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Q7NDN8

- GLIC_GLOVI

UniProt

Q7NDN8 - GLIC_GLOVI

Protein

Proton-gated ion channel

Gene

glvI

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Cationic channel with similar permeabilities for Na+ and K+, that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.1 Publication

    Enzyme regulationi

    Tetraethylammonium (TEA) and tetrabutylammonium (TBA) inhibit the proton-activated currents in a dose- and voltage-dependent manner in vitro, whereas the blocker of acid sensing ion channels, amiloride, has no effect. Channel current of GLIC can be inhibited by inhaled and intravenous general anesthetics at and below concentrations used clinically. Ion conduction is also inhibited by lidocaine and by divalent transition metal ions such as cadmium ions.3 Publications

    GO - Molecular functioni

    1. extracellular ligand-gated ion channel activity Source: InterPro
    2. potassium channel activity Source: UniProtKB-KW
    3. sodium channel activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Potassium channel, Receptor, Sodium channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Sodium transport, Transport

    Keywords - Ligandi

    Potassium, Sodium

    Enzyme and pathway databases

    BioCyciGVIO251221:GH9A-4249-MONOMER.

    Protein family/group databases

    TCDBi1.A.9.8.1. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proton-gated ion channel
    Alternative name(s):
    GLIC
    Ligand-gated ion channel
    Short name:
    LGIC
    Gene namesi
    Name:glvI
    Ordered Locus Names:glr4197
    OrganismiGloeobacter violaceus (strain PCC 7421)
    Taxonomic identifieri251221 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
    ProteomesiUP000000557: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi244 – 2441I → Y: Marked gain of function, with a ten-fold shift of the proton dose-response curve towards lower concentrations. 2 Publications
    Mutagenesisi264 – 2641E → A: Decreases cation selectivity. Decreases the binding affinity of TEA and TBA. Nearly abolishes block by Cd(2+). 3 Publications
    Mutagenesisi264 – 2641E → Q or D: Decreases binding affinity of TBA. 3 Publications
    Mutagenesisi268 – 2681T → A: Increases the binding affinity of TBA. Weakens block by Cd(2+). 2 Publications
    Mutagenesisi272 – 2721S → A: Increases the binding affinity of TBA. 2 Publications
    Mutagenesisi284 – 2841V → M: Displays an increased sensitivity to propofol but not to desflurane. 2 Publications
    Mutagenesisi297 – 2971T → A: Marked gain of function, with a ten-fold shift of the proton dose-response curve towards lower concentrations. Shows also slower apparent rate constants for activation and deactivation. Displays an increased sensitivity to propofol but a decreased sensitivity to desflurane. 2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4343Sequence AnalysisAdd
    BLAST
    Chaini44 – 359316Proton-gated ion channelPRO_0000412722Add
    BLAST

    Interactioni

    Subunit structurei

    Homopentamer.3 Publications

    Protein-protein interaction databases

    DIPiDIP-59040N.
    MINTiMINT-8425450.
    STRINGi251221.glr4197.

    Structurei

    Secondary structure

    1
    359
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi53 – 553
    Beta strandi58 – 7013
    Beta strandi76 – 9015
    Helixi92 – 943
    Helixi98 – 1014
    Beta strandi104 – 1074
    Helixi110 – 1123
    Beta strandi118 – 1269
    Beta strandi128 – 1369
    Turni138 – 1403
    Beta strandi141 – 15313
    Turni159 – 1624
    Beta strandi165 – 17410
    Beta strandi177 – 1793
    Beta strandi182 – 1865
    Helixi188 – 1903
    Beta strandi192 – 1943
    Beta strandi196 – 1994
    Beta strandi202 – 21211
    Beta strandi219 – 2213
    Beta strandi225 – 23410
    Helixi236 – 2383
    Helixi239 – 2424
    Helixi244 – 25411
    Helixi255 – 2595
    Helixi263 – 28624
    Helixi296 – 32328
    Helixi327 – 35630

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2XQ3X-ray3.50A/B/C/D/E43-359[»]
    2XQ4X-ray3.60A/B/C/D/E43-359[»]
    2XQ5X-ray3.50A/B/C/D/E43-359[»]
    2XQ6X-ray3.70A/B/C/D/E43-359[»]
    2XQ7X-ray3.40A/B/C/D/E43-359[»]
    2XQ8X-ray3.60A/B/C/D/E43-359[»]
    2XQ9X-ray3.20A/B/C/D/E43-359[»]
    2XQAX-ray3.70A/B/C/D/E43-359[»]
    3EAMX-ray2.90A/B/C/D/E44-359[»]
    3EHZX-ray3.10A/B/C/D/E50-359[»]
    3EI0X-ray3.50A/B/C/D/E50-359[»]
    3IGQX-ray2.30A/B/C/D/E/F44-235[»]
    3LSVX-ray3.15A/B/C/D/E44-359[»]
    3P4WX-ray3.20A/B/C/D/E44-359[»]
    3P50X-ray3.30A/B/C/D/E44-359[»]
    3TLSX-ray3.20A/B/C/D/E44-359[»]
    3TLTX-ray3.30A/B/C/D/E44-359[»]
    3TLUX-ray2.85A/B/C/D/E44-359[»]
    3TLVX-ray2.90A/B/C/D/E44-359[»]
    3TLWX-ray2.60A/B/C/D/E44-359[»]
    3UU3X-ray3.15A/B/C/D/E44-359[»]
    3UU4X-ray3.05A/B/C/D/E44-359[»]
    3UU5X-ray2.90A/B/C/D/E44-359[»]
    3UU6X-ray2.98A/B/C/D/E44-359[»]
    3UU8X-ray3.25A/B/C/D/E44-359[»]
    3UUBX-ray2.90A/B/C/D/E/F/G/H/I/J44-359[»]
    4F8HX-ray2.99A/B/C/D/E43-359[»]
    4HFBX-ray2.75A/B/C/D/E44-359[»]
    4HFCX-ray3.05A/B/C/D/E44-359[»]
    4HFDX-ray3.10A/B/C/D/E44-359[»]
    4HFEX-ray2.80A/B/C/D/E44-359[»]
    4HFHX-ray2.65A/B/C/D/E44-359[»]
    4HFIX-ray2.40A/B/C/D/E44-359[»]
    4IL4X-ray3.30A/B/C/D/E44-359[»]
    4IL9X-ray2.83A/B/C/D/E44-358[»]
    4ILAX-ray3.50A/B/C/D/E44-358[»]
    4ILBX-ray3.15A/B/C/D/E44-358[»]
    4ILCX-ray2.99A/B/C/D/E44-358[»]
    4IREX-ray3.19A/B/C/D/E43-359[»]
    4LMJX-ray3.44A/B/C/D/E44-359[»]
    4LMKX-ray3.22A/B/C/D/E44-359[»]
    4LMLX-ray3.80A/B/C/D/E44-359[»]
    4NPPX-ray3.35A/B/C/D/E44-359[»]
    4NPQX-ray4.35A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T44-359[»]
    ProteinModelPortaliQ7NDN8.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ7NDN8.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini44 – 235192PeriplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 2613CytoplasmicSequence Analysis
    Topological domaini287 – 2948PeriplasmicSequence Analysis
    Topological domaini324 – 3263CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei236 – 25823HelicalAdd
    BLAST
    Transmembranei262 – 28625HelicalAdd
    BLAST
    Transmembranei295 – 32329HelicalAdd
    BLAST
    Transmembranei327 – 35933HelicalAdd
    BLAST

    Family & Domainsi

    Domaini

    Consists of an N-terminal ligand-binding domain that encloses a wide aqueous vestibule and a transmembrane domain that forms a narrow channel.

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    OMAiFTYEASF.
    OrthoDBiEOG6VF30W.
    PhylomeDBiQ7NDN8.

    Family and domain databases

    Gene3Di2.70.170.10. 1 hit.
    InterProiIPR006028. GABAA/Glycine_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR00253. GABAARECEPTR.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7NDN8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFPTGWRPKL SESIAASRML WQPMAAVAVV QIGLLWFSPP VWGQDMVSPP    50
    PPIADEPLTV NTGIYLIECY SLDDKAETFK VNAFLSLSWK DRRLAFDPVR 100
    SGVRVKTYEP EAIWIPEIRF VNVENARDAD VVDISVSPDG TVQYLERFSA 150
    RVLSPLDFRR YPFDSQTLHI YLIVRSVDTR NIVLAVDLEK VGKNDDVFLT 200
    GWDIESFTAV VKPANFALED RLESKLDYQL RISRQYFSYI PNIILPMLFI 250
    LFISWTAFWS TSYEANVTLV VSTLIAHIAF NILVETNLPK TPYMTYTGAI 300
    IFMIYLFYFV AVIEVTVQHY LKVESQPARA ASITRASRIA FPVVFLLANI 350
    ILAFLFFGF 359
    Length:359
    Mass (Da):40,986
    Last modified:December 15, 2003 - v1
    Checksum:i6F9009F96172C025
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC92138.1.
    RefSeqiNP_927143.1. NC_005125.1.
    WP_011144181.1. NC_005125.1.

    Genome annotation databases

    EnsemblBacteriaiBAC92138; BAC92138; BAC92138.
    GeneIDi2602600.
    KEGGigvi:glr4197.
    PATRICi22047895. VBIGloVio86258_4229.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC92138.1 .
    RefSeqi NP_927143.1. NC_005125.1.
    WP_011144181.1. NC_005125.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2XQ3 X-ray 3.50 A/B/C/D/E 43-359 [» ]
    2XQ4 X-ray 3.60 A/B/C/D/E 43-359 [» ]
    2XQ5 X-ray 3.50 A/B/C/D/E 43-359 [» ]
    2XQ6 X-ray 3.70 A/B/C/D/E 43-359 [» ]
    2XQ7 X-ray 3.40 A/B/C/D/E 43-359 [» ]
    2XQ8 X-ray 3.60 A/B/C/D/E 43-359 [» ]
    2XQ9 X-ray 3.20 A/B/C/D/E 43-359 [» ]
    2XQA X-ray 3.70 A/B/C/D/E 43-359 [» ]
    3EAM X-ray 2.90 A/B/C/D/E 44-359 [» ]
    3EHZ X-ray 3.10 A/B/C/D/E 50-359 [» ]
    3EI0 X-ray 3.50 A/B/C/D/E 50-359 [» ]
    3IGQ X-ray 2.30 A/B/C/D/E/F 44-235 [» ]
    3LSV X-ray 3.15 A/B/C/D/E 44-359 [» ]
    3P4W X-ray 3.20 A/B/C/D/E 44-359 [» ]
    3P50 X-ray 3.30 A/B/C/D/E 44-359 [» ]
    3TLS X-ray 3.20 A/B/C/D/E 44-359 [» ]
    3TLT X-ray 3.30 A/B/C/D/E 44-359 [» ]
    3TLU X-ray 2.85 A/B/C/D/E 44-359 [» ]
    3TLV X-ray 2.90 A/B/C/D/E 44-359 [» ]
    3TLW X-ray 2.60 A/B/C/D/E 44-359 [» ]
    3UU3 X-ray 3.15 A/B/C/D/E 44-359 [» ]
    3UU4 X-ray 3.05 A/B/C/D/E 44-359 [» ]
    3UU5 X-ray 2.90 A/B/C/D/E 44-359 [» ]
    3UU6 X-ray 2.98 A/B/C/D/E 44-359 [» ]
    3UU8 X-ray 3.25 A/B/C/D/E 44-359 [» ]
    3UUB X-ray 2.90 A/B/C/D/E/F/G/H/I/J 44-359 [» ]
    4F8H X-ray 2.99 A/B/C/D/E 43-359 [» ]
    4HFB X-ray 2.75 A/B/C/D/E 44-359 [» ]
    4HFC X-ray 3.05 A/B/C/D/E 44-359 [» ]
    4HFD X-ray 3.10 A/B/C/D/E 44-359 [» ]
    4HFE X-ray 2.80 A/B/C/D/E 44-359 [» ]
    4HFH X-ray 2.65 A/B/C/D/E 44-359 [» ]
    4HFI X-ray 2.40 A/B/C/D/E 44-359 [» ]
    4IL4 X-ray 3.30 A/B/C/D/E 44-359 [» ]
    4IL9 X-ray 2.83 A/B/C/D/E 44-358 [» ]
    4ILA X-ray 3.50 A/B/C/D/E 44-358 [» ]
    4ILB X-ray 3.15 A/B/C/D/E 44-358 [» ]
    4ILC X-ray 2.99 A/B/C/D/E 44-358 [» ]
    4IRE X-ray 3.19 A/B/C/D/E 43-359 [» ]
    4LMJ X-ray 3.44 A/B/C/D/E 44-359 [» ]
    4LMK X-ray 3.22 A/B/C/D/E 44-359 [» ]
    4LML X-ray 3.80 A/B/C/D/E 44-359 [» ]
    4NPP X-ray 3.35 A/B/C/D/E 44-359 [» ]
    4NPQ X-ray 4.35 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T 44-359 [» ]
    ProteinModelPortali Q7NDN8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59040N.
    MINTi MINT-8425450.
    STRINGi 251221.glr4197.

    Protein family/group databases

    TCDBi 1.A.9.8.1. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC92138 ; BAC92138 ; BAC92138 .
    GeneIDi 2602600.
    KEGGi gvi:glr4197.
    PATRICi 22047895. VBIGloVio86258_4229.

    Phylogenomic databases

    OMAi FTYEASF.
    OrthoDBi EOG6VF30W.
    PhylomeDBi Q7NDN8.

    Enzyme and pathway databases

    BioCyci GVIO251221:GH9A-4249-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q7NDN8.

    Family and domain databases

    Gene3Di 2.70.170.10. 1 hit.
    InterProi IPR006028. GABAA/Glycine_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR00253. GABAARECEPTR.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7421.
    2. "A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family."
      Bocquet N., Prado de Carvalho L., Cartaud J., Neyton J., Le Poupon C., Taly A., Grutter T., Changeux J.P., Corringer P.J.
      Nature 445:116-119(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS A PROTON-GATED ION CHANNEL, ION SELECTIVITY, ENZYME REGULATION, SUBUNIT.
      Strain: PCC 7421.
    3. "Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel."
      Weng Y., Yang L., Corringer P.J., Sonner J.M.
      Anesth. Analg. 110:59-63(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: MODULATION BY ANESTHETICS, ENZYME REGULATION.
      Strain: PCC 7421.
    4. "Anesthetic binding in a pentameric ligand-gated ion channel: GLIC."
      Chen Q., Cheng M.H., Xu Y., Tang P.
      Biophys. J. 99:1801-1809(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ANESTHETIC-BINDING, MUTAGENESIS STUDIES, FLUORESCENCE QUENCHING EXPERIMENTS.
      Strain: PCC 7421.
    5. "Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues."
      Corringer P.J., Baaden M., Bocquet N., Delarue M., Dufresne V., Nury H., Prevost M., Van Renterghem C.
      J. Physiol. (Lond.) 588:565-572(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    6. "Pore opening and closing of a pentameric ligand-gated ion channel."
      Zhu F., Hummer G.
      Proc. Natl. Acad. Sci. U.S.A. 107:19814-19819(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: GATING MECHANISM.
    7. "Ion selectivity mechanism in a bacterial pentameric ligand-gated ion channel."
      Fritsch S., Ivanov I., Wang H., Cheng X.
      Biophys. J. 100:390-398(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ION SELECTIVITY MECHANISM.
    8. "X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation."
      Bocquet N., Nury H., Baaden M., Le Poupon C., Changeux J.P., Delarue M., Corringer P.J.
      Nature 457:111-114(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 44-359, SUBUNIT.
      Strain: PCC 7421.
    9. "Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel."
      Hilf R.J., Dutzler R.
      Nature 457:115-118(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 43-359 OF WILD-TYPE AND MUTANT ALA-264, SUBUNIT, MUTAGENESIS OF GLU-264.
      Strain: PCC 7421.
    10. "Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel."
      Nury H., Bocquet N., Le Poupon C., Raynal B., Haouz A., Corringer P.J., Delarue M.
      J. Mol. Biol. 395:1114-1127(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 44-235, GATING MECHANISM.
      Strain: PCC 7421.
    11. "Structural basis of open channel block in a prokaryotic pentameric ligand-gated ion channel."
      Hilf R.J., Bertozzi C., Zimmermann I., Reiter A., Trauner D., Dutzler R.
      Nat. Struct. Mol. Biol. 17:1330-1336(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) OF 43-359 OF WILD-TYPE AND MUTANT ASP-264 IN COMPLEXES WITH POSITIVELY CHARGED INHIBITORS, ENZYME REGULATION, MUTAGENESIS OF GLU-264; THR-268 AND SER-272, MECHANISMS OF OPEN CHANNEL BLOCK.
      Strain: PCC 7421.
    12. "One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue."
      Nury H., Poitevin F., Van Renterghem C., Changeux J.P., Corringer P.J., Delarue M., Baaden M.
      Proc. Natl. Acad. Sci. U.S.A. 107:6275-6280(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.15 ANGSTROMS) OF 44-359 OF MUTANT PHE-279.
      Strain: PCC 7421.
    13. "X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel."
      Nury H., Van Renterghem C., Weng Y., Tran A., Baaden M., Dusfresne V., Changeux J.P., Sonner J.M., Delarue M., Corringer P.J.
      Nature 469:428-431(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.30 ANGSTROMS) OF 44-359 IN COMPLEXES WITH PROPOFOL AND DESFLURANE ANESTHETICS, MUTAGENESIS OF ILE-244; VAL-284 AND THR-297.
      Strain: PCC 7421.

    Entry informationi

    Entry nameiGLIC_GLOVI
    AccessioniPrimary (citable) accession number: Q7NDN8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 21, 2011
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The homologous nature of GLIC to eukaryotic nicotinic acetylcholine receptors and other eukaryotic pentameric ligand-gated ion channels, and its sensitivity to general anesthetics, define GLIC as a structural and functional model of signal transduction in the nervous system, also relevant for exploring the molecular basis of anesthetic action.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3