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Q7NFK0 (NADK2_GLOVI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase 2

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase 2
Gene names
Name:nadK2
Ordered Locus Names:gll3525
OrganismGloeobacter violaceus (strain PCC 7421) [Reference proteome] [HAMAP]
Taxonomic identifier251221 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309NAD kinase 2 HAMAP-Rule MF_00361
PRO_0000229642

Regions

Nucleotide binding81 – 822NAD By similarity
Nucleotide binding155 – 1562NAD By similarity
Nucleotide binding196 – 2016NAD By similarity

Sites

Active site811Proton acceptor By similarity
Binding site1851NAD By similarity
Binding site2551NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7NFK0 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 99235657C6FCB72F

FASTA30933,606
        10         20         30         40         50         60 
MMALPKAGII FNDIKPAAAR AAAELTEKFQ DAGYRVYQTT GWGGILGFPR PDSPVCHTPI 

        70         80         90        100        110        120 
DRLAAEGFDE AMPFAIVLGG DGTVLAAARQ VAPFDIPLLT INTGHMGFLT EGYLNQIHPA 

       130        140        150        160        170        180 
IDTLLAGQYA LEDRSMIEVR VFRDERLIWE ALALNEAVLH KEPLSGICHF EVAIGRHNIV 

       190        200        210        220        230        240 
DIAADGVIVA TPTGSTAYAL SAGGPVITPD VQVLQLIPIC PHSLAARGLV FADTESLVVH 

       250        260        270        280        290        300 
PPTNHQHLIL SLDGNSGCYI WPGDQVRIRR ARYRTRLIRL QPPEFFALLR EKLGWGLPHI 


AKPLSVELP 

« Hide

References

[1]"Complete genome structure of Gloeobacter violaceus PCC 7421, a cyanobacterium that lacks thylakoids."
Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T., Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M., Tabata S.
DNA Res. 10:137-145(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7421.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000045 Genomic DNA. Translation: BAC91466.1.
RefSeqNP_926471.1. NC_005125.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING251221.gll3525.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC91466; BAC91466; BAC91466.
GeneID2601929.
KEGGgvi:gll3525.
PATRIC22046541. VBIGloVio86258_3558.

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000227222.
KOK00858.
OMATHEMLYH.
OrthoDBEOG6PZXDR.
PhylomeDBQ7NFK0.

Enzyme and pathway databases

BioCycGVIO251221:GH9A-3572-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK2_GLOVI
AccessionPrimary (citable) accession number: Q7NFK0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families