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Q7N9V7

- BIOH_PHOLL

UniProt

Q7N9V7 - BIOH_PHOLL

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Protein

Pimeloyl-[acyl-carrier protein] methyl ester esterase

Gene

bioH

Organism
Photorhabdus luminescens subsp. laumondii (strain TT01)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.UniRule annotation

Catalytic activityi

Pimeloyl-[acyl-carrier protein] methyl ester + H2O = pimeloyl-[acyl-carrier protein] + methanol.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei22 – 221Substrate; via amide nitrogen and carbonyl oxygenUniRule annotation
Active sitei82 – 821NucleophileUniRule annotation
Active sitei207 – 2071UniRule annotation
Active sitei235 – 2351UniRule annotation
Binding sitei235 – 2351SubstrateUniRule annotation

GO - Molecular functioni

  1. carboxylic ester hydrolase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. biotin biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Keywords - Biological processi

Biotin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00078.

Names & Taxonomyi

Protein namesi
Recommended name:
Pimeloyl-[acyl-carrier protein] methyl ester esteraseUniRule annotation (EC:3.1.1.85UniRule annotation)
Alternative name(s):
Biotin synthesis protein BioHUniRule annotation
Carboxylesterase BioHUniRule annotation
Gene namesi
Name:bioHUniRule annotation
Ordered Locus Names:plu0204
OrganismiPhotorhabdus luminescens subsp. laumondii (strain TT01)
Taxonomic identifieri243265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
ProteomesiUP000002514: Chromosome

Organism-specific databases

GenoListiplu0204.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Pimeloyl-[acyl-carrier protein] methyl ester esterasePRO_0000204486Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi243265.plu0204.

Structurei

3D structure databases

ProteinModelPortaliQ7N9V7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni82 – 832Substrate bindingUniRule annotation
Regioni143 – 1475Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0596.
HOGENOMiHOG000028062.
KOiK02170.
OMAiFDKAAHA.
OrthoDBiEOG6FJNH9.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_01260. Carboxylester.
InterProiIPR029058. AB_hydrolase.
IPR010076. BioH.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01738. bioH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7N9V7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADLFWQTSD EGSRDLVLLH GWGLNAEVWR SIEMRCAPHF RLHLVDLPGY
60 70 80 90 100
GRSQKYGPMN LADMADEVWR YAPENALWLG WSLGGLVASR IALDHQDKVA
110 120 130 140 150
GLITVASSPH FSAESDWPGI KPEVLHDFEH QLSKDFQRTV ERFLALQTLG
160 170 180 190 200
TDSARQDARL LKSVVLAQPM PSVEVLHVGL EILRTEDLRQ PLAELAIPFL
210 220 230 240 250
RIYGYLDGLV PRKIINILDE KWPRSVSAMM RHAAHAPFIS HPDEFVGLLT
260
EFASREVLQG R
Length:261
Mass (Da):29,519
Last modified:December 15, 2003 - v1
Checksum:iA010A29E2A51B77A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571859 Genomic DNA. Translation: CAE12499.1.
RefSeqiNP_927568.1. NC_005126.1.

Genome annotation databases

EnsemblBacteriaiCAE12499; CAE12499; plu0204.
GeneIDi2800153.
KEGGiplu:plu0204.
PATRICi20503863. VBIPhoLum48522_0216.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571859 Genomic DNA. Translation: CAE12499.1 .
RefSeqi NP_927568.1. NC_005126.1.

3D structure databases

ProteinModelPortali Q7N9V7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243265.plu0204.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE12499 ; CAE12499 ; plu0204 .
GeneIDi 2800153.
KEGGi plu:plu0204.
PATRICi 20503863. VBIPhoLum48522_0216.

Organism-specific databases

GenoListi plu0204.

Phylogenomic databases

eggNOGi COG0596.
HOGENOMi HOG000028062.
KOi K02170.
OMAi FDKAAHA.
OrthoDBi EOG6FJNH9.

Enzyme and pathway databases

UniPathwayi UPA00078 .

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
HAMAPi MF_01260. Carboxylester.
InterProi IPR029058. AB_hydrolase.
IPR010076. BioH.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
TIGRFAMsi TIGR01738. bioH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TT01.

Entry informationi

Entry nameiBIOH_PHOLL
AccessioniPrimary (citable) accession number: Q7N9V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: December 15, 2003
Last modified: November 26, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3