases

    Gene3Di3.40.50.1370. 2 hits.
    HAMAPiMF_01109. OTCase.
    InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
    IPR006130. Asp/Orn_carbamoylTrfase.
    IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
    IPR002292. Orn/put_carbamltrans.
    IPR024904. Orn_carbamltrans.
    [Graphical view]
    PfamiPF00185. OTCace. 1 hit.
    PF02729. OTCace_N. 1 hit.
    [Graphical view]
    PRINTSiPR00100. AOTCASE.
    PR00102. OTCASE.
    SUPFAMiSSF53671. SSF53671. 1 hit.
    TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
    PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7NGR7-1 [UniParc]FASTAAdd to Basket

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    MSASLGATRF RPDLLSLDDL DEAQLHALLT LAHQLKRGER VANLHGKVLG    50
    LVFLKASTRT RVSFTVAMYQ LGGQVIDLSP SNTQVGRGEP VRDTARVLGR 100
    YVDGLAIRTF AQTELEEYAH YAGIPVINAL TDHEHPCQVV ADLLTIRENF 150
    GRLAGLKLAY VGDGNNVAHS LLLGCAKVGM SIAVATPEGF TPDPAVSARA 200
    SEIAGRTGAE VQILRDPFEA ARGAHILYTD VWTSMGQEAE TQHRLQLFEQ 250
    YQINAALLNC AAAEAIVLHC LPAHRGEEIT DEVMEGPRSR IWDEAENRLH 300
    AQKAVLAALM GGR 313
    Length:313
    Mass (Da):33,958
    Last modified:December 15, 2003 - v1
    Checksum:i705948D76BE67854
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC91042.1.
    RefSeqiNP_926047.1. NC_005125.1.
    WP_011143094.1. NC_005125.1.

    Genome annotation databases

    EnsemblBacteriaiBAC91042; BAC91042; BAC91042.
    GeneIDi2601502.
    KEGGigvi:gvip429.
    PATRICi22045673. VBIGloVio86258_3130.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC91042.1 .
    RefSeqi NP_926047.1. NC_005125.1.
    WP_011143094.1. NC_005125.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3GD5 X-ray 2.10 A/B/C/D/E/F 2-313 [» ]
    ProteinModelPortali Q7NGR7.
    SMRi Q7NGR7. Positions 12-312.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 251221.gvip429.

    Proteomic databases

    PRIDEi Q7NGR7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC91042 ; BAC91042 ; BAC91042 .
    GeneIDi 2601502.
    KEGGi gvi:gvip429.
    PATRICi 22045673. VBIGloVio86258_3130.

    Phylogenomic databases

    eggNOGi COG0078.
    KOi K00611.
    OMAi KWAEQNA.
    OrthoDBi EOG690MGV.
    PhylomeDBi Q7NGR7.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00112 .
    BioCyci GVIO251221:GH9A-3139-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q7NGR7.

    Family and domain databases

    Gene3Di 3.40.50.1370. 2 hits.
    HAMAPi MF_01109. OTCase.
    InterProi IPR006132. Asp/Orn_carbamoyltranf_P-bd.
    IPR006130. Asp/Orn_carbamoylTrfase.
    IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
    IPR002292. Orn/put_carbamltrans.
    IPR024904. Orn_carbamltrans.
    [Graphical view ]
    Pfami PF00185. OTCace. 1 hit.
    PF02729. OTCace_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00100. AOTCASE.
    PR00102. OTCASE.
    SUPFAMi SSF53671. SSF53671. 1 hit.
    TIGRFAMsi TIGR00658. orni_carb_tr. 1 hit.
    PROSITEi PS00097. CARBAMOYLTRANSFERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7421.
    2. "Crystal structure of ornithine carbamoyltransferase from Gloeobacter violaceus."
      New york sgx research center for structural genomics (NYSGXRC)
      Fedorov A.A., Fedorov E.V., Toro R., Ramagopal U.A., Sauder J.M., Burley S.K., Almo S.C.
      Submitted (FEB-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS), SUBUNIT.

    Entry informationi

    Entry nameiOTC_GLOVI
    AccessioniPrimary (citable) accession number: Q7NGR7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3