##gff-version 3
Q7NDN8	UniProtKB	Signal peptide	1	43	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q7NDN8	UniProtKB	Chain	44	359	.	.	.	ID=PRO_0000412722;Note=Proton-gated ion channel	
Q7NDN8	UniProtKB	Topological domain	44	235	.	.	.	Note=Periplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q7NDN8	UniProtKB	Transmembrane	236	258	.	.	.	Note=Helical	
Q7NDN8	UniProtKB	Topological domain	259	261	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q7NDN8	UniProtKB	Transmembrane	262	286	.	.	.	Note=Helical	
Q7NDN8	UniProtKB	Topological domain	287	294	.	.	.	Note=Periplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q7NDN8	UniProtKB	Transmembrane	295	323	.	.	.	Note=Helical	
Q7NDN8	UniProtKB	Topological domain	324	326	.	.	.	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q7NDN8	UniProtKB	Transmembrane	327	359	.	.	.	Note=Helical	
Q7NDN8	UniProtKB	Mutagenesis	244	244	.	.	.	Note=Marked gain of function%2C with a ten-fold shift of the proton dose-response curve towards lower concentrations. I->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248852;Dbxref=PMID:21248852	
Q7NDN8	UniProtKB	Mutagenesis	264	264	.	.	.	Note=Decreases cation selectivity. Decreases the binding affinity of TEA and TBA. Nearly abolishes block by Cd(2+). E->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18987630,ECO:0000269|PubMed:21037567;Dbxref=PMID:18987630,PMID:21037567	
Q7NDN8	UniProtKB	Mutagenesis	264	264	.	.	.	Note=Decreases binding affinity of TBA. E->Q%2CD;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18987630,ECO:0000269|PubMed:21037567;Dbxref=PMID:18987630,PMID:21037567	
Q7NDN8	UniProtKB	Mutagenesis	268	268	.	.	.	Note=Increases the binding affinity of TBA. Weakens block by Cd(2+). T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21037567;Dbxref=PMID:21037567	
Q7NDN8	UniProtKB	Mutagenesis	272	272	.	.	.	Note=Increases the binding affinity of TBA. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21037567;Dbxref=PMID:21037567	
Q7NDN8	UniProtKB	Mutagenesis	284	284	.	.	.	Note=Displays an increased sensitivity to propofol but not to desflurane. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248852;Dbxref=PMID:21248852	
Q7NDN8	UniProtKB	Mutagenesis	297	297	.	.	.	Note=Marked gain of function%2C with a ten-fold shift of the proton dose-response curve towards lower concentrations. Shows also slower apparent rate constants for activation and deactivation. Displays an increased sensitivity to propofol but a decreased sensitivity to desflurane. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248852;Dbxref=PMID:21248852	
Q7NDN8	UniProtKB	Beta strand	53	55	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HZW	
Q7NDN8	UniProtKB	Beta strand	58	73	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HZW	
Q7NDN8	UniProtKB	Turn	74	77	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HZW	
Q7NDN8	UniProtKB	Beta strand	78	90	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HZW	
Q7NDN8	UniProtKB	Helix	92	94	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HZW	
Q7NDN8	UniProtKB	Helix	98	101	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HZW	
Q7NDN8	UniProtKB	Beta strand	104	107	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6F0U	
Q7NDN8	UniProtKB	Turn	110	112	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HZW	
Q7NDN8	UniProtKB	Beta strand	118	125	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HZW	
Q7NDN8	UniProtKB	Beta strand	128	136	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HZW	
Q7NDN8	UniProtKB	Turn	138	140	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HZ0	
Q7NDN8	UniProtKB	Beta strand	141	153	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HZW	
Q7NDN8	UniProtKB	Turn	159	162	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HZW	
Q7NDN8	UniProtKB	Beta strand	165	175	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HZW	
Q7NDN8	UniProtKB	Beta strand	178	180	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5NJY	
Q7NDN8	UniProtKB	Beta strand	182	186	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HZW	
Q7NDN8	UniProtKB	Helix	188	190	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HZW	
Q7NDN8	UniProtKB	Beta strand	192	194	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IGQ	
Q7NDN8	UniProtKB	Beta strand	196	199	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IGQ	
Q7NDN8	UniProtKB	Beta strand	202	218	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HZW	
Q7NDN8	UniProtKB	Beta strand	221	234	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HZW	
Q7NDN8	UniProtKB	Helix	236	238	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IUX	
Q7NDN8	UniProtKB	Helix	239	242	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HZW	
Q7NDN8	UniProtKB	Helix	244	254	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HZW	
Q7NDN8	UniProtKB	Helix	255	259	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HZW	
Q7NDN8	UniProtKB	Helix	263	286	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HZW	
Q7NDN8	UniProtKB	Helix	296	323	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HZW	
Q7NDN8	UniProtKB	Helix	327	356	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HZW