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Protein

UvrABC system protein C

Gene

uvrC

Organism
Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Enzyme and pathway databases

BioCyciMGAL710127:GC09-416-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:MYCGA3550
ORF Names:MGA_1269
OrganismiMycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Taxonomic identifieri710127 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000001418 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 592592UvrABC system protein CPRO_0000264915Add
BLAST

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi233150.MGA_1269.

Structurei

3D structure databases

ProteinModelPortaliQ7NBC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 9178GIY-YIGUniRule annotationAdd
BLAST
Domaini197 – 23236UVRUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation
Contains 1 GIY-YIG domain.UniRule annotation
Contains 1 UVR domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0322.
HOGENOMiHOG000279960.
KOiK03703.
OMAiRCPGVCQ.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
HAMAPiMF_00203. UvrC.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00278. HhH1. 1 hit.
[Graphical view]
SUPFAMiSSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7NBC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFNLKQKLD LAPKKPGCYL WKNHLNEIIY IGKAKNIYKR VHQYFNGPKD
60 70 80 90 100
LKTSKLVNEI FYVEFIEVNN ENEALLLEAN LIKKHKPRYN ILLKDNNGYP
110 120 130 140 150
YILMTKEKYP RLIYTRNFDP KKGKHYGPFA SSEMKAYDLY NLLLKLFPLK
160 170 180 190 200
NCFNKKGRKC EFYDLNLCMK ACTHEVSEAD YEVMKKKIDY FFHNGADQVL
210 220 230 240 250
KDLKEKESIA SEKFDFEQAK KYLDLQKAIN LIFDKQIINL YSAKERIDVL
260 270 280 290 300
AYQIKENVIC IVLFSYVSSQ LVSKNTICDF YYGEEQEVIT SYLSQYYKDN
310 320 330 340 350
IKPKILYASL DQANATLLKD SLGIEIINPT SGKMNEIMSL ALQNVTNELS
360 370 380 390 400
QKYDSLVKKE QRINLALDQL KKLIKVDKLN HLEVYDNSNL FNTDKVSAMI
410 420 430 440 450
VFENNQFNKK KYRKYKIKDQ QALGDYHYMY EVIYRRLYQA LKNNFVDLPD
460 470 480 490 500
LIILDGGKHQ VLAAKKAIVD LQIDKKINLI GLAKNNKHQT DKIVTFDLDE
510 520 530 540 550
ISLDKSSALY FFLANLQEEV HKFAISFFRK TKAKSLYDSI LDQIKGLGKK
560 570 580 590
RKQQLIEHFK TIDEIKKASI ASLSQVLPIE IAKKLKQKLD QS
Length:592
Mass (Da):69,238
Last modified:December 12, 2006 - v2
Checksum:iB2280A0F69033DCC
GO

Sequence cautioni

The sequence AAP56705.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015450 Genomic DNA. Translation: AAP56705.2. Different initiation.
RefSeqiNP_853137.3. NC_004829.2.
WP_011113601.1. NC_004829.2.

Genome annotation databases

EnsemblBacteriaiAAP56705; AAP56705; MGA_1269.
KEGGimga:MGA_1269.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015450 Genomic DNA. Translation: AAP56705.2. Different initiation.
RefSeqiNP_853137.3. NC_004829.2.
WP_011113601.1. NC_004829.2.

3D structure databases

ProteinModelPortaliQ7NBC4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi233150.MGA_1269.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP56705; AAP56705; MGA_1269.
KEGGimga:MGA_1269.

Phylogenomic databases

eggNOGiCOG0322.
HOGENOMiHOG000279960.
KOiK03703.
OMAiRCPGVCQ.

Enzyme and pathway databases

BioCyciMGAL710127:GC09-416-MONOMER.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
HAMAPiMF_00203. UvrC.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00278. HhH1. 1 hit.
[Graphical view]
SUPFAMiSSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of the avian pathogen Mycoplasma gallisepticum strain R(low)."
    Papazisi L., Gorton T.S., Kutish G., Markham P.F., Browning G.F., Nguyen D.K., Swartzell S., Madan A., Mahairas G., Geary S.J.
    Microbiology 149:2307-2316(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R(low / passage 15 / clone 2).

Entry informationi

Entry nameiUVRC_MYCGA
AccessioniPrimary (citable) accession number: Q7NBC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: May 27, 2015
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.