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Q7N9V7

- BIOH_PHOLL

UniProt

Q7N9V7 - BIOH_PHOLL

Protein

Pimeloyl-[acyl-carrier protein] methyl ester esterase

Gene

bioH

Organism
Photorhabdus luminescens subsp. laumondii (strain TT01)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.UniRule annotation

    Catalytic activityi

    Pimeloyl-[acyl-carrier protein] methyl ester + H2O = pimeloyl-[acyl-carrier protein] + methanol.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei22 – 221Substrate; via amide nitrogen and carbonyl oxygenUniRule annotation
    Active sitei82 – 821NucleophileUniRule annotation
    Active sitei207 – 2071UniRule annotation
    Active sitei235 – 2351UniRule annotation
    Binding sitei235 – 2351SubstrateUniRule annotation

    GO - Molecular functioni

    1. carboxylic ester hydrolase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. biotin biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase, Serine esterase

    Keywords - Biological processi

    Biotin biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00078.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pimeloyl-[acyl-carrier protein] methyl ester esteraseUniRule annotation (EC:3.1.1.85UniRule annotation)
    Alternative name(s):
    Biotin synthesis protein BioHUniRule annotation
    Carboxylesterase BioHUniRule annotation
    Gene namesi
    Name:bioHUniRule annotation
    Ordered Locus Names:plu0204
    OrganismiPhotorhabdus luminescens subsp. laumondii (strain TT01)
    Taxonomic identifieri243265 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
    ProteomesiUP000002514: Chromosome

    Organism-specific databases

    GenoListiplu0204.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261Pimeloyl-[acyl-carrier protein] methyl ester esterasePRO_0000204486Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi243265.plu0204.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7N9V7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni82 – 832Substrate bindingUniRule annotation
    Regioni143 – 1475Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0596.
    HOGENOMiHOG000028062.
    KOiK02170.
    OMAiFDKAAHA.
    OrthoDBiEOG6FJNH9.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    HAMAPiMF_01260. Carboxylester.
    InterProiIPR029058. AB_hydrolase.
    IPR010076. BioH.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.
    TIGRFAMsiTIGR01738. bioH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7N9V7-1 [UniParc]FASTAAdd to Basket

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    MADLFWQTSD EGSRDLVLLH GWGLNAEVWR SIEMRCAPHF RLHLVDLPGY    50
    GRSQKYGPMN LADMADEVWR YAPENALWLG WSLGGLVASR IALDHQDKVA 100
    GLITVASSPH FSAESDWPGI KPEVLHDFEH QLSKDFQRTV ERFLALQTLG 150
    TDSARQDARL LKSVVLAQPM PSVEVLHVGL EILRTEDLRQ PLAELAIPFL 200
    RIYGYLDGLV PRKIINILDE KWPRSVSAMM RHAAHAPFIS HPDEFVGLLT 250
    EFASREVLQG R 261
    Length:261
    Mass (Da):29,519
    Last modified:December 15, 2003 - v1
    Checksum:iA010A29E2A51B77A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571859 Genomic DNA. Translation: CAE12499.1.
    RefSeqiNP_927568.1. NC_005126.1.
    WP_011144604.1. NC_005126.1.

    Genome annotation databases

    EnsemblBacteriaiCAE12499; CAE12499; plu0204.
    GeneIDi2800153.
    KEGGiplu:plu0204.
    PATRICi20503863. VBIPhoLum48522_0216.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571859 Genomic DNA. Translation: CAE12499.1 .
    RefSeqi NP_927568.1. NC_005126.1.
    WP_011144604.1. NC_005126.1.

    3D structure databases

    ProteinModelPortali Q7N9V7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243265.plu0204.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE12499 ; CAE12499 ; plu0204 .
    GeneIDi 2800153.
    KEGGi plu:plu0204.
    PATRICi 20503863. VBIPhoLum48522_0216.

    Organism-specific databases

    GenoListi plu0204.

    Phylogenomic databases

    eggNOGi COG0596.
    HOGENOMi HOG000028062.
    KOi K02170.
    OMAi FDKAAHA.
    OrthoDBi EOG6FJNH9.

    Enzyme and pathway databases

    UniPathwayi UPA00078 .

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    HAMAPi MF_01260. Carboxylester.
    InterProi IPR029058. AB_hydrolase.
    IPR010076. BioH.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    TIGRFAMsi TIGR01738. bioH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TT01.

    Entry informationi

    Entry nameiBIOH_PHOLL
    AccessioniPrimary (citable) accession number: Q7N9V7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3