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Q7NFJ9

- LIPA2_GLOVI

UniProt

Q7NFJ9 - LIPA2_GLOVI

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Protein

Lipoyl synthase 2

Gene
lipA2, gll3526
Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives By similarity.UniRule annotation

Catalytic activityi

Protein N(6)-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine.UniRule annotation

Cofactori

Binds 2 4Fe-4S clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi43 – 431Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi48 – 481Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi54 – 541Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi69 – 691Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi73 – 731Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi76 – 761Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
  2. lipoate synthase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. protein lipoylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-3573-MONOMER.
UniPathwayiUPA00538; UER00593.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoyl synthase 2 (EC:2.8.1.8)
Alternative name(s):
Lip-syn 2
Lipoate synthase 2
Lipoic acid synthase 2
Sulfur insertion protein lipA2
Gene namesi
Name:lipA2
Ordered Locus Names:gll3526
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
ProteomesiUP000000557: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Lipoyl synthase 2UniRule annotationPRO_0000102317Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi251221.gll3526.

Structurei

3D structure databases

ProteinModelPortaliQ7NFJ9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0320.
HOGENOMiHOG000235998.
KOiK03644.
OMAiEWLRRPI.
OrthoDBiEOG6038ZS.
PhylomeDBiQ7NFJ9.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00206. Lipoyl_synth.
InterProiIPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view]
PANTHERiPTHR10949. PTHR10949. 1 hit.
PfamiPF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFiPIRSF005963. Lipoyl_synth. 1 hit.
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00510. lipA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7NFJ9-1 [UniParc]FASTAAdd to Basket

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MLAMSHQTAS SRLPEWARRT IGTASQVSTV EKIVKQRSLH TICEEGRCPN    50
RAECYAQKTA TFLLMGPVCT RACGFCQVAG GKALPLDPQE PEKVAEAVAL 100
LGLKYVVLTS VARDDLPDQG AGWFVRTMES IRARNCAVEI EVLTPDFRGE 150
EACIATVVAA RPVCFNHNIE TVRRLQSYAR RAATYARSLA VLAAVKRLDA 200
EIFTKSGLML GHGETREEVL ETLLDLRKVG CDRVTLGQYL QPSKDHLPVH 250
KYWTPAEFAE LGAVARDLGF AHVRSGPLVR SSYHAGEPE 289
Length:289
Mass (Da):31,777
Last modified:December 15, 2003 - v1
Checksum:i37A1CD474D675519
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC91467.1.
RefSeqiNP_926472.1. NC_005125.1.
WP_011143515.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC91467; BAC91467; BAC91467.
GeneIDi2601930.
KEGGigvi:gll3526.
PATRICi22046543. VBIGloVio86258_3559.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC91467.1 .
RefSeqi NP_926472.1. NC_005125.1.
WP_011143515.1. NC_005125.1.

3D structure databases

ProteinModelPortali Q7NFJ9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 251221.gll3526.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC91467 ; BAC91467 ; BAC91467 .
GeneIDi 2601930.
KEGGi gvi:gll3526.
PATRICi 22046543. VBIGloVio86258_3559.

Phylogenomic databases

eggNOGi COG0320.
HOGENOMi HOG000235998.
KOi K03644.
OMAi EWLRRPI.
OrthoDBi EOG6038ZS.
PhylomeDBi Q7NFJ9.

Enzyme and pathway databases

UniPathwayi UPA00538 ; UER00593 .
BioCyci GVIO251221:GH9A-3573-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00206. Lipoyl_synth.
InterProi IPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view ]
PANTHERi PTHR10949. PTHR10949. 1 hit.
Pfami PF04055. Radical_SAM. 1 hit.
[Graphical view ]
PIRSFi PIRSF005963. Lipoyl_synth. 1 hit.
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00510. lipA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7421.

Entry informationi

Entry nameiLIPA2_GLOVI
AccessioniPrimary (citable) accession number: Q7NFJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: December 15, 2003
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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