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Q7NAU0 (NADK_MYCGA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:MYCGA5450
ORF Names:MGA_0291
OrganismMycoplasma gallisepticum (strain R(low / passage 15 / clone 2)) [Complete proteome] [HAMAP]
Taxonomic identifier710127 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274NAD kinase HAMAP-Rule MF_00361
PRO_0000229656

Regions

Nucleotide binding60 – 612NAD By similarity
Nucleotide binding127 – 1282NAD By similarity

Sites

Active site601Proton acceptor By similarity
Binding site651NAD By similarity
Binding site1521NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7NAU0 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 2C5C05BEA96AFFCF

FASTA27430,923
        10         20         30         40         50         60 
MIMKVHQVQE KKMNKTYYLI SSLAPKSESL KPLIKKELNK KLVEVDDPTV ADYLFINGGD 

        70         80         90        100        110        120 
GTFIKNAIKY DRAGLKIIGI NGGSLGFYTT FNETNIDQIA NNLDQLKYTQ LDFIRLQIDD 

       130        140        150        160        170        180 
QIHHALNEFN INSTTAYGYD IFIDNEFYQK FRGTGLLIST TTGSTGINKS ANGAILFPRI 

       190        200        210        220        230        240 
KAIQMVELYP LLHSSFTTIQ SPIILPIDTK IRIEIKENYC DHDACPRIVA DGAVIRQGLS 

       250        260        270 
STTIEISATR SQADYVATTD LRSYIQRLQK TFIY 

« Hide

References

[1]"The complete genome sequence of the avian pathogen Mycoplasma gallisepticum strain R(low)."
Papazisi L., Gorton T.S., Kutish G., Markham P.F., Browning G.F., Nguyen D.K., Swartzell S., Madan A., Mahairas G., Geary S.J.
Microbiology 149:2307-2316(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: R(low / passage 15 / clone 2).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015450 Genomic DNA. Translation: AAP56895.1.
RefSeqNP_853327.1. NC_004829.2.

3D structure databases

ProteinModelPortalQ7NAU0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233150.MGA_0291.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP56895; AAP56895; MGA_0291.
GeneID1090041.
KEGGmga:MGA_0291.
PATRIC20008973. VBIMycGal115357_0617.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000115661.
KOK00858.
OMARSITNDM.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycMGAL710127:GC09-623-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_MYCGA
AccessionPrimary (citable) accession number: Q7NAU0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 15, 2003
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families