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Q7NB47

- SYL_MYCGA

UniProt

Q7NB47 - SYL_MYCGA

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei586 – 5861ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMGAL710127:GC09-501-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:MYCGA4330
ORF Names:MGA_0087
OrganismiMycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Taxonomic identifieri710127 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000001418: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 805805Leucine--tRNA ligasePRO_0000152044Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233150.MGA_0087.

Structurei

3D structure databases

ProteinModelPortaliQ7NB47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi39 – 5012"HIGH" regionAdd
BLAST
Motifi583 – 5875"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7NB47-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYNHNLIEKK WAKIWNDQKI YSFQIDKNKP KYYILDMFPY PSGKGLHVGH
60 70 80 90 100
VKAYMATDVI SRWKNALGFN VLHPIGWDAF GLPAEQYAIQ TNNHPAKFTQ
110 120 130 140 150
ENINNFRTQL KRLGFNYDYR LEVDTTNKNY FKWTQWIFKK LYEHDLAYQA
160 170 180 190 200
DIEVNWCEQL GTVLANEEVL TDENGNKISE RGSYPVIKKK MRQWVLKITA
210 220 230 240 250
FADQLIDDLE NLNWPNSIKA MQVNWINKSV GASIKFEIDQ LDNQTIEVFS
260 270 280 290 300
SRADTLFGAS FLALSFDHPL VKQKLITDKN NAIEQFIKDN SIDQRVRYQG
310 320 330 340 350
INTNYFAIHP ITKKKIPIYL ADYILSDYGT GAVMGVPAHD ERDYQFAKQY
360 370 380 390 400
DLEIIPVIKA DQYPYLLDGE HINSEFNNGL NNEQAIQKTI AYLREHNLGD
410 420 430 440 450
QKINYKLRDW IFSRQRYWGE PFPVLFDEED NIYLLKDSEL PVELPQLSDF
460 470 480 490 500
SPNKDGLPPL ANADDQWLHP IIDQKKYRRE INTMPQWAGS CWYYLAYLLK
510 520 530 540 550
LTDLNQADGD QNYLALNSEK AKELFDHFMP VDLYVGGQEH AVLHLLYARF
560 570 580 590 600
WYKFLHHIKI VSSTEPFSQL INQGMILGED NTKMSKSKGN IINPDDLVLS
610 620 630 640 650
HGADTIRTYV MFMGPLNASL AWNSNALNGT RKFLERVYNL FDRVEINDSI
660 670 680 690 700
NQNLNYDYHN FLKKINKHLE NFEFNLVVSE MMIFINACYK QTQVNKEMIT
710 720 730 740 750
NFLIVLSFFA PYLAEELNSK LNNPTLLYKM RLAQWDEAYL VKNTTTISCS
760 770 780 790 800
INGKFKLVHE FDLDSDEQEV ANYFLNQDLI KRNLENKKLV KTIFVKNKVI

NFIIK
Length:805
Mass (Da):94,221
Last modified:December 15, 2003 - v1
Checksum:iA959DB38B8888710
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015450 Genomic DNA. Translation: AAP56783.1.
RefSeqiNP_853215.1. NC_004829.2.

Genome annotation databases

EnsemblBacteriaiAAP56783; AAP56783; MGA_0087.
GeneIDi1089816.
KEGGimga:MGA_0087.
PATRICi20008713. VBIMycGal115357_0491.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015450 Genomic DNA. Translation: AAP56783.1 .
RefSeqi NP_853215.1. NC_004829.2.

3D structure databases

ProteinModelPortali Q7NB47.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233150.MGA_0087.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP56783 ; AAP56783 ; MGA_0087 .
GeneIDi 1089816.
KEGGi mga:MGA_0087.
PATRICi 20008713. VBIMycGal115357_0491.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci MGAL710127:GC09-501-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the avian pathogen Mycoplasma gallisepticum strain R(low)."
    Papazisi L., Gorton T.S., Kutish G., Markham P.F., Browning G.F., Nguyen D.K., Swartzell S., Madan A., Mahairas G., Geary S.J.
    Microbiology 149:2307-2316(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R(low / passage 15 / clone 2).

Entry informationi

Entry nameiSYL_MYCGA
AccessioniPrimary (citable) accession number: Q7NB47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: December 15, 2003
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3