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Q7NGR7

- OTC_GLOVI

UniProt

Q7NGR7 - OTC_GLOVI

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Protein

Ornithine carbamoyltransferase

Gene
argF, gll3101
Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline By similarity.UniRule annotation

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151Carbamoyl phosphate By similarity
Sitei36 – 361Important for structural integrity By similarity
Binding sitei73 – 731Carbamoyl phosphate By similarity
Binding sitei84 – 841Carbamoyl phosphate By similarity
Binding sitei108 – 1081Carbamoyl phosphate By similarity
Sitei148 – 1481Important for structural integrity By similarity
Binding sitei166 – 1661Ornithine By similarity
Binding sitei230 – 2301Ornithine By similarity
Binding sitei280 – 2801Carbamoyl phosphate By similarity
Binding sitei298 – 2981Carbamoyl phosphate By similarity

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. ornithine carbamoyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-3139-MONOMER.
UniPathwayiUPA00068; UER00112.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferase (EC:2.1.3.3)
Short name:
OTCase
Gene namesi
Name:argF
Ordered Locus Names:gll3101
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
ProteomesiUP000000557: Chromosome

Subcellular locationi

Cytoplasm Inferred UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Ornithine carbamoyltransferaseUniRule annotationPRO_0000112927Add
BLAST

Proteomic databases

PRIDEiQ7NGR7.

Interactioni

Subunit structurei

Homohexamer.1 Publication

Protein-protein interaction databases

STRINGi251221.gvip429.

Structurei

Secondary structure

1
313
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi14 – 163
Helixi17 – 193
Helixi22 – 3615
Beta strandi48 – 558
Helixi58 – 7013
Beta strandi74 – 785
Helixi91 – 988
Turni99 – 1013
Beta strandi103 – 1086
Helixi112 – 12211
Beta strandi126 – 1305
Helixi136 – 15015
Beta strandi157 – 1626
Helixi166 – 17712
Beta strandi181 – 1855
Helixi194 – 20714
Beta strandi211 – 2155
Helixi217 – 2215
Beta strandi225 – 2295
Helixi245 – 2484
Helixi255 – 2595
Beta strandi266 – 2694
Turni276 – 2783
Helixi281 – 2855
Helixi291 – 31020

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3GD5X-ray2.10A/B/C/D/E/F2-313[»]
ProteinModelPortaliQ7NGR7.
SMRiQ7NGR7. Positions 12-312.

Miscellaneous databases

EvolutionaryTraceiQ7NGR7.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni57 – 615Carbamoyl phosphate binding By similarity
Regioni135 – 1384Carbamoyl phosphate binding By similarity
Regioni234 – 2352Ornithine binding By similarity
Regioni269 – 2724Carbamoyl phosphate binding By similarity

Sequence similaritiesi

Belongs to the ATCase/OTCase family.

Phylogenomic databases

eggNOGiCOG0078.
KOiK00611.
OMAiKWAEQNA.
OrthoDBiEOG690MGV.
PhylomeDBiQ7NGR7.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_01109. OTCase.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7NGR7-1 [UniParc]FASTAAdd to Basket

« Hide

MSASLGATRF RPDLLSLDDL DEAQLHALLT LAHQLKRGER VANLHGKVLG    50
LVFLKASTRT RVSFTVAMYQ LGGQVIDLSP SNTQVGRGEP VRDTARVLGR 100
YVDGLAIRTF AQTELEEYAH YAGIPVINAL TDHEHPCQVV ADLLTIRENF 150
GRLAGLKLAY VGDGNNVAHS LLLGCAKVGM SIAVATPEGF TPDPAVSARA 200
SEIAGRTGAE VQILRDPFEA ARGAHILYTD VWTSMGQEAE TQHRLQLFEQ 250
YQINAALLNC AAAEAIVLHC LPAHRGEEIT DEVMEGPRSR IWDEAENRLH 300
AQKAVLAALM GGR 313
Length:313
Mass (Da):33,958
Last modified:December 15, 2003 - v1
Checksum:i705948D76BE67854
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC91042.1.
RefSeqiNP_926047.1. NC_005125.1.
WP_011143094.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC91042; BAC91042; BAC91042.
GeneIDi2601502.
KEGGigvi:gvip429.
PATRICi22045673. VBIGloVio86258_3130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC91042.1 .
RefSeqi NP_926047.1. NC_005125.1.
WP_011143094.1. NC_005125.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3GD5 X-ray 2.10 A/B/C/D/E/F 2-313 [» ]
ProteinModelPortali Q7NGR7.
SMRi Q7NGR7. Positions 12-312.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 251221.gvip429.

Proteomic databases

PRIDEi Q7NGR7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC91042 ; BAC91042 ; BAC91042 .
GeneIDi 2601502.
KEGGi gvi:gvip429.
PATRICi 22045673. VBIGloVio86258_3130.

Phylogenomic databases

eggNOGi COG0078.
KOi K00611.
OMAi KWAEQNA.
OrthoDBi EOG690MGV.
PhylomeDBi Q7NGR7.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00112 .
BioCyci GVIO251221:GH9A-3139-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q7NGR7.

Family and domain databases

Gene3Di 3.40.50.1370. 2 hits.
HAMAPi MF_01109. OTCase.
InterProi IPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view ]
Pfami PF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view ]
PRINTSi PR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMi SSF53671. SSF53671. 1 hit.
TIGRFAMsi TIGR00658. orni_carb_tr. 1 hit.
PROSITEi PS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7421.
  2. "Crystal structure of ornithine carbamoyltransferase from Gloeobacter violaceus."
    New york sgx research center for structural genomics (NYSGXRC)
    Fedorov A.A., Fedorov E.V., Toro R., Ramagopal U.A., Sauder J.M., Burley S.K., Almo S.C.
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS), SUBUNIT.

Entry informationi

Entry nameiOTC_GLOVI
AccessioniPrimary (citable) accession number: Q7NGR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 15, 2003
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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