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Q7NB47

- SYL_MYCGA

UniProt

Q7NB47 - SYL_MYCGA

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei586 – 5861ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMGAL710127:GC09-501-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:MYCGA4330
    ORF Names:MGA_0087
    OrganismiMycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
    Taxonomic identifieri710127 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000001418: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 805805Leucine--tRNA ligasePRO_0000152044Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi233150.MGA_0087.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7NB47.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi39 – 5012"HIGH" regionAdd
    BLAST
    Motifi583 – 5875"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7NB47-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYNHNLIEKK WAKIWNDQKI YSFQIDKNKP KYYILDMFPY PSGKGLHVGH    50
    VKAYMATDVI SRWKNALGFN VLHPIGWDAF GLPAEQYAIQ TNNHPAKFTQ 100
    ENINNFRTQL KRLGFNYDYR LEVDTTNKNY FKWTQWIFKK LYEHDLAYQA 150
    DIEVNWCEQL GTVLANEEVL TDENGNKISE RGSYPVIKKK MRQWVLKITA 200
    FADQLIDDLE NLNWPNSIKA MQVNWINKSV GASIKFEIDQ LDNQTIEVFS 250
    SRADTLFGAS FLALSFDHPL VKQKLITDKN NAIEQFIKDN SIDQRVRYQG 300
    INTNYFAIHP ITKKKIPIYL ADYILSDYGT GAVMGVPAHD ERDYQFAKQY 350
    DLEIIPVIKA DQYPYLLDGE HINSEFNNGL NNEQAIQKTI AYLREHNLGD 400
    QKINYKLRDW IFSRQRYWGE PFPVLFDEED NIYLLKDSEL PVELPQLSDF 450
    SPNKDGLPPL ANADDQWLHP IIDQKKYRRE INTMPQWAGS CWYYLAYLLK 500
    LTDLNQADGD QNYLALNSEK AKELFDHFMP VDLYVGGQEH AVLHLLYARF 550
    WYKFLHHIKI VSSTEPFSQL INQGMILGED NTKMSKSKGN IINPDDLVLS 600
    HGADTIRTYV MFMGPLNASL AWNSNALNGT RKFLERVYNL FDRVEINDSI 650
    NQNLNYDYHN FLKKINKHLE NFEFNLVVSE MMIFINACYK QTQVNKEMIT 700
    NFLIVLSFFA PYLAEELNSK LNNPTLLYKM RLAQWDEAYL VKNTTTISCS 750
    INGKFKLVHE FDLDSDEQEV ANYFLNQDLI KRNLENKKLV KTIFVKNKVI 800
    NFIIK 805
    Length:805
    Mass (Da):94,221
    Last modified:December 15, 2003 - v1
    Checksum:iA959DB38B8888710
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015450 Genomic DNA. Translation: AAP56783.1.
    RefSeqiNP_853215.1. NC_004829.2.
    WP_011113683.1. NC_004829.2.

    Genome annotation databases

    EnsemblBacteriaiAAP56783; AAP56783; MGA_0087.
    GeneIDi1089816.
    KEGGimga:MGA_0087.
    PATRICi20008713. VBIMycGal115357_0491.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015450 Genomic DNA. Translation: AAP56783.1 .
    RefSeqi NP_853215.1. NC_004829.2.
    WP_011113683.1. NC_004829.2.

    3D structure databases

    ProteinModelPortali Q7NB47.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233150.MGA_0087.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP56783 ; AAP56783 ; MGA_0087 .
    GeneIDi 1089816.
    KEGGi mga:MGA_0087.
    PATRICi 20008713. VBIMycGal115357_0491.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci MGAL710127:GC09-501-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the avian pathogen Mycoplasma gallisepticum strain R(low)."
      Papazisi L., Gorton T.S., Kutish G., Markham P.F., Browning G.F., Nguyen D.K., Swartzell S., Madan A., Mahairas G., Geary S.J.
      Microbiology 149:2307-2316(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: R(low / passage 15 / clone 2).

    Entry informationi

    Entry nameiSYL_MYCGA
    AccessioniPrimary (citable) accession number: Q7NB47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3