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Q7N954 (PUR9_PHOLL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:plu0495
OrganismPhotorhabdus luminescens subsp. laumondii (strain TT01) [Complete proteome] [HAMAP]
Taxonomic identifier243265 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 529529Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000018924

Sequences

Sequence LengthMass (Da)Tools
Q7N954 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 3680DA643CC313F8

FASTA52957,683
        10         20         30         40         50         60 
MQQLRPIHRA LLSVSDKSGV VEFAKALSQR GVELLSTGGT ARLLAESDLK VTEVSDYTGF 

        70         80         90        100        110        120 
PEMMDGRVKT LHPKVHGGIL GRRGQDDEIM AQHQISPIDM VVVNLYPFAQ TVAKPDCTLA 

       130        140        150        160        170        180 
DAVENIDIGG PTMVRSAAKN HKDVAIVVNS KDYKKIIEEM DNNQGSLTQS TRFDLAIKAF 

       190        200        210        220        230        240 
EHTAAYDSMI ANYFGKLVPP YHGDTTQPSG RFPRTLNLNF IKKQDMRYGE NSHQDAAFYI 

       250        260        270        280        290        300 
EENLSESSIA TATQLQGKAL SYNNIADTDA ALECVKEFVE PACVIVKHAN PCGVAIGKDI 

       310        320        330        340        350        360 
HEAYDSAFKT DPTSAFGGII AFNRELDIKT AQAIIDRQFV EVIIAPSVNK DVLPVLATKQ 

       370        380        390        400        410        420 
NIRVLVCGEW EDRAAGLDFK RVNGGLLVQD RDLGMVAVTN LRVVSKRHPT EQEMKDALFC 

       430        440        450        460        470        480 
WKVAKFVKSN AIVYAKNDMT IGIGAGQMSR VYSAKIAGIK AADEGLEVQG CAMASDAFFP 

       490        500        510        520 
FRDGIDAAAA VGVSCIIQPG GSIRDDEVIT AADEHGIAMI FTGMRHFRH 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571860 Genomic DNA. Translation: CAE12790.1.
RefSeqNP_927848.1. NC_005126.1.

3D structure databases

ProteinModelPortalQ7N954.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243265.plu0495.

Proteomic databases

PRIDEQ7N954.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE12790; CAE12790; plu0495.
GeneID2800445.
KEGGplu:plu0495.
PATRIC20504501. VBIPhoLum48522_0536.

Organism-specific databases

GenoListplu0495.
CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230372.
KOK00602.
OMARAFKTDP.
OrthoDBEOG6QCDFF.

Enzyme and pathway databases

UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_PHOLL
AccessionPrimary (citable) accession number: Q7N954
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 15, 2003
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways