Reviewed, UniProtKB/Swiss-Prot Q7NA60 (GPH_PHOLL)

Names and origin

Protein names

Recommended name:
    Phosphoglycolate phosphatase
      Short name=PGPase
      Short name=PGP
    EC=3.1.3.18

Gene names

Ordered Locus Names:

plu0085

Organism

Photorhabdus luminescens subsp. laumondii [Complete proteome] [HAMAP]

Taxonomic identifier

141679 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Photorhabdus

Protein attributes

Sequence length	234 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress By similarity.
Catalytic activity	2-phosphoglycolate + H2O = glycolate + phosphate. HAMAP MF_00495
Cofactor	Chloride By similarity. Magnesium By similarity.
Pathway	Organic acid metabolism; glycolic acid biosynthesis; glycolic acid from 2-phosphoglycolic acid: step 1/1. HAMAP MF_00495
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the HAD-like hydrolase superfamily. CbbY/cbbZ/gph/yieH family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Ligand	Chloride Magnesium
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	chloride ion binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglycolate phosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 234	234	Phosphoglycolate phosphatase HAMAP MF_00495		PRO_0000238165
Sites
	Active site	15	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7NA60-1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: FBB53A378D878D56	FASTA	234	25,097
	10 20 30 40 50 60 MASKVLKGIR AIAFDLDGTL VDSAGGLADA LDQALLAKGL PAAGKERVAA WVGNGADIMV 70 80 90 100 110 120 ERALTWARTK LTAQLHKETR ELFDRFYETT VTTGSQLFPE VKVTLAELAK HNLPMGIITN 130 140 150 160 170 180 KPTPFIAPLL ASLDISEYFS LVLGGDDVKE KKPHPAPIYL TMGTFGLRKE ELLFVGDSRN 190 200 210 220 230 DILAAQAAGC PCVGLTYGYN YGESIALSNP DCILTNFSDL LSTIGLPSLK LQEA

References

[1]

"The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens." Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A., Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F., Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C., Lanois A., Powell K. , Siguier P., Vincent R., Wingate V., Zouine M., Glaser P., Boemare N., Danchin A., Kunst F. Nat. Biotechnol. 21:1307-1313(2003) [PubMed: 14528314] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TT01.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX571859 Genomic DNA. Translation: CAE12380.1.
RefSeq	NP_927455.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2800033.
GenomeReviews	Gene locus plu0085 in contig BX470251_GR.
KEGG	plu:plu0085.
NMPDR	fig|243265.1.peg.79.
Organism-specific databases
PhotoList	plu0085.
CMR	Search...
Phylogenomic databases
HOGENOM	Q7NA60.
OMA	Q7NA60. AVCEQFS.
Enzyme and pathway databases
BioCyc	PLUM243265:PLU0085-MON.
BRENDA	3.1.3.18. 308689.
Family and domain databases
HAMAP	MF_00495. [Tree]
InterPro	IPR005834. Dehalogen-like_hydro. IPR006439. HAD-SF_hydro_IA_v1. IPR006402. HAD-SF_hydro_IA_v3. IPR005833. Haloacid_DH/epoxide_hydro. IPR006346. PGP_bact. [Graphical view]
Pfam	PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00413. HADHALOGNASE.
TIGRFAMs	TIGR01549. HAD-SF-IA-v1. 1 hit. TIGR01509. HAD-SF-IA-v3. 1 hit. TIGR01449. PGP_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GPH_PHOLL

Accession

Primary (citable) accession number: Q7NA60

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	December 15, 2003
Last modified:	June 16, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)