Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q7NG34 (GLO2_GLOVI)

Last modified February 9, 2010. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Hydroxyacylglutathione hydrolase
    EC=3.1.2.6
Alternative name(s):
    Glyoxalase II
      Short name=Glx II
Gene names
Name: gloB
Ordered Locus Names: gll3339
OrganismGloeobacter violaceus [Complete proteome] [HAMAP]
Taxonomic identifier33072 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Gloeobacteria › Gloeobacterales › Gloeobacter

Hide | Top

Protein attributes

Sequence length252 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

Hide | Top

General annotation (Comments)

Function

Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid By similarity. HAMAP MF_01374

Catalytic activity

S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. HAMAP MF_01374

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP MF_01374

Pathway

Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2. HAMAP MF_01374

Subunit structure

Monomer By similarity. HAMAP MF_01374

Sequence similarities

Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

Hide | Top

Ontologies

Keywords
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionhydroxyacylglutathione hydrolase activity

Inferred from electronic annotation. Source: HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 252252Hydroxyacylglutathione hydrolase HAMAP MF_01374
PRO_1000068218

Sites

Metal binding541Zinc 1 By similarity
Metal binding561Zinc 1 By similarity
Metal binding581Zinc 2 By similarity
Metal binding591Zinc 2 By similarity
Metal binding1131Zinc 1 By similarity
Metal binding1321Zinc 1 By similarity
Metal binding1321Zinc 2 By similarity
Metal binding1701Zinc 2 By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q7NG34-1 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: A04D505AA86DE2E3

FASTA25228,123
        10         20         30         40         50         60 
MLVHRLNALK DNYVFVLEDE AARTAAVVDP AEARPVLEAL VRLGLKLVAI FNTHHHHDHV 

        70         80         90        100        110        120 
GGNRELLEAY PGIAVYASRR DRGRIPGQTV ELEDGDTVAF GCERARVIFV PGHTHGHIAY 

       130        140        150        160        170        180 
HFAGCGHLFC GDTLFAGGCG RLFEGTARQM QHSLGRLREL PGETQVWCAH EYTLGNLRFA 

       190        200        210        220        230        240 
HTLEPDNAEL AERLRTVEVL RARKIATVPS TMAAERATNP FLRWESRQLQ RAAGAIEPEE 

       250 
VFAHLRALKD RF

« Hide

Hide | Top

References

[1]"Complete genome structure of Gloeobacter violaceus PCC 7421, a cyanobacterium that lacks thylakoids."
Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T., Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M., Tabata S.
DNA Res. 10:137-145(2003) [PubMed: 14621292] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7421.

Hide | Top

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000045 Genomic DNA. Translation: BAC91280.1.
RefSeqNP_926285.1.

3D structure databases

HSSPHSSP built from PDB template 1XM8 based on UniProtKB Q9SID3.
ModBaseSearch...

Genome annotation databases

GeneID2601742.
GenomeReviewsGene locus gll3339 in contig BA000045_GR.
KEGGgvi:gll3339.
NMPDRfig|251221.1.peg.3339.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG753931.
OMAWCAHEYT.

Enzyme and pathway databases

BioCycGVIO251221:GLL3339-MONOMER.
BRENDA3.1.2.6. 276183.

Family and domain databases

HAMAPMF_01374. Glyoxalase_2.
[Tree]
InterProIPR001279. Blactmase-like.
IPR017782. Hydroxyacylglutathione_Hdrlase.
[Graphical view]
SMARTSM00849. Lactamase_B. 1 hit.
[Graphical view]
TIGRFAMsTIGR03413. GSH_gloB. 1 hit.
ProtoNetSearch...

Hide | Top

Entry information

Entry nameGLO2_GLOVI
AccessionPrimary (citable) accession number: Q7NG34
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 15, 2003
Last modified: February 9, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Hide | Top

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents