Q7ND78 (Q7ND78_GLOVI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

Name:	hemB EMBL BAC92299.1
Ordered Locus Names:	glr4358

Organism

Gloeobacter violaceus (strain PCC 7421)

Taxonomic identifier

251221 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Gloeobacteria › Gloeobacterales › Gloeobacter

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. PIRSR PIRSR001415-3 RuleBase RU000515
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-5 Zinc PIRSR PIRSR001415-3
Molecular function	Lyase RuleBase RU000515
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	198	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	251	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	119	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	121	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	129	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	236	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	208	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	220	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	277	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	316	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	Q7ND78 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: D98C8935A80A869B	FASTA	327	35,503
	10 20 30 40 50 60 MFPSVRPRRL RTTPTLRRMV RENHLHPEDL VSPIFVVPGS GFAREVSSMP GVFQLSVDKA 70 80 90 100 110 120 VEEAREVWDL GVPSVILFGI PEQKDAGATG AWHDHGIVQE ATTAIKAALP ELVVMADTCL 130 140 150 160 170 180 CEYTNHGHCG VIELSDTIGH VLNDPTLEIL GKTAVAQARA GADLIAPSGM MDGMVRAIRT 190 200 210 220 230 240 ALDEAGFTDT PILSYAAKYA SAYYGPFRDA AESTPQFGDR RTYQMDPANS REALKEIALD 250 260 270 280 290 300 IAEGADMLMV KPALAYLDIL HRVKAATHLP VAAYNVSGEY AMVKAAALNG WIDEERVVME 310 320 TLMSMKRAGA DLILTYHAKD AARWLGA

References

[1]

"Complete genome structure of Gloeobacter violaceus PCC 7421, a cyanobacterium that lacks thylakoids." Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T., Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M., Tabata S. DNA Res. 10:137-145(2003) [PubMed: 14621292] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7421.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000045 Genomic DNA. Translation: BAC92299.1.
RefSeq	NP_927304.1. NC_005125.1.
3D structure databases
HSSP	HSSP built from PDB template 1B4K based on UniProtKB Q59643.
ProteinModelPortal	Q7ND78.
SMR	Q7ND78. Positions 5-326.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2602761.
GenomeReviews	Gene locus glr4358 in contig BA000045_GR.
NMPDR	fig|251221.1.peg.4358.
PATRIC	22048211. VBIGloVio86258_4387.
Phylogenomic databases
HOGENOM	HBG285270.
OMA	HCGVVEN.
PhylomeDB	Q7ND78.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q7ND78_GLOVI

Accession

Primary (citable) accession number: Q7ND78

Entry history

Integrated into UniProtKB/TrEMBL:	December 15, 2003
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)