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Protein

Acetylornithine aminotransferase

Gene

argD

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationNote: Binds 1 pyridoxal phosphate per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei165 – 1651Pyridoxal phosphate; via carbonyl oxygenUniRule annotation
Binding sitei168 – 1681N2-acetyl-L-ornithineUniRule annotation
Binding sitei316 – 3161N2-acetyl-L-ornithineUniRule annotation
Binding sitei317 – 3171Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-3899-MONOMER.
UniPathwayiUPA00068; UER00109.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine aminotransferaseUniRule annotation (EC:2.6.1.11UniRule annotation)
Short name:
ACOATUniRule annotation
Gene namesi
Name:argDUniRule annotation
Ordered Locus Names:glr3849Imported
OrganismiGloeobacter violaceus (strain PCC 7421)Imported
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
ProteomesiUP000000557: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei289 – 2891N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi251221.glr3849.

Structurei

3D structure databases

ProteinModelPortaliQ7NEN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni260 – 2634Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000020206.
KOiK00823.
OMAiLLHMSGT.
OrthoDBiEOG6QVRHN.
PhylomeDBiQ7NEN0.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01107. ArgD_aminotrans_3.
InterProiIPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7NEN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLPTKEAS LPRVPRLVGP LPGPRAQALI ARDEAVTSPS YTRGYPLVAA
60 70 80 90 100
RGEGCMLEDV DGNVFLDLTA GIAVTATGHA HPVVVRAIQE QAANLLHMSG
110 120 130 140 150
TDFYYEPMAE LAEALCERAP FPTAAGRPRA RVFFSNSGAE SNEGALKLAR
160 170 180 190 200
YYTGRQQVVA FLGAFHGRTY GAMSLTGSRA VQRQGFGPLV PGISHIPYGT
210 220 230 240 250
HASLDYLEDK LFPAVLPPEE IAAIVVESIQ GEGGYIVPED GFHERIRQIC
260 270 280 290 300
TRHGILMVVD EVQAGMGRTG KLFAIEHWGV QPDIVTLAKG IASGLPLGAI
310 320 330 340 350
LSRPEIMTWP AGSHATTFGG NPVACAAANA TLKLLEAGLI ENAERMGRVL
360 370 380 390 400
QAGLGQLADR FSFVSASRGK GLMVAVDLFD AAGNLDRERR DQIVDLAFYR
410 420 430
GLLLLGCGKA AIRFCPPLVI DADQVRVALD ILRQIFEEQ
Length:439
Mass (Da):46,990
Last modified:December 15, 2003 - v1
Checksum:iC5BB680D1D21ED14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA. Translation: BAC91790.1.
RefSeqiNP_926795.1. NC_005125.1.
WP_011143837.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC91790; BAC91790; BAC91790.
GeneIDi2602252.
KEGGigvi:glr3849.
PATRICi22047201. VBIGloVio86258_3884.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA. Translation: BAC91790.1.
RefSeqiNP_926795.1. NC_005125.1.
WP_011143837.1. NC_005125.1.

3D structure databases

ProteinModelPortaliQ7NEN0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi251221.glr3849.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC91790; BAC91790; BAC91790.
GeneIDi2602252.
KEGGigvi:glr3849.
PATRICi22047201. VBIGloVio86258_3884.

Phylogenomic databases

HOGENOMiHOG000020206.
KOiK00823.
OMAiLLHMSGT.
OrthoDBiEOG6QVRHN.
PhylomeDBiQ7NEN0.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00109.
BioCyciGVIO251221:GH9A-3899-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01107. ArgD_aminotrans_3.
InterProiIPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7421Imported.

Entry informationi

Entry nameiQ7NEN0_GLOVI
AccessioniPrimary (citable) accession number: Q7NEN0
Entry historyi
Integrated into UniProtKB/TrEMBL: December 15, 2003
Last sequence update: December 15, 2003
Last modified: March 4, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.