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Q7NCP5

- ASSY_GLOVI

UniProt

Q7NCP5 - ASSY_GLOVI

Protein

Argininosuccinate synthase

Gene

argG

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei37 – 371ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei88 – 881CitrullineUniRule annotation
    Binding sitei118 – 1181ATP; via amide nitrogenUniRule annotation
    Binding sitei120 – 1201AspartateUniRule annotation
    Binding sitei124 – 1241AspartateUniRule annotation
    Binding sitei124 – 1241CitrullineUniRule annotation
    Binding sitei125 – 1251AspartateUniRule annotation
    Binding sitei128 – 1281CitrullineUniRule annotation
    Binding sitei176 – 1761CitrullineUniRule annotation
    Binding sitei185 – 1851CitrullineUniRule annotation
    Binding sitei261 – 2611CitrullineUniRule annotation
    Binding sitei273 – 2731CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 179ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciGVIO251221:GH9A-2969-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:glr2933
    OrganismiGloeobacter violaceus (strain PCC 7421)
    Taxonomic identifieri251221 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
    ProteomesiUP000000557: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 398398Argininosuccinate synthasePRO_0000148596Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi251221.gvip407.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7NCP5.
    SMRiQ7NCP5. Positions 5-398.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    KOiK01940.
    OMAiAPPEEAY.
    OrthoDBiEOG6K9QCV.
    PhylomeDBiQ7NCP5.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7NCP5-1 [UniParc]FASTAAdd to Basket

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    MRAKKVVLAY SGGVDTSVCI PYLKHEWGVE QVVALAADLG QGEDLEAVRQ    50
    KALASGADQA IVQDAREDFV YDYAFAALQA NALYEGRYPL ATALARPLIA 100
    RILVKCAQAV GADAVAHGCT GKGNDQVRFD VSIGALDPKL KVLAPAREWG 150
    MSREETIAYG ERYGIPAPVK KKSPYSIDFN LLGRSVECGV LEDPWAEPPE 200
    EVYAMTKCVA DTPDQPTYIE LEFERGVPVA LNGASLGGVK LVGELNRLAG 250
    ENGVGRIDMV ENRLVGIKSR EIYECPAGVV LVLAHQALEA LTLPREVTAY 300
    KRGVEDTYAQ LVYNGLWYSP LRGALDGFID FTQQRASGVV RVRLHKGTAT 350
    VVGRKSPYSL YDVELATYSE GDSFDHKAAE GFIYVWGLPT RIYAQVRK 398
    Length:398
    Mass (Da):43,362
    Last modified:December 15, 2003 - v1
    Checksum:iCFA0EFD4AB305BD5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC90874.1.
    RefSeqiNP_925879.1. NC_005125.1.
    WP_011142927.1. NC_005125.1.

    Genome annotation databases

    EnsemblBacteriaiBAC90874; BAC90874; BAC90874.
    GeneIDi2601334.
    KEGGigvi:gvip407.
    PATRICi22045337. VBIGloVio86258_2962.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000045 Genomic DNA. Translation: BAC90874.1 .
    RefSeqi NP_925879.1. NC_005125.1.
    WP_011142927.1. NC_005125.1.

    3D structure databases

    ProteinModelPortali Q7NCP5.
    SMRi Q7NCP5. Positions 5-398.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 251221.gvip407.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC90874 ; BAC90874 ; BAC90874 .
    GeneIDi 2601334.
    KEGGi gvi:gvip407.
    PATRICi 22045337. VBIGloVio86258_2962.

    Phylogenomic databases

    eggNOGi COG0137.
    KOi K01940.
    OMAi APPEEAY.
    OrthoDBi EOG6K9QCV.
    PhylomeDBi Q7NCP5.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci GVIO251221:GH9A-2969-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7421.

    Entry informationi

    Entry nameiASSY_GLOVI
    AccessioniPrimary (citable) accession number: Q7NCP5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3