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Q7NE01

- SYL_GLOVI

UniProt

Q7NE01 - SYL_GLOVI

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei616 – 6161ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciGVIO251221:GH9A-4132-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:gll4081
    OrganismiGloeobacter violaceus (strain PCC 7421)
    Taxonomic identifieri251221 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
    ProteomesiUP000000557: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 847847Leucine--tRNA ligasePRO_0000152021Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi251221.gvip546.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7NE01.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi39 – 4911"HIGH" regionAdd
    BLAST
    Motifi613 – 6175"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.
    PhylomeDBiQ7NE01.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7NE01-1 [UniParc]FASTAAdd to Basket

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    METRYNPHAI EPRRQKQWEE APHLAMDGRP KFYALSMFPY PSGALHMGHV    50
    RNYSITDVIS RYKRMRGFNV LHPIGWDAFG LPAENAAIDR GIHPAQWTEQ 100
    NIAQMREQLK RLGFAYAWER EVATCSPAYY RWTQKLFLEF WKAGLAYRKA 150
    GVVNWDPVDQ TVLANEQVDA EGRSWRSGAL VEKRPLEQWY LKITDYAEEL 200
    LQALGTLGDW PERVRVMQEN WIGKSVGAEL CFPINGEPEG IRVFTTRPDT 250
    VYGVTYLVLA PEHPLVERIT APERREAVRA FVAQVQSESE IERVSEDRPK 300
    QGVSTGAVAL NPFTGQAVPV WIADYVLFEY GTGAVMGVPG HDERDFVFAS 350
    QYELPIRLVV QAPDGSLTEP LRAAYTEVGV LVNSGPFNGL DSPTGKLKIV 400
    EYAEQQGWGK GRVQYRLRDW LISRQRYWGC PIPMVYCPEC GVVPVPDEQL 450
    PVALPGDVEF SGRGPSPLAK LEGWICVDCP QCGAPARRET DTMDTFIDSS 500
    WYFLRFADAR NGAEPFSREA VDYWLPVDQY VGGIEHAILH LLYSRFFTKV 550
    LRDRGLLSFD EPFKRLLTQG MVLSNAFVDP ATKKYYPPDQ VEERGGAFFA 600
    RPDGTPLVCA MEKMSKSKYN GIDPLTVRSE YGADTARLFV LFKAPPEKEL 650
    EWSDADVRGQ YSFLGRVWRT VYEFVSGEKP DRPVGEAQER DLRREVHRAI 700
    QQVGGDIEQY KFNTAIAALM KLNNAMADYP SGQSPAYKEG VYVIVKLLAP 750
    FAPHIGAELW QALGEAGDIH TSDWPALDES ALVEETIVLV IQVNGKKRDD 800
    IQVPAAASEG ELQELALASE AVRRHTDGKA IKKVIVVPGR LINLVVG 847
    Length:847
    Mass (Da):95,295
    Last modified:December 15, 2003 - v1
    Checksum:i4C53540A83DA7029
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC92022.1.
    RefSeqiNP_927027.1. NC_005125.1.

    Genome annotation databases

    EnsemblBacteriaiBAC92022; BAC92022; BAC92022.
    GeneIDi2602464.
    KEGGigvi:gvip546.
    PATRICi22047661. VBIGloVio86258_4113.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC92022.1 .
    RefSeqi NP_927027.1. NC_005125.1.

    3D structure databases

    ProteinModelPortali Q7NE01.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 251221.gvip546.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC92022 ; BAC92022 ; BAC92022 .
    GeneIDi 2602464.
    KEGGi gvi:gvip546.
    PATRICi 22047661. VBIGloVio86258_4113.

    Phylogenomic databases

    eggNOGi COG0495.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.
    PhylomeDBi Q7NE01.

    Enzyme and pathway databases

    BioCyci GVIO251221:GH9A-4132-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7421.

    Entry informationi

    Entry nameiSYL_GLOVI
    AccessioniPrimary (citable) accession number: Q7NE01
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3