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Q7NE01

- SYL_GLOVI

UniProt

Q7NE01 - SYL_GLOVI

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Protein

Leucine--tRNA ligase

Gene
leuS, gll4081
Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei616 – 6161ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-4132-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:gll4081
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
ProteomesiUP000000557: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 847847Leucine--tRNA ligaseUniRule annotationPRO_0000152021Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi251221.gvip546.

Structurei

3D structure databases

ProteinModelPortaliQ7NE01.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi39 – 4911"HIGH" regionUniRule annotationAdd
BLAST
Motifi613 – 6175"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.
PhylomeDBiQ7NE01.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7NE01-1 [UniParc]FASTAAdd to Basket

« Hide

METRYNPHAI EPRRQKQWEE APHLAMDGRP KFYALSMFPY PSGALHMGHV    50
RNYSITDVIS RYKRMRGFNV LHPIGWDAFG LPAENAAIDR GIHPAQWTEQ 100
NIAQMREQLK RLGFAYAWER EVATCSPAYY RWTQKLFLEF WKAGLAYRKA 150
GVVNWDPVDQ TVLANEQVDA EGRSWRSGAL VEKRPLEQWY LKITDYAEEL 200
LQALGTLGDW PERVRVMQEN WIGKSVGAEL CFPINGEPEG IRVFTTRPDT 250
VYGVTYLVLA PEHPLVERIT APERREAVRA FVAQVQSESE IERVSEDRPK 300
QGVSTGAVAL NPFTGQAVPV WIADYVLFEY GTGAVMGVPG HDERDFVFAS 350
QYELPIRLVV QAPDGSLTEP LRAAYTEVGV LVNSGPFNGL DSPTGKLKIV 400
EYAEQQGWGK GRVQYRLRDW LISRQRYWGC PIPMVYCPEC GVVPVPDEQL 450
PVALPGDVEF SGRGPSPLAK LEGWICVDCP QCGAPARRET DTMDTFIDSS 500
WYFLRFADAR NGAEPFSREA VDYWLPVDQY VGGIEHAILH LLYSRFFTKV 550
LRDRGLLSFD EPFKRLLTQG MVLSNAFVDP ATKKYYPPDQ VEERGGAFFA 600
RPDGTPLVCA MEKMSKSKYN GIDPLTVRSE YGADTARLFV LFKAPPEKEL 650
EWSDADVRGQ YSFLGRVWRT VYEFVSGEKP DRPVGEAQER DLRREVHRAI 700
QQVGGDIEQY KFNTAIAALM KLNNAMADYP SGQSPAYKEG VYVIVKLLAP 750
FAPHIGAELW QALGEAGDIH TSDWPALDES ALVEETIVLV IQVNGKKRDD 800
IQVPAAASEG ELQELALASE AVRRHTDGKA IKKVIVVPGR LINLVVG 847
Length:847
Mass (Da):95,295
Last modified:December 15, 2003 - v1
Checksum:i4C53540A83DA7029
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC92022.1.
RefSeqiNP_927027.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC92022; BAC92022; BAC92022.
GeneIDi2602464.
KEGGigvi:gvip546.
PATRICi22047661. VBIGloVio86258_4113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC92022.1 .
RefSeqi NP_927027.1. NC_005125.1.

3D structure databases

ProteinModelPortali Q7NE01.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 251221.gvip546.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC92022 ; BAC92022 ; BAC92022 .
GeneIDi 2602464.
KEGGi gvi:gvip546.
PATRICi 22047661. VBIGloVio86258_4113.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.
PhylomeDBi Q7NE01.

Enzyme and pathway databases

BioCyci GVIO251221:GH9A-4132-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7421.

Entry informationi

Entry nameiSYL_GLOVI
AccessioniPrimary (citable) accession number: Q7NE01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi