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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.

Cofactori

NAD+Note: Binds 1 NAD+ per subunit.

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei62Substrate1
Binding sitei134Substrate1
Binding sitei159Substrate1
Binding sitei189Substrate1
Binding sitei193Substrate1
Binding sitei194NAD1
Binding sitei246NAD1
Binding sitei281NAD1
Binding sitei349NAD1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi160 – 162NAD3
Nucleotide bindingi223 – 228NAD6
Nucleotide bindingi302 – 304NAD3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylhomocysteinase (EC:3.3.1.1)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolase
Short name:
AdoHcyase
Gene namesi
Name:ahcY
Ordered Locus Names:glr3183
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacteraceaeGloeobacter
Proteomesi
  • UP000000557 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001169641 – 428AdenosylhomocysteinaseAdd BLAST428

Interactioni

Protein-protein interaction databases

STRINGi251221.glr3183.

Structurei

3D structure databases

ProteinModelPortaliQ7NGI6.
SMRiQ7NGI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.

Phylogenomic databases

eggNOGiENOG4105C3E. Bacteria.
COG0499. LUCA.
HOGENOMiHOG000227987.
InParanoidiQ7NGI6.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG091H00W2.
PhylomeDBiQ7NGI6.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 2 hits.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7NGI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAVKTPIQV RYEVRNLELA AEGRQRIEWA AREMPVLKQL RQRFSQERPL
60 70 80 90 100
AGIRISACCH VTTETANLAV ALKAAGADAL LIASNPLSTQ DDVAASLVVD
110 120 130 140 150
HGIPVFALKG EDTATYLRHV RVALDHRPQI IIDDGSDVVA TMIKDRPDLI
160 170 180 190 200
AGVIGTTEET TTGIVRLKAM LAAGVLTFPA MAVNDAETKH FFDNRYGTGQ
210 220 230 240 250
STLDGIIRAT NILLAGKTIV VAGYGWCGKG VALRARGMGA NVVVTEINPV
260 270 280 290 300
RAIEAAMDGL QVMPMAEAAC LGDLFITVTG NKHVIRREHF AMMKDGAIVC
310 320 330 340 350
NSGHFDIEID LVALGELSSE RRMVRPFTEE YTLEGGKSVI VLGEGRLINL
360 370 380 390 400
AAAEGHPASV MDMSFANQAL AVEYLIKNQG KLSPGIYNIP EELDRQIAAL
410 420
KLAAMGIAID TLTPDQLHYI SSWDEGTE
Length:428
Mass (Da):46,150
Last modified:December 15, 2003 - v1
Checksum:i55B8B09585998B9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA. Translation: BAC91124.1.
RefSeqiNP_926129.1. NC_005125.1.
WP_011143175.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC91124; BAC91124; BAC91124.
GeneIDi2601584.
KEGGigvi:glr3183.
PATRICifig|251221.4.peg.3213.

Similar proteinsi

Entry informationi

Entry nameiSAHH_GLOVI
AccessioniPrimary (citable) accession number: Q7NGI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 15, 2003
Last modified: October 25, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families