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Q7NFK0

- NADK2_GLOVI

UniProt

Q7NFK0 - NADK2_GLOVI

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Protein

NAD kinase 2

Gene

nadK2

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei81 – 811Proton acceptorUniRule annotation
Binding sitei185 – 1851NADUniRule annotation
Binding sitei255 – 2551NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi81 – 822NADUniRule annotation
Nucleotide bindingi155 – 1562NADUniRule annotation
Nucleotide bindingi196 – 2016NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-3572-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 2UniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinase 2UniRule annotation
Gene namesi
Name:nadK2UniRule annotation
Ordered Locus Names:gll3525
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
ProteomesiUP000000557: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309NAD kinase 2PRO_0000229642Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi251221.gll3525.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
InParanoidiQ7NFK0.
KOiK00858.
OMAiTHEMLYH.
OrthoDBiEOG6PZXDR.
PhylomeDBiQ7NFK0.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7NFK0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMALPKAGII FNDIKPAAAR AAAELTEKFQ DAGYRVYQTT GWGGILGFPR
60 70 80 90 100
PDSPVCHTPI DRLAAEGFDE AMPFAIVLGG DGTVLAAARQ VAPFDIPLLT
110 120 130 140 150
INTGHMGFLT EGYLNQIHPA IDTLLAGQYA LEDRSMIEVR VFRDERLIWE
160 170 180 190 200
ALALNEAVLH KEPLSGICHF EVAIGRHNIV DIAADGVIVA TPTGSTAYAL
210 220 230 240 250
SAGGPVITPD VQVLQLIPIC PHSLAARGLV FADTESLVVH PPTNHQHLIL
260 270 280 290 300
SLDGNSGCYI WPGDQVRIRR ARYRTRLIRL QPPEFFALLR EKLGWGLPHI

AKPLSVELP
Length:309
Mass (Da):33,606
Last modified:December 15, 2003 - v1
Checksum:i99235657C6FCB72F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA. Translation: BAC91466.1.
RefSeqiNP_926471.1. NC_005125.1.
WP_011143514.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC91466; BAC91466; BAC91466.
GeneIDi2601929.
KEGGigvi:gll3525.
PATRICi22046541. VBIGloVio86258_3558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA. Translation: BAC91466.1 .
RefSeqi NP_926471.1. NC_005125.1.
WP_011143514.1. NC_005125.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 251221.gll3525.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC91466 ; BAC91466 ; BAC91466 .
GeneIDi 2601929.
KEGGi gvi:gll3525.
PATRICi 22046541. VBIGloVio86258_3558.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
InParanoidi Q7NFK0.
KOi K00858.
OMAi THEMLYH.
OrthoDBi EOG6PZXDR.
PhylomeDBi Q7NFK0.

Enzyme and pathway databases

BioCyci GVIO251221:GH9A-3572-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7421.

Entry informationi

Entry nameiNADK2_GLOVI
AccessioniPrimary (citable) accession number: Q7NFK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 15, 2003
Last modified: November 26, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3