Q7NE10 (SPEA_GLOVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Biosynthetic arginine decarboxylase
Short name=ADC
EC=4.1.1.19

Gene names

Name:	speA
Ordered Locus Names:	gll4070

Organism

Gloeobacter violaceus (strain PCC 7421)

Taxonomic identifier

251221 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Gloeobacteria › Gloeobacterales › Gloeobacter

Protein attributes

Sequence length	644 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP MF_01417
Catalytic activity	L-arginine = agmatine + CO2. HAMAP MF_01417
Cofactor	Magnesium By similarity. HAMAP MF_01417 Pyridoxal phosphate By similarity. HAMAP MF_01417
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Ontologies

Keywords
Biological process	Polyamine biosynthesis Spermidine biosynthesis
Ligand	Magnesium Metal-binding Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro spermidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 644	644	Biosynthetic arginine decarboxylase HAMAP MF_01417		PRO_0000149963
Regions
	Region	282 – 292	11	Substrate-binding Potential
Amino acid modifications
	Modified residue	100	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7NE10 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: B70B2C69C7B352A2	FASTA	644	72,694
	10 20 30 40 50 60 MQDWTIEDSA ELYQIHGWGE PYFKINDKGH VAVMPRGEGN GEIDLFHLVQ DIQKRGLNMP 70 80 90 100 110 120 MLIRFSDILA DRIARLNACF VEAIREYDYP GIYKGVYPVK VNQQRHVVEE VVEFGRPFQY 130 140 150 160 170 180 GLEAGSKPEL LIALATLKTP GALIICNGYK DSEYIETALL AQRLGHTPFV VIERFHELTL 190 200 210 220 230 240 LIEAAQKLGI RPLIGVRAKL TARGIGRWGD STGDRAKFGL SAGEIMEVVA QLKAADLLSS 250 260 270 280 290 300 LQLLHFHIGS QISAINVIKT ALREASCVYV ELAQMGAPMQ YCDVGGGLAI DYDGSKTNFR 310 320 330 340 350 360 ASKNYNMQEY AYDVVAAFQD ACRTKNVPVP TLVSESGRAI TSHQSVLVFD VMGVSHLQFG 370 380 390 400 410 420 EPEPPARNEH SIIRNLYETY TQITPDNVQE AFNDASQFKE EALSLFALGY LGLGERARAE 430 440 450 460 470 480 RLYWGCCEKI LNLVRELDYI PDELADLEKN MASTYYCNFS VFQSAPDSWA IDQLFPIMPI 490 500 510 520 530 540 HRLDEEPKAR GTLADLTCDS DGKIDQFIDL RDVKGVLELH PVRPEEPYYL GMFLNGAYQE 550 560 570 580 590 600 ILGDMHNLFG DTNTVHIHLA SDEPGEQSYR LEHVVKGDTM TEVLKYVQYD HEAMLESIRR 610 620 630 640 ETEQALRERR ITLSESRLLL QHYERSLSGY TYLTNELQVE LAAR

References

[1]

"Complete genome structure of Gloeobacter violaceus PCC 7421, a cyanobacterium that lacks thylakoids." Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T., Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M., Tabata S. DNA Res. 10:137-145(2003) [PubMed: 14621292] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7421.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000045 Genomic DNA. Translation: BAC92011.1.
RefSeq	NP_927016.1. NC_005125.1.
3D structure databases
ProteinModelPortal	Q7NE10.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2602453.
GenomeReviews	Gene locus gll4070 in contig BA000045_GR.
KEGG	gvi:gll4070.
NMPDR	fig|251221.1.peg.4070.
PATRIC	22047639. VBIGloVio86258_4102.
Phylogenomic databases
HOGENOM	HBG321436.
OMA	LICNGYK.
PhylomeDB	Q7NE10.
ProtClustDB	PRK05354.
Enzyme and pathway databases
BioCyc	GVIO251221:GLL4070-MONOMER.
Family and domain databases
HAMAP	MF_01417. SpeA. [Tree]
InterPro	IPR009006. Ala_racemase/Decarboxylase_C. IPR002985. Arg_decrbxlase. IPR022643. De-COase2_C. IPR022644. De-COase2_N. IPR022653. De-COase2_pyr-phos_BS. IPR000183. Orn/DAP/Arg_de-COase. [Graphical view]
Gene3D	G3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 2 hits.
KO	K01585.
PANTHER	PTHR11482:SF3. Arg_decrbxlase. 1 hit.
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PIRSF	PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTS	PR01180. ARGDCRBXLASE. PR01179. ODADCRBXLASE.
TIGRFAMs	TIGR01273. SpeA. 1 hit.
PROSITE	PS00878. ODR_DC_2_1. 1 hit. PS00879. ODR_DC_2_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPEA_GLOVI

Accession

Primary (citable) accession number: Q7NE10

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program