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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi495 – 4951MagnesiumUniRule annotation
Metal bindingi501 – 5011MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-3188-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:gll3149
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
ProteomesiUP000000557 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 713713Polyribonucleotide nucleotidyltransferasePRO_0000329664Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi251221.gll3149.

Structurei

3D structure databases

ProteinModelPortaliQ7NGM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini562 – 62160KHUniRule annotationAdd
BLAST
Domaini631 – 70070S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
InParanoidiQ7NGM0.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiEOG6WT8CC.
PhylomeDBiQ7NGM0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF13014. KH_3. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7NGM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEYRKSVTV HGREIGLSTG VLAQLAGGSV LVQSGETAVL VTATMASKPR
60 70 80 90 100
EGIDFFPLLV DYEERLYAAG RIPGSFVRRE GRPPEKAILA ARLIDRPLRP
110 120 130 140 150
LFPKGFINDV QIVATVLALD MNVPPDILAI LGASTATMLA GIPFDGPVAA
160 170 180 190 200
TRVGLMGDDF IINPTYKEIE EGELDLVVAG TKNGIMMVEA GANCLPEEDI
210 220 230 240 250
IDAIDYGYEA VQAMLTAQEE FIRDLKIEPM AFVAPANDPV LVSFVEEKAS
260 270 280 290 300
EAVAEVLRSF ELSKDERDAK LDAIEAELGT TFAGLGEEDP LREKAAANAS
310 320 330 340 350
KLPALFKSTT KKLMRKQILV EGKRVDGRSL DEVRPISSAV RVIPRVHGCG
360 370 380 390 400
LFTRGTTQVL SVVTLGTASD AQELDDLHPD DSKRYMHHYN FPGFSVGEVK
410 420 430 440 450
PLRGVGRREV GHGALAERAI VPILPEHEQF PYVIRVVSEV LSSNGSTSMG
460 470 480 490 500
SVCASTLALM DAGVPIREPV SGVAMGLIKE GDEVRILTDI QGIEDFLGDM
510 520 530 540 550
DFKVAGTRDG ITALQMDIKI QGITLQILEA AIQQSKAGRL HILEKMLIAI
560 570 580 590 600
DKPRVELSPY APRLLTLKIP VDMIGLVIGP GGKTIKRIVE ETGAKVDIED
610 620 630 640 650
DGTVVVSSID GAKALAAKQI IEGMTRTVEV DKVYLGTVTR IIPNLGAFVE
660 670 680 690 700
VMPGKEGLVH ISQLAEHRVR KVEDELNVGD EVVVKVKEID QKGRINLTRR
710
GIHPSEVEEA RGQ
Length:713
Mass (Da):77,078
Last modified:December 15, 2003 - v1
Checksum:iB55C4E0396C51E32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA. Translation: BAC91090.1.
RefSeqiNP_926095.1. NC_005125.1.
WP_011143141.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC91090; BAC91090; BAC91090.
GeneIDi2601550.
KEGGigvi:gll3149.
PATRICi22045775. VBIGloVio86258_3180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA. Translation: BAC91090.1.
RefSeqiNP_926095.1. NC_005125.1.
WP_011143141.1. NC_005125.1.

3D structure databases

ProteinModelPortaliQ7NGM0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi251221.gll3149.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC91090; BAC91090; BAC91090.
GeneIDi2601550.
KEGGigvi:gll3149.
PATRICi22045775. VBIGloVio86258_3180.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
InParanoidiQ7NGM0.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiEOG6WT8CC.
PhylomeDBiQ7NGM0.

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-3188-MONOMER.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF13014. KH_3. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7421.

Entry informationi

Entry nameiPNP_GLOVI
AccessioniPrimary (citable) accession number: Q7NGM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 15, 2003
Last modified: April 1, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.