ID   UVRC_MYCGA              Reviewed;         592 AA.
AC   Q7NBC4;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 2.
DT   27-MAR-2024, entry version 110.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203};
GN   OrderedLocusNames=MYCGA3550; ORFNames=MGA_1269;
OS   Mycoplasmoides gallisepticum (strain R(low / passage 15 / clone 2))
OS   (Mycoplasma gallisepticum).
OC   Bacteria; Mycoplasmatota; Mycoplasmoidales; Mycoplasmoidaceae;
OC   Mycoplasmoides.
OX   NCBI_TaxID=710127;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R(low / passage 15 / clone 2);
RX   PubMed=12949158; DOI=10.1099/mic.0.26427-0;
RA   Papazisi L., Gorton T.S., Kutish G., Markham P.F., Browning G.F.,
RA   Nguyen D.K., Swartzell S., Madan A., Mahairas G., Geary S.J.;
RT   "The complete genome sequence of the avian pathogen Mycoplasma
RT   gallisepticum strain R(low).";
RL   Microbiology 149:2307-2316(2003).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAP56705.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE015450; AAP56705.2; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q7NBC4; -.
DR   SMR; Q7NBC4; -.
DR   KEGG; mga:MGA_1269; -.
DR   HOGENOM; CLU_014841_3_2_14; -.
DR   Proteomes; UP000001418; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR   Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   NCBIfam; TIGR00194; uvrC; 1.
DR   PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR   PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR   SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..592
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264915"
FT   DOMAIN          14..91
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          197..232
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   592 AA;  69238 MW;  B2280A0F69033DCC CRC64;
     MNFNLKQKLD LAPKKPGCYL WKNHLNEIIY IGKAKNIYKR VHQYFNGPKD LKTSKLVNEI
     FYVEFIEVNN ENEALLLEAN LIKKHKPRYN ILLKDNNGYP YILMTKEKYP RLIYTRNFDP
     KKGKHYGPFA SSEMKAYDLY NLLLKLFPLK NCFNKKGRKC EFYDLNLCMK ACTHEVSEAD
     YEVMKKKIDY FFHNGADQVL KDLKEKESIA SEKFDFEQAK KYLDLQKAIN LIFDKQIINL
     YSAKERIDVL AYQIKENVIC IVLFSYVSSQ LVSKNTICDF YYGEEQEVIT SYLSQYYKDN
     IKPKILYASL DQANATLLKD SLGIEIINPT SGKMNEIMSL ALQNVTNELS QKYDSLVKKE
     QRINLALDQL KKLIKVDKLN HLEVYDNSNL FNTDKVSAMI VFENNQFNKK KYRKYKIKDQ
     QALGDYHYMY EVIYRRLYQA LKNNFVDLPD LIILDGGKHQ VLAAKKAIVD LQIDKKINLI
     GLAKNNKHQT DKIVTFDLDE ISLDKSSALY FFLANLQEEV HKFAISFFRK TKAKSLYDSI
     LDQIKGLGKK RKQQLIEHFK TIDEIKKASI ASLSQVLPIE IAKKLKQKLD QS
//