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Q7NEK3 (HEM6_GLOVI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Coproporphyrinogen-III oxidase, aerobic
Short name=Coprogen oxidase
Short name=Coproporphyrinogenase
EC=1.3.3.3
Gene names
Name:hemF
Ordered Locus Names:gll3876
OrganismGloeobacter violaceus (strain PCC 7421)
Taxonomic identifier251221 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Gloeobacteria › Gloeobacterales › Gloeobacter

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. HAMAP MF_00333

Catalytic activity

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. HAMAP MF_00333

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. HAMAP MF_00333

Subunit structure

Homodimer By similarity. HAMAP MF_00333

Subcellular location

Cytoplasm By similarity HAMAP MF_00333.

Sequence similarities

Belongs to the aerobic coproporphyrinogen-III oxidase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncoproporphyrinogen oxidase activity

Inferred from electronic annotation. Source: EC

protein homodimerization activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Coproporphyrinogen-III oxidase, aerobic HAMAP MF_00333
PRO_0000109898

Regions

Region38 – 4710Important for dimerization By similarity
Region98 – 1003Substrate binding By similarity
Region224 – 25936Important for dimerization By similarity
Region242 – 2476Substrate binding By similarity

Sites

Active site961Proton donor By similarity
Binding site821Substrate By similarity
Site1601Important for dimerization By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7NEK3 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 36285EE9D7B1AB78

FASTA28933,577
        10         20         30         40         50         60 
MQSLQDNITS RLEAVDGEGR FVEDLWEREE GGGGRSRILT EGRVFERAGI GFSEVHGSHL 

        70         80         90        100        110        120 
PPSILQQRPE AEGHPFYVTG TSMVLHPRNP YVPTVHLNYR YFEAGPVWWF GGGADLTPYY 

       130        140        150        160        170        180 
GFVEDAAHFH ATLKAACDAH DPEYYPRFKK WCDEYFYLKH RQEPRGVGGI FFDYVQGDWE 

       190        200        210        220        230        240 
KIFAFAQSCG NAFLPAYLPI VERRHTLPYA ERERNFQLYR RGRYVEFNLV WDRGTIFGLQ 

       250        260        270        280 
TNGRIESILM SMPPLVRWEY NYRPEPGTAE AELYEVFLVP QDWASQAKR

« Hide

References

[1]"Complete genome structure of Gloeobacter violaceus PCC 7421, a cyanobacterium that lacks thylakoids."
Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T., Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M., Tabata S.
DNA Res. 10:137-145(2003) [PubMed: 14621292] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7421.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000045 Genomic DNA. Translation: BAC91817.1.
RefSeqNP_926822.1. NC_005125.1.

3D structure databases

ProteinModelPortalQ7NEK3.
SMRQ7NEK3. Positions 1-284.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2602279.
GenomeReviewsGene locus gll3876 in contig BA000045_GR.
NMPDRfig|251221.1.peg.3876.
PATRIC22047255. VBIGloVio86258_3911.

Phylogenomic databases

HOGENOMHBG631180.
OMAYLFEEDC.
PhylomeDBQ7NEK3.
ProtClustDBPRK05330.

Enzyme and pathway databases

BioCycGVIO251221:GLL3876-MONOMER.

Family and domain databases

HAMAPMF_00333. Coprogen_oxidas.
[Tree]
InterProIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
Gene3DG3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
PANTHERPTHR10755. Coprogen_oxidas. 1 hit.
PfamPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PIRSFPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSPR00073. COPRGNOXDASE.
SUPFAMSSF102886. Coprogen_oxidas. 1 hit.
PROSITEPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEM6_GLOVI
AccessionPrimary (citable) accession number: Q7NEK3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: December 15, 2003
Last modified: January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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