Q7NBZ4 (IF2_MYCGA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Translation initiation factor IF-2

Gene names

Name:	infB
Ordered Locus Names:	MYCGA1150
ORF Names:	MGA_0821

Organism

Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2)) [Complete proteome] [HAMAP]

Taxonomic identifier

710127 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma gallisepticum › Mycoplasma gallisepticum str. R

Protein attributes

Sequence length	615 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity. HAMAP-Rule MF_00100
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the IF-2 family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Initiation factor
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	GTP catabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: HAMAP translation initiation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 615	615	Translation initiation factor IF-2 HAMAP-Rule MF_00100		PRO_0000137220
Regions
	Nucleotide binding	127 – 134	8	GTP By similarity
	Nucleotide binding	173 – 177	5	GTP By similarity
	Nucleotide binding	227 – 230	4	GTP By similarity
	Region	121 – 269	149	G-domain HAMAP-Rule MF_00100

Sequences

	Sequence		Length	Mass (Da)
	Q7NBZ4 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 422C80CBB42E5974	FASTA	615	68,086
	10 20 30 40 50 60 MNKKPTRNKK PVDQRSKINI KSYLKEVQVG VKDGVFIYTD PLSIDQFAKK VNQPVAKIIK 70 80 90 100 110 120 HFFSKGINTI NLNTILSLEQ IGELCLDLGL DFKIEKSVTS ENLLDNIEFK DKKEDLVKRP 130 140 150 160 170 180 PIVTVMGHVD HGKTSLLDAI RSTNVTSNEA GGITQHIGAY QVKKNDELIT FIDTPGHEAF 190 200 210 220 230 240 TEMRARGANL TDIVVLVVAG DDGIKPQTEE AIDHAKNANV PIIVFVNKMD KSGANFDRVI 250 260 270 280 290 300 QQISKYDLSP EEYGGDTIFV QGSAIKKEGI NELLDAILTL AEINEYKANP NADPYGIVIE 310 320 330 340 350 360 SKLEPGLGPQ ATVIIKRGTL KVGDYICIGA AYGKVRIMQD ENGNNLTEAT PSRPVKISGL 370 380 390 400 410 420 DAIPQAGEKF LGLATEKEVK ELSDSYKLKQ QKQKHLSLQE SHEKRTRINT NGIKCVDLII 430 440 450 460 470 480 KSDVQGSLEA IKYAISNINI EGVTTNIIRA STGVISETDI KLAQASNSTV ISFNLGVSKQ 490 500 510 520 530 540 IRDLANSDNV QILSYEIIYK MVEDLEKIMK GELDPVYEES VIGQAVVRVL WKHSKIGTIA 550 560 570 580 590 600 GSYVTSGKVV KNALCRVLRD DVIIYKSKIA SLKSKTTFVD KVEHNKECGI VVENYNDIKE 610 DDIIEVYEIV KKRVY

References

[1]

"The complete genome sequence of the avian pathogen Mycoplasma gallisepticum strain R(low)." Papazisi L., Gorton T.S., Kutish G., Markham P.F., Browning G.F., Nguyen D.K., Swartzell S., Madan A., Mahairas G., Geary S.J. Microbiology 149:2307-2316(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: R(low / passage 15 / clone 2).

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015450 Genomic DNA. Translation: AAP56465.1.
RefSeq	NP_852897.1. NC_004829.2.
3D structure databases
ProteinModelPortal	Q7NBZ4.
ModBase	Search...
Protein-protein interaction databases
STRING	233150.MGA_0821.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAP56465; AAP56465; MGA_0821.
GeneID	1090164.
KEGG	mga:MGA_0821.
PATRIC	20007919. VBIMycGal115357_0125.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0532.
HOGENOM	HOG000076906.
KO	K02519.
OMA	HIGAFTV.
ProtClustDB	PRK05306.
Family and domain databases
Gene3D	3.40.50.10050. 1 hit.
HAMAP	MF_00100_B. IF-2_B.
InterPro	IPR000795. EF_GTP-bd_dom. IPR006847. IF2_N. IPR005225. Small_GTP-bd_dom. IPR000178. TF_IF2_bacterial-like. IPR015760. TIF_IF2. IPR023115. TIF_IF2_dom3. IPR004161. Transl_elong_EFTu/EF1A_2. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
PANTHER	PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfam	PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. PF11987. IF-2. 1 hit. PF04760. IF2_N. 1 hit. [Graphical view]
SUPFAM	SSF52156. TIF_IF2_dom3. 1 hit. SSF50447. Translat_factor. 2 hits.
TIGRFAMs	TIGR00487. IF-2. 1 hit. TIGR00231. small_GTP. 1 hit.
PROSITE	PS01176. IF2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IF2_MYCGA

Accession

Primary (citable) accession number: Q7NBZ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	December 15, 2003
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program