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Q7NF44

- GSHB_GLOVI

UniProt

Q7NF44 - GSHB_GLOVI

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Protein
Glutathione synthetase
Gene
gshB, gll3682
Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi284 – 2841Magnesium or manganese By similarity
Metal bindingi286 – 2861Magnesium or manganese By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi155 – 21157ATP By similarity
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutathione synthase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Glutathione biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciGVIO251221:GH9A-3731-MONOMER.
    UniPathwayiUPA00142; UER00210.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione synthetase (EC:6.3.2.3)
    Alternative name(s):
    GSH synthetase
    Short name:
    GSH-S
    Short name:
    GSHase
    Glutathione synthase
    Gene namesi
    Name:gshB
    Ordered Locus Names:gll3682
    OrganismiGloeobacter violaceus (strain PCC 7421)
    Taxonomic identifieri251221 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
    ProteomesiUP000000557: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: InterPro
    Complete GO annotation...

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 324324Glutathione synthetaseUniRule annotation
    PRO_0000197468Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi251221.gvip498.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7NF44.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini129 – 313185ATP-grasp
    Add
    BLAST

    Sequence similaritiesi

    Contains 1 ATP-grasp domain.

    Phylogenomic databases

    eggNOGiCOG0189.
    KOiK01920.
    OMAiEISTKQG.
    OrthoDBiEOG6WMHWB.
    PhylomeDBiQ7NF44.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    HAMAPiMF_00162. GSH_S.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR006284. Glut_synth_pro.
    IPR004218. GSHS_ATP-bd.
    IPR004215. GSHS_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view]
    PfamiPF02955. GSH-S_ATP. 1 hit.
    PF02951. GSH-S_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF52440. SSF52440. 1 hit.
    TIGRFAMsiTIGR01380. glut_syn. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7NF44-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKILFIVDPL ETLKPGHDTS VALMQAAARR GHSVWAAEVG DLQVHHHRAA    50
    AQVRTLTIHP GRTPFYTVEA VGFYPLSEAD VIWMRKDPPV TSAYLWATQV 100
    LDLVNAGRGD GRTTFVLNRP SGLRNDNEKL YALHFPDLVP ETRVCTHRQD 150
    ILDFVDIHGR AVIKPLDGKG GEGIFLLARA DRNLNAIIEA STAYGTRHVM 200
    VQRYLEESRQ GDKRIVLLAG EPIGALLRVP REDDVRGNMA AGGRVVKTTL 250
    TERDREICRV VGPRLVADGH YFVGIDVIGA YLTEINVTSP TGICEIDVLD 300
    GVVLEDEIVD WLVEYTRPAL ARNL 324
    Length:324
    Mass (Da):35,906
    Last modified:December 15, 2003 - v1
    Checksum:i7D3277C55E838EAF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC91623.1.
    RefSeqiNP_926628.1. NC_005125.1.
    WP_011143671.1. NC_005125.1.

    Genome annotation databases

    EnsemblBacteriaiBAC91623; BAC91623; BAC91623.
    GeneIDi2602086.
    KEGGigvi:gvip498.
    PATRICi22046861. VBIGloVio86258_3716.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC91623.1 .
    RefSeqi NP_926628.1. NC_005125.1.
    WP_011143671.1. NC_005125.1.

    3D structure databases

    ProteinModelPortali Q7NF44.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 251221.gvip498.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC91623 ; BAC91623 ; BAC91623 .
    GeneIDi 2602086.
    KEGGi gvi:gvip498.
    PATRICi 22046861. VBIGloVio86258_3716.

    Phylogenomic databases

    eggNOGi COG0189.
    KOi K01920.
    OMAi EISTKQG.
    OrthoDBi EOG6WMHWB.
    PhylomeDBi Q7NF44.

    Enzyme and pathway databases

    UniPathwayi UPA00142 ; UER00210 .
    BioCyci GVIO251221:GH9A-3731-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    HAMAPi MF_00162. GSH_S.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR006284. Glut_synth_pro.
    IPR004218. GSHS_ATP-bd.
    IPR004215. GSHS_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view ]
    Pfami PF02955. GSH-S_ATP. 1 hit.
    PF02951. GSH-S_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52440. SSF52440. 1 hit.
    TIGRFAMsi TIGR01380. glut_syn. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7421.

    Entry informationi

    Entry nameiGSHB_GLOVI
    AccessioniPrimary (citable) accession number: Q7NF44
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: December 15, 2003
    Last modified: September 3, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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