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Q7NB47

- SYL_MYCGA

UniProt

Q7NB47 - SYL_MYCGA

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Protein
Leucine--tRNA ligase
Gene
leuS, MYCGA4330, MGA_0087
Organism
Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei586 – 5861ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMGAL710127:GC09-501-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:MYCGA4330
ORF Names:MGA_0087
OrganismiMycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Taxonomic identifieri710127 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000001418: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 805805Leucine--tRNA ligaseUniRule annotation
PRO_0000152044Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233150.MGA_0087.

Structurei

3D structure databases

ProteinModelPortaliQ7NB47.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi39 – 5012"HIGH" regionUniRule annotation
Add
BLAST
Motifi583 – 5875"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7NB47-1 [UniParc]FASTAAdd to Basket

« Hide

MYNHNLIEKK WAKIWNDQKI YSFQIDKNKP KYYILDMFPY PSGKGLHVGH    50
VKAYMATDVI SRWKNALGFN VLHPIGWDAF GLPAEQYAIQ TNNHPAKFTQ 100
ENINNFRTQL KRLGFNYDYR LEVDTTNKNY FKWTQWIFKK LYEHDLAYQA 150
DIEVNWCEQL GTVLANEEVL TDENGNKISE RGSYPVIKKK MRQWVLKITA 200
FADQLIDDLE NLNWPNSIKA MQVNWINKSV GASIKFEIDQ LDNQTIEVFS 250
SRADTLFGAS FLALSFDHPL VKQKLITDKN NAIEQFIKDN SIDQRVRYQG 300
INTNYFAIHP ITKKKIPIYL ADYILSDYGT GAVMGVPAHD ERDYQFAKQY 350
DLEIIPVIKA DQYPYLLDGE HINSEFNNGL NNEQAIQKTI AYLREHNLGD 400
QKINYKLRDW IFSRQRYWGE PFPVLFDEED NIYLLKDSEL PVELPQLSDF 450
SPNKDGLPPL ANADDQWLHP IIDQKKYRRE INTMPQWAGS CWYYLAYLLK 500
LTDLNQADGD QNYLALNSEK AKELFDHFMP VDLYVGGQEH AVLHLLYARF 550
WYKFLHHIKI VSSTEPFSQL INQGMILGED NTKMSKSKGN IINPDDLVLS 600
HGADTIRTYV MFMGPLNASL AWNSNALNGT RKFLERVYNL FDRVEINDSI 650
NQNLNYDYHN FLKKINKHLE NFEFNLVVSE MMIFINACYK QTQVNKEMIT 700
NFLIVLSFFA PYLAEELNSK LNNPTLLYKM RLAQWDEAYL VKNTTTISCS 750
INGKFKLVHE FDLDSDEQEV ANYFLNQDLI KRNLENKKLV KTIFVKNKVI 800
NFIIK 805
Length:805
Mass (Da):94,221
Last modified:December 15, 2003 - v1
Checksum:iA959DB38B8888710
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015450 Genomic DNA. Translation: AAP56783.1.
RefSeqiNP_853215.1. NC_004829.2.
WP_011113683.1. NC_004829.2.

Genome annotation databases

EnsemblBacteriaiAAP56783; AAP56783; MGA_0087.
GeneIDi1089816.
KEGGimga:MGA_0087.
PATRICi20008713. VBIMycGal115357_0491.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015450 Genomic DNA. Translation: AAP56783.1 .
RefSeqi NP_853215.1. NC_004829.2.
WP_011113683.1. NC_004829.2.

3D structure databases

ProteinModelPortali Q7NB47.
ModBasei Search...

Protein-protein interaction databases

STRINGi 233150.MGA_0087.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP56783 ; AAP56783 ; MGA_0087 .
GeneIDi 1089816.
KEGGi mga:MGA_0087.
PATRICi 20008713. VBIMycGal115357_0491.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci MGAL710127:GC09-501-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the avian pathogen Mycoplasma gallisepticum strain R(low)."
    Papazisi L., Gorton T.S., Kutish G., Markham P.F., Browning G.F., Nguyen D.K., Swartzell S., Madan A., Mahairas G., Geary S.J.
    Microbiology 149:2307-2316(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R(low / passage 15 / clone 2).

Entry informationi

Entry nameiSYL_MYCGA
AccessioniPrimary (citable) accession number: Q7NB47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: December 15, 2003
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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