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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei146L-tryptophanUniRule annotation1
Binding sitei197ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 24ATPUniRule annotation3
Nucleotide bindingi30 – 31ATPUniRule annotation2
Nucleotide bindingi158 – 160ATPUniRule annotation3
Nucleotide bindingi206 – 210ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPLUM243265:G1GTE-84-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:plu0084
OrganismiPhotorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Taxonomic identifieri243265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaePhotorhabdus
Proteomesi
  • UP000002514 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366571 – 345Tryptophan--tRNA ligaseAdd BLAST345

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi243265.plu0084

Structurei

3D structure databases

ProteinModelPortaliQ7NA61
SMRiQ7NA61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi23 – 31"HIGH" regionUniRule annotation9
Motifi206 – 210"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
HOGENOMiHOG000059940
KOiK01867
OMAiQRMTQFK
OrthoDBiPOG091H00I9

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q7NA61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEPTVSETL NSQKPIVFSG AQPSGELTIG NYMGALRQWV KMQDDYDCIY
60 70 80 90 100
CIVDQHAITV RQDPKELRKR TLDTLALYLA CGIDPEKSTI FVQSHVPQHA
110 120 130 140 150
QLSWILNCYT YFGELSRMTQ FKDKSARHAE NINAGLFDYP VLMTADILVY
160 170 180 190 200
QTNQVPVGID QKQHLELSRD IAQRFNAIYG NIFAVPEPFI PTGGARVMAL
210 220 230 240 250
QDPEKKMSKS DDNRNNVIAL LEDPKSAAKK IKRAVTDSEE PPRVRYDLEQ
260 270 280 290 300
KPGVSNLLDL LAGVTGKTIP ELEAEFEGQM YGHLKSAVAD AVSGMLTELQ
310 320 330 340
ERFHYFRNDE ILLNKIMAEG AAKAKARAQI TLDKVYEAVG FIAHP
Length:345
Mass (Da):38,678
Last modified:December 15, 2003 - v1
Checksum:i49BF433DEE8E6D66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571859 Genomic DNA Translation: CAE12379.1
RefSeqiWP_011144490.1, NC_005126.1

Genome annotation databases

EnsemblBacteriaiCAE12379; CAE12379; plu0084
KEGGiplu:plu0084

Similar proteinsi

Entry informationi

Entry nameiSYW_PHOLL
AccessioniPrimary (citable) accession number: Q7NA61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health