Q7NGR7 (OTC_GLOVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase
Short name=OTCase
EC=2.1.3.3

Gene names

Name:	argF
Ordered Locus Names:	gll3101

Organism

Gloeobacter violaceus (strain PCC 7421)

Taxonomic identifier

251221 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Gloeobacteria › Gloeobacterales › Gloeobacter

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 313

313

Ornithine carbamoyltransferase HAMAP MF_01109

PRO_0000112927

Regions

Region

57 – 61

5

Carbamoyl phosphate binding By similarity

Region

269 – 272

4

Ornithine binding By similarity

Sites

Binding site

108

1

Carbamoyl phosphate By similarity

Binding site

135

1

Carbamoyl phosphate By similarity

Site

36

1

Important for structural integrity By similarity

Site

148

1

Important for structural integrity By similarity

Secondary structure

1

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313

Helix Strand Turn

Details...

Beta strand

14 – 16

3

Helix

17 – 19

3

Helix

22 – 36

15

Beta strand

51 – 55

5

Helix

58 – 70

13

Beta strand

75 – 78

4

Helix

91 – 97

7

Beta strand

106 – 108

3

Helix

112 – 121

10

Beta strand

127 – 130

4

Helix

136 – 149

14

Beta strand

157 – 161

5

Helix

166 – 172

7

Beta strand

181 – 185

5

Helix

194 – 203

10

Beta strand

211 – 215

5

Helix

217 – 221

5

Beta strand

226 – 229

4

Helix

245 – 248

4

Helix

255 – 259

5

Beta strand

266 – 269

4

Helix

281 – 284

4

Helix

291 – 309

19

Sequences

	Sequence		Length	Mass (Da)
	Q7NGR7 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 705948D76BE67854	FASTA	313	33,958
	10 20 30 40 50 60 MSASLGATRF RPDLLSLDDL DEAQLHALLT LAHQLKRGER VANLHGKVLG LVFLKASTRT 70 80 90 100 110 120 RVSFTVAMYQ LGGQVIDLSP SNTQVGRGEP VRDTARVLGR YVDGLAIRTF AQTELEEYAH 130 140 150 160 170 180 YAGIPVINAL TDHEHPCQVV ADLLTIRENF GRLAGLKLAY VGDGNNVAHS LLLGCAKVGM 190 200 210 220 230 240 SIAVATPEGF TPDPAVSARA SEIAGRTGAE VQILRDPFEA ARGAHILYTD VWTSMGQEAE 250 260 270 280 290 300 TQHRLQLFEQ YQINAALLNC AAAEAIVLHC LPAHRGEEIT DEVMEGPRSR IWDEAENRLH 310 AQKAVLAALM GGR

References

[1]

"Complete genome structure of Gloeobacter violaceus PCC 7421, a cyanobacterium that lacks thylakoids." Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T., Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M., Tabata S. DNA Res. 10:137-145(2003) [PubMed: 14621292] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7421.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BA000045 Genomic DNA. Translation: BAC91042.1.

RefSeq

NP_926047.1. NC_005125.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3GD5	X-ray	2.10	A/B/C/D/E/F	2-313	[»]

ProteinModelPortal

Q7NGR7.

SMR

Q7NGR7. Positions 12-312.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

2601502.

GenomeReviews

Gene locus gll3101 in contig BA000045_GR.

NMPDR

fig|251221.1.peg.3101.

PATRIC

22045673. VBIGloVio86258_3130.

Phylogenomic databases

HOGENOM

HBG579429.

OMA

KHLLSIK.

PhylomeDB

Q7NGR7.

ProtClustDB

PRK00779.

Enzyme and pathway databases

BioCyc

GVIO251221:GLL3101-MONOMER.

Family and domain databases

HAMAP

MF_01109. OTCase.
[Tree]

InterPro

IPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view]

Pfam

PF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]

PRINTS

PR00100. AOTCASE.
PR00102. OTCASE.

SUPFAM

SSF53671. Asp/Orn_carbamoyltranf. 1 hit.

TIGRFAMs

TIGR00658. Orni_carb_tr. 1 hit.

PROSITE

PS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

OTC_GLOVI

Accession

Primary (citable) accession number: Q7NGR7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program