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Q7NAT8

- SYW_MYCGA

UniProt

Q7NAT8 - SYW_MYCGA

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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei201 – 2011ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMGAL710127:GC09-625-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:MYCGA5470
ORF Names:MGA_0293
OrganismiMycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Taxonomic identifieri710127 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000001418: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Tryptophan--tRNA ligasePRO_0000136645Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi233150.MGA_0293.

Structurei

3D structure databases

ProteinModelPortaliQ7NAT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi10 – 189"HIGH" region
Motifi198 – 2025"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000059715.
KOiK01867.
OMAiYFIPDMH.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7NAT8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKIISGIQS TGSLHIGNYL GSISKNINLQ NKYQLNLFVA NLHTITVDFD
60 70 80 90 100
PTQARQNIIE LVKIYLASGF DTNKNNIFLQ SEINEHAALG HVLLCHTTMG
110 120 130 140 150
ELERMTQYKD KKQKFVQSNQ TIKIPTGLLT YPTLMAADIL LYQSDYVCVG
160 170 180 190 200
DDQKQHLELT RDIAIRMNKR YGELFKVPEP IIAKVGSRIM DLNDPSKKMS
210 220 230 240 250
KSSLSKKGII NLDDSREEVL SKIKSAKTDN LNKVNFDYKT QPEISNLVSI
260 270 280 290 300
YYGAINDHFN LGLKSAKFNK ALDEEVVPID IIKHFENKSY KDFKEELFEL
310 320 330 340 350
IWNILDNIQT NMKKITDEDV MRVLKSGKDK LLPIAQKTLL KVYQKLGMVI
Length:350
Mass (Da):39,947
Last modified:December 15, 2003 - v1
Checksum:i837FC309DB3836AC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015450 Genomic DNA. Translation: AAP56897.2.
RefSeqiNP_853329.2. NC_004829.2.

Genome annotation databases

EnsemblBacteriaiAAP56897; AAP56897; MGA_0293.
GeneIDi1090039.
KEGGimga:MGA_0293.
PATRICi20008977. VBIMycGal115357_0619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015450 Genomic DNA. Translation: AAP56897.2 .
RefSeqi NP_853329.2. NC_004829.2.

3D structure databases

ProteinModelPortali Q7NAT8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233150.MGA_0293.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP56897 ; AAP56897 ; MGA_0293 .
GeneIDi 1090039.
KEGGi mga:MGA_0293.
PATRICi 20008977. VBIMycGal115357_0619.

Phylogenomic databases

eggNOGi COG0180.
HOGENOMi HOG000059715.
KOi K01867.
OMAi YFIPDMH.

Enzyme and pathway databases

BioCyci MGAL710127:GC09-625-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_B. Trp_tRNA_synth_B.
InterProi IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the avian pathogen Mycoplasma gallisepticum strain R(low)."
    Papazisi L., Gorton T.S., Kutish G., Markham P.F., Browning G.F., Nguyen D.K., Swartzell S., Madan A., Mahairas G., Geary S.J.
    Microbiology 149:2307-2316(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R(low / passage 15 / clone 2).

Entry informationi

Entry nameiSYW_MYCGA
AccessioniPrimary (citable) accession number: Q7NAT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3