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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei255ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMGAL710127:G1GL5-828-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:MYCGA7130
ORF Names:MGA_0594
OrganismiMycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Taxonomic identifieri710127 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000001418 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001196001 – 498Glutamate--tRNA ligaseAdd BLAST498

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ7NAE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 20"HIGH" regionUniRule annotationAdd BLAST11
Motifi252 – 256"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000252720
KOiK01885
OMAiAYYAFDT

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q7NAE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIRTRYAP SPTGYFHIGG ARTALFNYLF AKHNNGEFIV RIEDTDIERN
60 70 80 90 100
VEDGAENQLY NLKWLNIFAD ESIWNPTQSG PYRQSEKLEV YQKYAYQLLE
110 120 130 140 150
EKKAYRCFCT PEELQKHRED LLKQYKPPIY SRKCFLLSEE QIHKNLADKI
160 170 180 190 200
PFTIRLLLRD NKEYSWNDLI RGNLIFNTSS MSDPVILKSN QIATYNFAVV
210 220 230 240 250
IDDHDMKISH ILRGEEHISN TPYQLAIKEA LGFKDEFVYG HLSIIVDETG
260 270 280 290 300
KKLSKRNLAV EQFVEGFRKK GYLAEALVNF IALLGWSHPD NIEILDLPTL
310 320 330 340 350
VKSFTIKNLS AAPSFFDIKK LNWISSEYIK NMDDVMYLAF IKPYVDLNEY
360 370 380 390 400
DEIKTKVNEI CLMFKNQLQY GYQINEIIKE SFVPHVGLSN LDQADLDFLK
410 420 430 440 450
SNPNYRQLLI SFKEKINQLD QVNDHNVKEI INWLAHQIKL GDLVLEKPLG
460 470 480 490
GKNLYMPLRI VLSNKKHGPE LNKVIALYDK QTILKNLDDA INYLTNAK
Length:498
Mass (Da):57,981
Last modified:December 15, 2003 - v1
Checksum:iD9643C717B49D8C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015450 Genomic DNA Translation: AAP57063.1
RefSeqiWP_011113976.1, NC_004829.2

Genome annotation databases

EnsemblBacteriaiAAP57063; AAP57063; MGA_0594
GeneIDi1090315
KEGGimga:MGA_0594
PATRICifig|233150.7.peg.803

Similar proteinsi

Entry informationi

Entry nameiSYE_MYCGA
AccessioniPrimary (citable) accession number: Q7NAE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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