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Protein

Argininosuccinate synthase

Gene

argG

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei88CitrullineUniRule annotation1
Binding sitei118ATP; via amide nitrogenUniRule annotation1
Binding sitei120AspartateUniRule annotation1
Binding sitei124AspartateUniRule annotation1
Binding sitei124CitrullineUniRule annotation1
Binding sitei125AspartateUniRule annotation1
Binding sitei128CitrullineUniRule annotation1
Binding sitei176CitrullineUniRule annotation1
Binding sitei185CitrullineUniRule annotation1
Binding sitei261CitrullineUniRule annotation1
Binding sitei273CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 17ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGVIO251221:G1G3K-2969-MONOMER
UniPathwayiUPA00068; UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:glr2933
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacteraceaeGloeobacter
Proteomesi
  • UP000000557 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001485961 – 398Argininosuccinate synthaseAdd BLAST398

Proteomic databases

PRIDEiQ7NCP5

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi251221.gvip407

Structurei

3D structure databases

ProteinModelPortaliQ7NCP5
SMRiQ7NCP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
InParanoidiQ7NCP5
KOiK01940
OMAiGVGRIDM
OrthoDBiPOG091H01U0
PhylomeDBiQ7NCP5

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 2 hits
3.90.1260.10, 2 hits
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7NCP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAKKVVLAY SGGVDTSVCI PYLKHEWGVE QVVALAADLG QGEDLEAVRQ
60 70 80 90 100
KALASGADQA IVQDAREDFV YDYAFAALQA NALYEGRYPL ATALARPLIA
110 120 130 140 150
RILVKCAQAV GADAVAHGCT GKGNDQVRFD VSIGALDPKL KVLAPAREWG
160 170 180 190 200
MSREETIAYG ERYGIPAPVK KKSPYSIDFN LLGRSVECGV LEDPWAEPPE
210 220 230 240 250
EVYAMTKCVA DTPDQPTYIE LEFERGVPVA LNGASLGGVK LVGELNRLAG
260 270 280 290 300
ENGVGRIDMV ENRLVGIKSR EIYECPAGVV LVLAHQALEA LTLPREVTAY
310 320 330 340 350
KRGVEDTYAQ LVYNGLWYSP LRGALDGFID FTQQRASGVV RVRLHKGTAT
360 370 380 390
VVGRKSPYSL YDVELATYSE GDSFDHKAAE GFIYVWGLPT RIYAQVRK
Length:398
Mass (Da):43,362
Last modified:December 15, 2003 - v1
Checksum:iCFA0EFD4AB305BD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA Translation: BAC90874.1
RefSeqiNP_925879.1, NC_005125.1
WP_011142927.1, NC_005125.1

Genome annotation databases

EnsemblBacteriaiBAC90874; BAC90874; BAC90874
GeneIDi2601334
KEGGigvi:gvip407
PATRICifig|251221.4.peg.2962

Similar proteinsi

Entry informationi

Entry nameiASSY_GLOVI
AccessioniPrimary (citable) accession number: Q7NCP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: December 15, 2003
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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