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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation
  • pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-4121-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:gll4070
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
ProteomesiUP000000557 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 644644Biosynthetic arginine decarboxylasePRO_0000149963Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei100 – 1001N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi251221.gll4070.

Structurei

3D structure databases

ProteinModelPortaliQ7NE10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni282 – 29211Substrate-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
InParanoidiQ7NE10.
KOiK01585.
OMAiVRFVCDR.
OrthoDBiEOG676Z0R.
PhylomeDBiQ7NE10.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PANTHERiPTHR11482:SF36. PTHR11482:SF36. 1 hit.
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7NE10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDWTIEDSA ELYQIHGWGE PYFKINDKGH VAVMPRGEGN GEIDLFHLVQ
60 70 80 90 100
DIQKRGLNMP MLIRFSDILA DRIARLNACF VEAIREYDYP GIYKGVYPVK
110 120 130 140 150
VNQQRHVVEE VVEFGRPFQY GLEAGSKPEL LIALATLKTP GALIICNGYK
160 170 180 190 200
DSEYIETALL AQRLGHTPFV VIERFHELTL LIEAAQKLGI RPLIGVRAKL
210 220 230 240 250
TARGIGRWGD STGDRAKFGL SAGEIMEVVA QLKAADLLSS LQLLHFHIGS
260 270 280 290 300
QISAINVIKT ALREASCVYV ELAQMGAPMQ YCDVGGGLAI DYDGSKTNFR
310 320 330 340 350
ASKNYNMQEY AYDVVAAFQD ACRTKNVPVP TLVSESGRAI TSHQSVLVFD
360 370 380 390 400
VMGVSHLQFG EPEPPARNEH SIIRNLYETY TQITPDNVQE AFNDASQFKE
410 420 430 440 450
EALSLFALGY LGLGERARAE RLYWGCCEKI LNLVRELDYI PDELADLEKN
460 470 480 490 500
MASTYYCNFS VFQSAPDSWA IDQLFPIMPI HRLDEEPKAR GTLADLTCDS
510 520 530 540 550
DGKIDQFIDL RDVKGVLELH PVRPEEPYYL GMFLNGAYQE ILGDMHNLFG
560 570 580 590 600
DTNTVHIHLA SDEPGEQSYR LEHVVKGDTM TEVLKYVQYD HEAMLESIRR
610 620 630 640
ETEQALRERR ITLSESRLLL QHYERSLSGY TYLTNELQVE LAAR
Length:644
Mass (Da):72,694
Last modified:December 15, 2003 - v1
Checksum:iB70B2C69C7B352A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA. Translation: BAC92011.1.
RefSeqiNP_927016.1. NC_005125.1.
WP_011144058.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC92011; BAC92011; BAC92011.
GeneIDi2602453.
KEGGigvi:gll4070.
PATRICi22047639. VBIGloVio86258_4102.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA. Translation: BAC92011.1.
RefSeqiNP_927016.1. NC_005125.1.
WP_011144058.1. NC_005125.1.

3D structure databases

ProteinModelPortaliQ7NE10.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi251221.gll4070.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC92011; BAC92011; BAC92011.
GeneIDi2602453.
KEGGigvi:gll4070.
PATRICi22047639. VBIGloVio86258_4102.

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
InParanoidiQ7NE10.
KOiK01585.
OMAiVRFVCDR.
OrthoDBiEOG676Z0R.
PhylomeDBiQ7NE10.

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-4121-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PANTHERiPTHR11482:SF36. PTHR11482:SF36. 1 hit.
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7421.

Entry informationi

Entry nameiSPEA_GLOVI
AccessioniPrimary (citable) accession number: Q7NE10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: December 15, 2003
Last modified: June 24, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.