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Q7NA61 (SYW_PHOLL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase
EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:plu0084
OrganismPhotorhabdus luminescens subsp. laumondii (strain TT01) [Complete proteome] [HAMAP]
Taxonomic identifier243265 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Photorhabdus ›

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 345345Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136657

Regions

Motif23 – 319"HIGH" region HAMAP-Rule MF_00140
Motif206 – 2105"KMSKS" region HAMAP-Rule MF_00140

Sites

Binding site2091ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7NA61 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 49BF433DEE8E6D66

FASTA34538,678
        10         20         30         40         50         60 
MNEPTVSETL NSQKPIVFSG AQPSGELTIG NYMGALRQWV KMQDDYDCIY CIVDQHAITV 

        70         80         90        100        110        120 
RQDPKELRKR TLDTLALYLA CGIDPEKSTI FVQSHVPQHA QLSWILNCYT YFGELSRMTQ 

       130        140        150        160        170        180 
FKDKSARHAE NINAGLFDYP VLMTADILVY QTNQVPVGID QKQHLELSRD IAQRFNAIYG 

       190        200        210        220        230        240 
NIFAVPEPFI PTGGARVMAL QDPEKKMSKS DDNRNNVIAL LEDPKSAAKK IKRAVTDSEE 

       250        260        270        280        290        300 
PPRVRYDLEQ KPGVSNLLDL LAGVTGKTIP ELEAEFEGQM YGHLKSAVAD AVSGMLTELQ 

       310        320        330        340 
ERFHYFRNDE ILLNKIMAEG AAKAKARAQI TLDKVYEAVG FIAHP

« Hide

References

[1]"The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens."
Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A., Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F., Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C., Lanois A., Powell K. expand/collapse author list , Siguier P., Vincent R., Wingate V., Zouine M., Glaser P., Boemare N., Danchin A., Kunst F.
Nat. Biotechnol. 21:1307-1313(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TT01.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX571859 Genomic DNA. Translation: CAE12379.1.
RefSeqNP_927454.1. NC_005126.1.

3D structure databases

ProteinModelPortalQ7NA61.
SMRQ7NA61. Positions 16-342.
ModBaseSearch...

Protein-protein interaction databases

STRING243265.plu0084.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE12379; CAE12379; plu0084.
GeneID2800032.
KEGGplu:plu0084.
PATRIC20503599. VBIPhoLum48522_0085.

Organism-specific databases

GenoListplu0084.
CMRSearch...

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000059940.
KOK01867.
OMAHDCLYCV.
ProtClustDBPRK00927.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYW_PHOLL
AccessionPrimary (citable) accession number: Q7NA61
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

SIMILARITY comments

Index of protein domains and families

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