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Protein

HTH-type transcriptional regulator MalT

Gene

malT

Organism
Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box): 5'-GGA[TG]GA-3'.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi39 – 468ATPUniRule annotation
DNA bindingi856 – 87520H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Carbohydrate metabolism, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator MalTUniRule annotation
Alternative name(s):
ATP-dependent transcriptional activator MalTUniRule annotation
Gene namesi
Name:malTUniRule annotation
Ordered Locus Names:plu0471
OrganismiPhotorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Taxonomic identifieri243265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
Proteomesi
  • UP000002514 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 904904HTH-type transcriptional regulator MalTPRO_0000184166Add
BLAST

Interactioni

Subunit structurei

Monomer in solution but oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose.UniRule annotation

Protein-protein interaction databases

STRINGi243265.plu0471.

Structurei

3D structure databases

ProteinModelPortaliQ7N976.
SMRiQ7N976. Positions 447-806.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini832 – 89766HTH luxR-typeUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH luxR-type DNA-binding domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG41061ZR. Bacteria.
COG2909. LUCA.
HOGENOMiHOG000218261.
KOiK03556.
OMAiSDWVSNA.
OrthoDBiEOG69GZGV.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
HAMAPiMF_01247. HTH_type_MalT.
InterProiIPR027417. P-loop_NTPase.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR011990. TPR-like_helical_dom.
IPR023768. Tscrpt_reg_HTH_MalT.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF48452. SSF48452. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7N976-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIPSKLSRP VRLNNTVLRE RLLIRLNESS NYRLVLITSP AGYGKTTLVS
60 70 80 90 100
QWAAGQDNLG WYSLDESDNQ PERFASYLIA ALQQATQGHC VKSEVLAQKH
110 120 130 140 150
QYANLPALFA QLFIELSEWR RPIFLVIDDY HLIVNNMIHE AMRFFLRHQP
160 170 180 190 200
ENLTLTILSR NLPSLGVANL RVREQLLEID SQQLAFDYQE TQQFFDKRLT
210 220 230 240 250
TSLDADDCKR LCNEVAGWAT ALQLIALSAR QSCDAAELSA KRLSGINAGH
260 270 280 290 300
LSDYLVDEVL NQVGSSTREF LLRSSILRSM NDGLIVRLTG EENGQQRLEE
310 320 330 340 350
TERQGLFIQR MDDSGEWFRF HPLFASFLRQ RCQWEMALQL PELHRAAAEG
360 370 380 390 400
WLAQGYPGEA IHHALAAGDT AMLRDILLQH AWSLFNHSEL SLLEECMNAL
410 420 430 440 450
PYEQLLESPR LVLLQAWLAQ SQHRYSEVNT LLNQAEQALQ QKQIAIEPDL
460 470 480 490 500
LAEFDALRAQ VAMNSGKPEM ADKLAKQALA ALLPQNEYSR IVATSVEGEV
510 520 530 540 550
LHCRGELADA LARMQQTEQL ARRFHVHHYA LWALLQQSEI LLAQGYLQTA
560 570 580 590 600
YETQNKAFEL IREQHLEQLP MHEFLLRIRS QLLWCWSRLD EAEEAARRGL
610 620 630 640 650
EVLSNFQPQQ QLQCLTQLAK CSLTRGDIDN ARRYLARCEN LLSNGQYHRD
660 670 680 690 700
WRTNTDKLRV IIWQSMDDKS AAIRWLAQTE RPESVSNHFN QGQWRNIARA
710 720 730 740 750
QILLGLYDEA ESILDTLNQH ARELQLISDL NRNLLLCNLL YWHIGRKSEA
760 770 780 790 800
QSALIEALSL ANRTGFISHF VIEGELMAQQ LRQLIQLNTL SELELHRAQR
810 820 830 840 850
ILRDINRQHR HKFAHFDESF VTQLLTHPDV PELIRNSPLT QREWQVLGLI
860 870 880 890 900
YSGYSNDQIA AELDVATTTI KTHIRNLYQK LGIANRQEAI QQAQQLMQMM

GLGV
Length:904
Mass (Da):103,872
Last modified:December 15, 2003 - v1
Checksum:i84FC3A19038FF779
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571860 Genomic DNA. Translation: CAE12766.1.
RefSeqiWP_011144857.1. NC_005126.1.

Genome annotation databases

EnsemblBacteriaiCAE12766; CAE12766; plu0471.
KEGGiplu:plu0471.
PATRICi20504449. VBIPhoLum48522_0510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571860 Genomic DNA. Translation: CAE12766.1.
RefSeqiWP_011144857.1. NC_005126.1.

3D structure databases

ProteinModelPortaliQ7N976.
SMRiQ7N976. Positions 447-806.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243265.plu0471.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE12766; CAE12766; plu0471.
KEGGiplu:plu0471.
PATRICi20504449. VBIPhoLum48522_0510.

Phylogenomic databases

eggNOGiENOG41061ZR. Bacteria.
COG2909. LUCA.
HOGENOMiHOG000218261.
KOiK03556.
OMAiSDWVSNA.
OrthoDBiEOG69GZGV.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
HAMAPiMF_01247. HTH_type_MalT.
InterProiIPR027417. P-loop_NTPase.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR011990. TPR-like_helical_dom.
IPR023768. Tscrpt_reg_HTH_MalT.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF48452. SSF48452. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15139 / CIP 105565 / TT01.

Entry informationi

Entry nameiMALT_PHOLL
AccessioniPrimary (citable) accession number: Q7N976
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: December 15, 2003
Last modified: March 16, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.