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Q7NG92 (UPPP_GLOVI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:glr3281
OrganismGloeobacter violaceus (strain PCC 7421) [Reference proteome] [HAMAP]
Taxonomic identifier251221 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151155

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane44 – 6421Helical; Potential
Transmembrane88 – 10821Helical; Potential
Transmembrane122 – 14221Helical; Potential
Transmembrane152 – 17221Helical; Potential
Transmembrane195 – 21521Helical; Potential
Transmembrane226 – 24621Helical; Potential
Transmembrane255 – 27521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q7NG92 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: BC3BB50B524C7B1C

FASTA29030,881
        10         20         30         40         50         60 
MQQQIGIFEA IVLGFVQGIT EYFPISSTAH LRVVPALLGW ADPGTAYSAV IQLGSLLAVL 

        70         80         90        100        110        120 
TYFYKDLVEI LSGTVRALRT GDTQSREVRL FWGIILGTIP IVIAGLALKS TLEAPGSPLR 

       130        140        150        160        170        180 
ALSVIAVASI VMAALLWLSE SLGKRTRTMK GIRVIDGILI GCAQALALVP GVSRSGSTLT 

       190        200        210        220        230        240 
AALFLGFQRA DGARFSFLLA IPAIFLSGLL ELKVLVDEGF SGGIGPIVAG FVSSTVFSYL 

       250        260        270        280        290 
AIAWLLKFLQ TRSTLVFVIY RFFFGALLLG LLAAGLLPDI EPVRQALNLP 

« Hide

References

[1]"Complete genome structure of Gloeobacter violaceus PCC 7421, a cyanobacterium that lacks thylakoids."
Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T., Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M., Tabata S.
DNA Res. 10:137-145(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7421.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000045 Genomic DNA. Translation: BAC91222.1.
RefSeqNP_926227.1. NC_005125.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING251221.glr3281.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC91222; BAC91222; BAC91222.
GeneID2601683.
KEGGgvi:glr3281.
PATRIC22046047. VBIGloVio86258_3313.

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAFNDAHAK.
OrthoDBEOG6QP13M.
PhylomeDBQ7NG92.

Enzyme and pathway databases

BioCycGVIO251221:GH9A-3324-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_GLOVI
AccessionPrimary (citable) accession number: Q7NG92
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families