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Protein

Peptide deformylase

Gene

def

Organism
Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi114IronUniRule annotation1
Metal bindingi158IronUniRule annotation1
Active sitei159UniRule annotation1
Metal bindingi162IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processProtein biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciMGAL710127:G1GL5-743-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDFUniRule annotation
Alternative name(s):
Polypeptide deformylaseUniRule annotation
Gene namesi
Name:defUniRule annotation
Ordered Locus Names:MYCGA6410
ORF Names:MGA_0463
OrganismiMycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Taxonomic identifieri710127 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000001418 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000828001 – 196Peptide deformylaseAdd BLAST196

Structurei

3D structure databases

SMRiQ7NAK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000243507
KOiK01462

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.10, 1 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit
TIGRFAMsiTIGR00079 pept_deformyl, 1 hit

Sequencei

Sequence statusi: Complete.

Q7NAK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSKLKPTND WLVTDDNPKM REVCTEVKFP LSQEVLDIID KMLAYVDESF
60 70 80 90 100
DDNAEKYDIR PGIGIAANQL GLNQRFFYVH FTDFCQKEHR YLLINPEWID
110 120 130 140 150
KSLNKAYLAV GEGCLSVPKD KDGYVIRSET VKLKGFDYLT QKDVEISAHG
160 170 180 190
LLAMCLQHEM DHLEGKFYYD SINMMKPYFK KDEWVSIDQK VCDQCK
Length:196
Mass (Da):22,869
Last modified:June 15, 2010 - v2
Checksum:i70B660A827C7BD0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015450 Genomic DNA Translation: AAP56991.2
RefSeqiWP_011113901.1, NC_004829.2

Genome annotation databases

EnsemblBacteriaiAAP56991; AAP56991; MGA_0463
GeneIDi1089943
KEGGimga:MGA_0463
PATRICifig|233150.7.peg.718

Similar proteinsi

Entry informationi

Entry nameiDEF_MYCGA
AccessioniPrimary (citable) accession number: Q7NAK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 15, 2010
Last modified: May 23, 2018
This is version 81 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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