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Q7NCG8

- SYW_GLOVI

UniProt

Q7NCG8 - SYW_GLOVI

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Protein

Tryptophan--tRNA ligase

Gene
trpS, glr3011
Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei203 – 2031ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGVIO251221:GH9A-3047-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:trpS
Ordered Locus Names:glr3011
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacter
ProteomesiUP000000557: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Tryptophan--tRNA ligaseUniRule annotationPRO_0000136633Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi251221.gvip414.

Structurei

3D structure databases

ProteinModelPortaliQ7NCG8.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi17 – 259"HIGH" regionUniRule annotation
Motifi200 – 2045"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0180.
KOiK01867.
OMAiIDPKKHI.
OrthoDBiEOG686NJQ.
PhylomeDBiQ7NCG8.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7NCG8-1 [UniParc]FASTAAdd to Basket

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MPDDSTAPKR ILSGAQPTGQ LHLGNYLGAV RNWVSEQRQY DSYFCVVDLH    50
ALTVPQEAAE LRAATRRTAA LYLACGIDPE RSTVFVQSHV SAHTELTWLF 100
NCLTPINWLE RMIQFKEKAI KLGEEVGIGL FDYPVLQAAD ILLYEPHLVP 150
VGEDQRQHLE LTRDIARRFN DRYGESLRVP EMLIRKEGAR VMSLQDGTSK 200
MSKSDPSDLS RLNLLDAPEK LRDKIKRAKS DAVMGLKFDP ARPECTNLLT 250
IYQLLSGESP EAVEARFADA GFGRFKPILA DLVIEYLRPI RERYDAIAGE 300
SGYLEGILRE GALRASKVAG LTLERIRDRM GLLPPF 336
Length:336
Mass (Da):37,795
Last modified:December 15, 2003 - v1
Checksum:i38D40A24C8F91ABB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC90952.1.
RefSeqiNP_925957.1. NC_005125.1.

Genome annotation databases

EnsemblBacteriaiBAC90952; BAC90952; BAC90952.
GeneIDi2601412.
KEGGigvi:gvip414.
PATRICi22045489. VBIGloVio86258_3038.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000045 Genomic DNA. Translation: BAC90952.1 .
RefSeqi NP_925957.1. NC_005125.1.

3D structure databases

ProteinModelPortali Q7NCG8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 251221.gvip414.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC90952 ; BAC90952 ; BAC90952 .
GeneIDi 2601412.
KEGGi gvi:gvip414.
PATRICi 22045489. VBIGloVio86258_3038.

Phylogenomic databases

eggNOGi COG0180.
KOi K01867.
OMAi IDPKKHI.
OrthoDBi EOG686NJQ.
PhylomeDBi Q7NCG8.

Enzyme and pathway databases

BioCyci GVIO251221:GH9A-3047-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_B. Trp_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7421.

Entry informationi

Entry nameiSYW_GLOVI
AccessioniPrimary (citable) accession number: Q7NCG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi