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Protein

Ornithine carbamoyltransferase

Gene

argF

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.UniRule annotation

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei84Carbamoyl phosphateBy similarity1
Binding sitei108Carbamoyl phosphateBy similarity1
Binding sitei166OrnithineBy similarity1
Binding sitei230OrnithineBy similarity1
Binding sitei298Carbamoyl phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciGVIO251221:G1G3K-3138-MONOMER
UniPathwayiUPA00068; UER00112

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferaseUniRule annotation (EC:2.1.3.3UniRule annotation)
Short name:
OTCaseUniRule annotation
Gene namesi
Name:argFUniRule annotation
Ordered Locus Names:gll3101
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacteraceaeGloeobacter
Proteomesi
  • UP000000557 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001129271 – 313Ornithine carbamoyltransferaseAdd BLAST313

Proteomic databases

PRIDEiQ7NGR7

Interactioni

Subunit structurei

Homohexamer.1 Publication

Protein-protein interaction databases

STRINGi251221.gvip429

Structurei

Secondary structure

1313
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi14 – 16Combined sources3
Helixi17 – 19Combined sources3
Helixi22 – 36Combined sources15
Beta strandi48 – 55Combined sources8
Helixi58 – 70Combined sources13
Beta strandi74 – 78Combined sources5
Helixi91 – 98Combined sources8
Turni99 – 101Combined sources3
Beta strandi103 – 108Combined sources6
Helixi112 – 122Combined sources11
Beta strandi126 – 130Combined sources5
Helixi136 – 150Combined sources15
Beta strandi157 – 162Combined sources6
Helixi166 – 177Combined sources12
Beta strandi181 – 185Combined sources5
Helixi194 – 207Combined sources14
Beta strandi211 – 215Combined sources5
Helixi217 – 221Combined sources5
Beta strandi225 – 229Combined sources5
Helixi245 – 248Combined sources4
Helixi255 – 259Combined sources5
Beta strandi266 – 269Combined sources4
Turni276 – 278Combined sources3
Helixi281 – 285Combined sources5
Helixi291 – 310Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GD5X-ray2.10A/B/C/D/E/F2-313[»]
ProteinModelPortaliQ7NGR7
SMRiQ7NGR7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7NGR7

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni57 – 60Carbamoyl phosphate bindingBy similarity4
Regioni135 – 138Carbamoyl phosphate bindingBy similarity4
Regioni234 – 235Ornithine bindingBy similarity2
Regioni270 – 271Carbamoyl phosphate bindingBy similarity2

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DBV Bacteria
COG0078 LUCA
InParanoidiQ7NGR7
KOiK00611
OMAiDGNNVCN
OrthoDBiPOG091H0543
PhylomeDBiQ7NGR7

Family and domain databases

Gene3Di3.40.50.1370, 3 hits
HAMAPiMF_01109 OTCase, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
IPR002292 Orn/put_carbamltrans
IPR024904 OTCase_ArgI
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00102 OTCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00658 orni_carb_tr, 1 hit
PROSITEiView protein in PROSITE
PS00097 CARBAMOYLTRANSFERASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q7NGR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASLGATRF RPDLLSLDDL DEAQLHALLT LAHQLKRGER VANLHGKVLG
60 70 80 90 100
LVFLKASTRT RVSFTVAMYQ LGGQVIDLSP SNTQVGRGEP VRDTARVLGR
110 120 130 140 150
YVDGLAIRTF AQTELEEYAH YAGIPVINAL TDHEHPCQVV ADLLTIRENF
160 170 180 190 200
GRLAGLKLAY VGDGNNVAHS LLLGCAKVGM SIAVATPEGF TPDPAVSARA
210 220 230 240 250
SEIAGRTGAE VQILRDPFEA ARGAHILYTD VWTSMGQEAE TQHRLQLFEQ
260 270 280 290 300
YQINAALLNC AAAEAIVLHC LPAHRGEEIT DEVMEGPRSR IWDEAENRLH
310
AQKAVLAALM GGR
Length:313
Mass (Da):33,958
Last modified:December 15, 2003 - v1
Checksum:i705948D76BE67854
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA Translation: BAC91042.1
RefSeqiNP_926047.1, NC_005125.1
WP_011143094.1, NC_005125.1

Genome annotation databases

EnsemblBacteriaiBAC91042; BAC91042; BAC91042
GeneIDi2601502
KEGGigvi:gvip429
PATRICifig|251221.4.peg.3130

Similar proteinsi

Entry informationi

Entry nameiOTC_GLOVI
AccessioniPrimary (citable) accession number: Q7NGR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 15, 2003
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health