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Q7NBC4 (UVRC_MYCGA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UvrABC system protein C

Short name=Protein UvrC
Alternative name(s):
Excinuclease ABC subunit C
Gene names
Name:uvrC
Ordered Locus Names:MYCGA3550
ORF Names:MGA_1269
OrganismMycoplasma gallisepticum (strain R(low / passage 15 / clone 2)) [Complete proteome] [HAMAP]
Taxonomic identifier710127 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length592 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision By similarity. HAMAP-Rule MF_00203

Subunit structure

Interacts with UvrB in an incision complex By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00203.

Sequence similarities

Belongs to the UvrC family.

Contains 1 GIY-YIG domain.

Contains 1 UVR domain.

Sequence caution

The sequence AAP56705.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processDNA damage
DNA excision
DNA repair
SOS response
   Cellular componentCytoplasm
   Molecular functionExcision nuclease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processSOS response

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleotide-excision repair

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

excinuclease repair complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

excinuclease ABC activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 592592UvrABC system protein C HAMAP-Rule MF_00203
PRO_0000264915

Regions

Domain14 – 9178GIY-YIG
Domain197 – 23236UVR

Sequences

Sequence LengthMass (Da)Tools
Q7NBC4 [UniParc].

Last modified December 12, 2006. Version 2.
Checksum: B2280A0F69033DCC

FASTA59269,238
        10         20         30         40         50         60 
MNFNLKQKLD LAPKKPGCYL WKNHLNEIIY IGKAKNIYKR VHQYFNGPKD LKTSKLVNEI 

        70         80         90        100        110        120 
FYVEFIEVNN ENEALLLEAN LIKKHKPRYN ILLKDNNGYP YILMTKEKYP RLIYTRNFDP 

       130        140        150        160        170        180 
KKGKHYGPFA SSEMKAYDLY NLLLKLFPLK NCFNKKGRKC EFYDLNLCMK ACTHEVSEAD 

       190        200        210        220        230        240 
YEVMKKKIDY FFHNGADQVL KDLKEKESIA SEKFDFEQAK KYLDLQKAIN LIFDKQIINL 

       250        260        270        280        290        300 
YSAKERIDVL AYQIKENVIC IVLFSYVSSQ LVSKNTICDF YYGEEQEVIT SYLSQYYKDN 

       310        320        330        340        350        360 
IKPKILYASL DQANATLLKD SLGIEIINPT SGKMNEIMSL ALQNVTNELS QKYDSLVKKE 

       370        380        390        400        410        420 
QRINLALDQL KKLIKVDKLN HLEVYDNSNL FNTDKVSAMI VFENNQFNKK KYRKYKIKDQ 

       430        440        450        460        470        480 
QALGDYHYMY EVIYRRLYQA LKNNFVDLPD LIILDGGKHQ VLAAKKAIVD LQIDKKINLI 

       490        500        510        520        530        540 
GLAKNNKHQT DKIVTFDLDE ISLDKSSALY FFLANLQEEV HKFAISFFRK TKAKSLYDSI 

       550        560        570        580        590 
LDQIKGLGKK RKQQLIEHFK TIDEIKKASI ASLSQVLPIE IAKKLKQKLD QS 

« Hide

References

[1]"The complete genome sequence of the avian pathogen Mycoplasma gallisepticum strain R(low)."
Papazisi L., Gorton T.S., Kutish G., Markham P.F., Browning G.F., Nguyen D.K., Swartzell S., Madan A., Mahairas G., Geary S.J.
Microbiology 149:2307-2316(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: R(low / passage 15 / clone 2).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015450 Genomic DNA. Translation: AAP56705.2. Different initiation.
RefSeqNP_853137.3. NC_004829.2.

3D structure databases

ProteinModelPortalQ7NBC4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233150.MGA_1269.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP56705; AAP56705; MGA_1269.
GeneID1089683.
KEGGmga:MGA_1269.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0322.
HOGENOMHOG000279960.
KOK03703.
OMAQTIASCV.

Enzyme and pathway databases

BioCycMGAL710127:GC09-416-MONOMER.

Family and domain databases

Gene3D3.40.1440.10. 1 hit.
HAMAPMF_00203. UvrC.
InterProIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamPF01541. GIY-YIG. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTSM00465. GIYc. 1 hit.
SM00278. HhH1. 1 hit.
[Graphical view]
SUPFAMSSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsTIGR00194. uvrC. 1 hit.
PROSITEPS50164. GIY_YIG. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUVRC_MYCGA
AccessionPrimary (citable) accession number: Q7NBC4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: May 14, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families