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Q7NBG2

- TRMB_MYCGA

UniProt

Q7NBG2 - TRMB_MYCGA

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, MYCGA3170, MGA_1194
Organism
Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381S-adenosyl-L-methionine By similarity
Binding sitei63 – 631S-adenosyl-L-methionine By similarity
Binding sitei91 – 911S-adenosyl-L-methionine By similarity
Active sitei113 – 1131 By similarity
Binding sitei113 – 1131S-adenosyl-L-methionine By similarity
Binding sitei117 – 1171Substrate By similarity
Binding sitei149 – 1491Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMGAL710127:GC09-372-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:MYCGA3170
ORF Names:MGA_1194
OrganismiMycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Taxonomic identifieri710127 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000001418: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_0000171350Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233150.MGA_1194.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni192 – 1954Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000251689.
KOiK03439.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7NBG2-1 [UniParc]FASTAAdd to Basket

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MRIRNIRDAH LKINKAKNII GVDNLKTKLD PKKFNALEIG SGKGGFIYQK    50
AITNPGINYF GIEKNATVIL KMINKSELLE QLTNLFIVHD DFALIDHEFP 100
NACFDQIYLN FSDPWPKKRH AKKRLVDLAF LNKYQRILKA DGIIEFKTDN 150
DQLFNYAIEM INSLEQIKII AYTNDLHSLD SSDALLKNNV ITEYEQRFIN 200
LKKNINKIVF KFI 213
Length:213
Mass (Da):24,748
Last modified:June 15, 2010 - v2
Checksum:i8D1439AC1CF0349D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015450 Genomic DNA. Translation: AAP56667.2.
RefSeqiNP_853099.2. NC_004829.2.

Genome annotation databases

EnsemblBacteriaiAAP56667; AAP56667; MGA_1194.
GeneIDi1089649.
KEGGimga:MGA_1194.
PATRICi20008431. VBIMycGal115357_0351.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015450 Genomic DNA. Translation: AAP56667.2 .
RefSeqi NP_853099.2. NC_004829.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233150.MGA_1194.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP56667 ; AAP56667 ; MGA_1194 .
GeneIDi 1089649.
KEGGi mga:MGA_1194.
PATRICi 20008431. VBIMycGal115357_0351.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000251689.
KOi K03439.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci MGAL710127:GC09-372-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the avian pathogen Mycoplasma gallisepticum strain R(low)."
    Papazisi L., Gorton T.S., Kutish G., Markham P.F., Browning G.F., Nguyen D.K., Swartzell S., Madan A., Mahairas G., Geary S.J.
    Microbiology 149:2307-2316(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R(low / passage 15 / clone 2).

Entry informationi

Entry nameiTRMB_MYCGA
AccessioniPrimary (citable) accession number: Q7NBG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 15, 2010
Last modified: June 11, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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