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Q7NE10

- SPEA_GLOVI

UniProt

Q7NE10 - SPEA_GLOVI

Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

    Catalytic activityi

    L-arginine = agmatine + CO2.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation
    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. arginine decarboxylase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginine catabolic process Source: InterPro
    2. spermidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Polyamine biosynthesis, Spermidine biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding, Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciGVIO251221:GH9A-4121-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
    Short name:
    ADCUniRule annotation
    Gene namesi
    Name:speAUniRule annotation
    Ordered Locus Names:gll4070
    OrganismiGloeobacter violaceus (strain PCC 7421)
    Taxonomic identifieri251221 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
    ProteomesiUP000000557: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 644644Biosynthetic arginine decarboxylasePRO_0000149963Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei100 – 1001N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi251221.gll4070.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7NE10.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni282 – 29211Substrate-bindingUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1166.
    HOGENOMiHOG000029191.
    KOiK01585.
    OMAiIDHYVDG.
    OrthoDBiEOG676Z0R.
    PhylomeDBiQ7NE10.

    Family and domain databases

    Gene3Di2.40.37.10. 2 hits.
    3.20.20.10. 1 hit.
    HAMAPiMF_01417. SpeA.
    InterProiIPR009006. Ala_racemase/Decarboxylase_C.
    IPR002985. Arg_decrbxlase.
    IPR022643. De-COase2_C.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
    PRINTSiPR01180. ARGDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR01273. speA. 1 hit.
    PROSITEiPS00878. ODR_DC_2_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7NE10-1 [UniParc]FASTAAdd to Basket

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    MQDWTIEDSA ELYQIHGWGE PYFKINDKGH VAVMPRGEGN GEIDLFHLVQ    50
    DIQKRGLNMP MLIRFSDILA DRIARLNACF VEAIREYDYP GIYKGVYPVK 100
    VNQQRHVVEE VVEFGRPFQY GLEAGSKPEL LIALATLKTP GALIICNGYK 150
    DSEYIETALL AQRLGHTPFV VIERFHELTL LIEAAQKLGI RPLIGVRAKL 200
    TARGIGRWGD STGDRAKFGL SAGEIMEVVA QLKAADLLSS LQLLHFHIGS 250
    QISAINVIKT ALREASCVYV ELAQMGAPMQ YCDVGGGLAI DYDGSKTNFR 300
    ASKNYNMQEY AYDVVAAFQD ACRTKNVPVP TLVSESGRAI TSHQSVLVFD 350
    VMGVSHLQFG EPEPPARNEH SIIRNLYETY TQITPDNVQE AFNDASQFKE 400
    EALSLFALGY LGLGERARAE RLYWGCCEKI LNLVRELDYI PDELADLEKN 450
    MASTYYCNFS VFQSAPDSWA IDQLFPIMPI HRLDEEPKAR GTLADLTCDS 500
    DGKIDQFIDL RDVKGVLELH PVRPEEPYYL GMFLNGAYQE ILGDMHNLFG 550
    DTNTVHIHLA SDEPGEQSYR LEHVVKGDTM TEVLKYVQYD HEAMLESIRR 600
    ETEQALRERR ITLSESRLLL QHYERSLSGY TYLTNELQVE LAAR 644
    Length:644
    Mass (Da):72,694
    Last modified:December 15, 2003 - v1
    Checksum:iB70B2C69C7B352A2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC92011.1.
    RefSeqiNP_927016.1. NC_005125.1.
    WP_011144058.1. NC_005125.1.

    Genome annotation databases

    EnsemblBacteriaiBAC92011; BAC92011; BAC92011.
    GeneIDi2602453.
    KEGGigvi:gll4070.
    PATRICi22047639. VBIGloVio86258_4102.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC92011.1 .
    RefSeqi NP_927016.1. NC_005125.1.
    WP_011144058.1. NC_005125.1.

    3D structure databases

    ProteinModelPortali Q7NE10.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 251221.gll4070.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC92011 ; BAC92011 ; BAC92011 .
    GeneIDi 2602453.
    KEGGi gvi:gll4070.
    PATRICi 22047639. VBIGloVio86258_4102.

    Phylogenomic databases

    eggNOGi COG1166.
    HOGENOMi HOG000029191.
    KOi K01585.
    OMAi IDHYVDG.
    OrthoDBi EOG676Z0R.
    PhylomeDBi Q7NE10.

    Enzyme and pathway databases

    BioCyci GVIO251221:GH9A-4121-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 2 hits.
    3.20.20.10. 1 hit.
    HAMAPi MF_01417. SpeA.
    InterProi IPR009006. Ala_racemase/Decarboxylase_C.
    IPR002985. Arg_decrbxlase.
    IPR022643. De-COase2_C.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
    PRINTSi PR01180. ARGDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR01273. speA. 1 hit.
    PROSITEi PS00878. ODR_DC_2_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7421.

    Entry informationi

    Entry nameiSPEA_GLOVI
    AccessioniPrimary (citable) accession number: Q7NE10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3