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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138L-tryptophanUniRule annotation1
Binding sitei189ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 11ATPUniRule annotation3
Nucleotide bindingi17 – 18ATPUniRule annotation2
Nucleotide bindingi150 – 152ATPUniRule annotation3
Nucleotide bindingi198 – 202ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:MYCGA5470
ORF Names:MGA_0293
OrganismiMycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Taxonomic identifieri710127 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000001418 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366451 – 350Tryptophan--tRNA ligaseAdd BLAST350

Proteomic databases

PRIDEiQ7NAT8.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ7NAT8.
SMRiQ7NAT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 18"HIGH" regionUniRule annotation9
Motifi198 – 202"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000059715.
KOiK01867.
OMAiQRMTQFK.

Family and domain databases

CDDicd00806. TrpRS_core. 1 hit.
Gene3Di3.40.50.620. 2 hits.
HAMAPiMF_00140_B. Trp_tRNA_synth_B. 1 hit.
InterProiView protein in InterPro
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
PfamiView protein in Pfam
PF00579. tRNA-synt_1b. 1 hit.
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7NAT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKIISGIQS TGSLHIGNYL GSISKNINLQ NKYQLNLFVA NLHTITVDFD
60 70 80 90 100
PTQARQNIIE LVKIYLASGF DTNKNNIFLQ SEINEHAALG HVLLCHTTMG
110 120 130 140 150
ELERMTQYKD KKQKFVQSNQ TIKIPTGLLT YPTLMAADIL LYQSDYVCVG
160 170 180 190 200
DDQKQHLELT RDIAIRMNKR YGELFKVPEP IIAKVGSRIM DLNDPSKKMS
210 220 230 240 250
KSSLSKKGII NLDDSREEVL SKIKSAKTDN LNKVNFDYKT QPEISNLVSI
260 270 280 290 300
YYGAINDHFN LGLKSAKFNK ALDEEVVPID IIKHFENKSY KDFKEELFEL
310 320 330 340 350
IWNILDNIQT NMKKITDEDV MRVLKSGKDK LLPIAQKTLL KVYQKLGMVI
Length:350
Mass (Da):39,947
Last modified:December 15, 2003 - v1
Checksum:i837FC309DB3836AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015450 Genomic DNA. Translation: AAP56897.2.

Genome annotation databases

EnsemblBacteriaiAAP56897; AAP56897; MGA_0293.
KEGGimga:MGA_0293.
PATRICifig|233150.7.peg.619.

Similar proteinsi

Entry informationi

Entry nameiSYW_MYCGA
AccessioniPrimary (citable) accession number: Q7NAT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome