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Q7NGR7 (OTC_GLOVI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ornithine carbamoyltransferase

Short name=OTCase
EC=2.1.3.3
Gene names
Name:argF
Ordered Locus Names:gll3101
OrganismGloeobacter violaceus (strain PCC 7421) [Reference proteome] [HAMAP]
Taxonomic identifier251221 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline By similarity. HAMAP-Rule MF_01109

Catalytic activity

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP-Rule MF_01109

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP-Rule MF_01109

Subunit structure

Homohexamer. Ref.2

Subcellular location

Cytoplasm Probable HAMAP-Rule MF_01109.

Sequence similarities

Belongs to the ATCase/OTCase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionamino acid binding

Inferred from electronic annotation. Source: InterPro

ornithine carbamoyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Ornithine carbamoyltransferase HAMAP-Rule MF_01109
PRO_0000112927

Regions

Region57 – 615Carbamoyl phosphate binding By similarity
Region135 – 1384Carbamoyl phosphate binding By similarity
Region234 – 2352Ornithine binding By similarity
Region269 – 2724Carbamoyl phosphate binding By similarity

Sites

Binding site151Carbamoyl phosphate By similarity
Binding site731Carbamoyl phosphate By similarity
Binding site841Carbamoyl phosphate By similarity
Binding site1081Carbamoyl phosphate By similarity
Binding site1661Ornithine By similarity
Binding site2301Ornithine By similarity
Binding site2801Carbamoyl phosphate By similarity
Binding site2981Carbamoyl phosphate By similarity
Site361Important for structural integrity By similarity
Site1481Important for structural integrity By similarity

Secondary structure

................................................. 313
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q7NGR7 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 705948D76BE67854

FASTA31333,958
        10         20         30         40         50         60 
MSASLGATRF RPDLLSLDDL DEAQLHALLT LAHQLKRGER VANLHGKVLG LVFLKASTRT 

        70         80         90        100        110        120 
RVSFTVAMYQ LGGQVIDLSP SNTQVGRGEP VRDTARVLGR YVDGLAIRTF AQTELEEYAH 

       130        140        150        160        170        180 
YAGIPVINAL TDHEHPCQVV ADLLTIRENF GRLAGLKLAY VGDGNNVAHS LLLGCAKVGM 

       190        200        210        220        230        240 
SIAVATPEGF TPDPAVSARA SEIAGRTGAE VQILRDPFEA ARGAHILYTD VWTSMGQEAE 

       250        260        270        280        290        300 
TQHRLQLFEQ YQINAALLNC AAAEAIVLHC LPAHRGEEIT DEVMEGPRSR IWDEAENRLH 

       310 
AQKAVLAALM GGR 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome structure of Gloeobacter violaceus PCC 7421, a cyanobacterium that lacks thylakoids."
Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T., Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M., Tabata S.
DNA Res. 10:137-145(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7421.
[2]"Crystal structure of ornithine carbamoyltransferase from Gloeobacter violaceus."
New york sgx research center for structural genomics (NYSGXRC)
Fedorov A.A., Fedorov E.V., Toro R., Ramagopal U.A., Sauder J.M., Burley S.K., Almo S.C.
Submitted (FEB-2009) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS), SUBUNIT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000045 Genomic DNA. Translation: BAC91042.1.
RefSeqNP_926047.1. NC_005125.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3GD5X-ray2.10A/B/C/D/E/F2-313[»]
ProteinModelPortalQ7NGR7.
SMRQ7NGR7. Positions 12-312.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING251221.gvip429.

Proteomic databases

PRIDEQ7NGR7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC91042; BAC91042; BAC91042.
GeneID2601502.
KEGGgvi:gvip429.
PATRIC22045673. VBIGloVio86258_3130.

Phylogenomic databases

eggNOGCOG0078.
KOK00611.
OMAKWAEQNA.
OrthoDBEOG690MGV.
PhylomeDBQ7NGR7.

Enzyme and pathway databases

BioCycGVIO251221:GH9A-3139-MONOMER.
UniPathwayUPA00068; UER00112.

Family and domain databases

Gene3D3.40.50.1370. 2 hits.
HAMAPMF_01109. OTCase.
InterProIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view]
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMSSF53671. SSF53671. 1 hit.
TIGRFAMsTIGR00658. orni_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ7NGR7.

Entry information

Entry nameOTC_GLOVI
AccessionPrimary (citable) accession number: Q7NGR7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways