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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Gloeobacter violaceus (strain PCC 7421)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140L-tryptophanUniRule annotation1
Binding sitei191ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 18ATPUniRule annotation3
Nucleotide bindingi24 – 25ATPUniRule annotation2
Nucleotide bindingi152 – 154ATPUniRule annotation3
Nucleotide bindingi200 – 204ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGVIO251221:G1G3K-3047-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:glr3011
OrganismiGloeobacter violaceus (strain PCC 7421)
Taxonomic identifieri251221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaGloeobacteriaGloeobacteralesGloeobacteraceaeGloeobacter
Proteomesi
  • UP000000557 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366331 – 336Tryptophan--tRNA ligaseAdd BLAST336

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi251221.gvip414

Structurei

3D structure databases

ProteinModelPortaliQ7NCG8
SMRiQ7NCG8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi17 – 25"HIGH" regionUniRule annotation9
Motifi200 – 204"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
InParanoidiQ7NCG8
KOiK01867
OMAiQRMTQFK
OrthoDBiPOG091H00I9
PhylomeDBiQ7NCG8

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q7NCG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDDSTAPKR ILSGAQPTGQ LHLGNYLGAV RNWVSEQRQY DSYFCVVDLH
60 70 80 90 100
ALTVPQEAAE LRAATRRTAA LYLACGIDPE RSTVFVQSHV SAHTELTWLF
110 120 130 140 150
NCLTPINWLE RMIQFKEKAI KLGEEVGIGL FDYPVLQAAD ILLYEPHLVP
160 170 180 190 200
VGEDQRQHLE LTRDIARRFN DRYGESLRVP EMLIRKEGAR VMSLQDGTSK
210 220 230 240 250
MSKSDPSDLS RLNLLDAPEK LRDKIKRAKS DAVMGLKFDP ARPECTNLLT
260 270 280 290 300
IYQLLSGESP EAVEARFADA GFGRFKPILA DLVIEYLRPI RERYDAIAGE
310 320 330
SGYLEGILRE GALRASKVAG LTLERIRDRM GLLPPF
Length:336
Mass (Da):37,795
Last modified:December 15, 2003 - v1
Checksum:i38D40A24C8F91ABB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000045 Genomic DNA Translation: BAC90952.1
RefSeqiNP_925957.1, NC_005125.1
WP_011143004.1, NC_005125.1

Genome annotation databases

EnsemblBacteriaiBAC90952; BAC90952; BAC90952
GeneIDi2601412
KEGGigvi:gvip414
PATRICifig|251221.4.peg.3038

Similar proteinsi

Entry informationi

Entry nameiSYW_GLOVI
AccessioniPrimary (citable) accession number: Q7NCG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health