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Q7N954

- PUR9_PHOLL

UniProt

Q7N954 - PUR9_PHOLL

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, plu0495
Organism
Photorhabdus luminescens subsp. laumondii (strain TT01)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:plu0495
OrganismiPhotorhabdus luminescens subsp. laumondii (strain TT01)
Taxonomic identifieri243265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
ProteomesiUP000002514: Chromosome

Organism-specific databases

GenoListiplu0495.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000018924Add
BLAST

Proteomic databases

PRIDEiQ7N954.

Interactioni

Protein-protein interaction databases

STRINGi243265.plu0495.

Structurei

3D structure databases

ProteinModelPortaliQ7N954.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7N954-1 [UniParc]FASTAAdd to Basket

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MQQLRPIHRA LLSVSDKSGV VEFAKALSQR GVELLSTGGT ARLLAESDLK    50
VTEVSDYTGF PEMMDGRVKT LHPKVHGGIL GRRGQDDEIM AQHQISPIDM 100
VVVNLYPFAQ TVAKPDCTLA DAVENIDIGG PTMVRSAAKN HKDVAIVVNS 150
KDYKKIIEEM DNNQGSLTQS TRFDLAIKAF EHTAAYDSMI ANYFGKLVPP 200
YHGDTTQPSG RFPRTLNLNF IKKQDMRYGE NSHQDAAFYI EENLSESSIA 250
TATQLQGKAL SYNNIADTDA ALECVKEFVE PACVIVKHAN PCGVAIGKDI 300
HEAYDSAFKT DPTSAFGGII AFNRELDIKT AQAIIDRQFV EVIIAPSVNK 350
DVLPVLATKQ NIRVLVCGEW EDRAAGLDFK RVNGGLLVQD RDLGMVAVTN 400
LRVVSKRHPT EQEMKDALFC WKVAKFVKSN AIVYAKNDMT IGIGAGQMSR 450
VYSAKIAGIK AADEGLEVQG CAMASDAFFP FRDGIDAAAA VGVSCIIQPG 500
GSIRDDEVIT AADEHGIAMI FTGMRHFRH 529
Length:529
Mass (Da):57,683
Last modified:December 15, 2003 - v1
Checksum:i3680DA643CC313F8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571860 Genomic DNA. Translation: CAE12790.1.
RefSeqiNP_927848.1. NC_005126.1.

Genome annotation databases

EnsemblBacteriaiCAE12790; CAE12790; plu0495.
GeneIDi2800445.
KEGGiplu:plu0495.
PATRICi20504501. VBIPhoLum48522_0536.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571860 Genomic DNA. Translation: CAE12790.1 .
RefSeqi NP_927848.1. NC_005126.1.

3D structure databases

ProteinModelPortali Q7N954.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243265.plu0495.

Proteomic databases

PRIDEi Q7N954.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE12790 ; CAE12790 ; plu0495 .
GeneIDi 2800445.
KEGGi plu:plu0495.
PATRICi 20504501. VBIPhoLum48522_0536.

Organism-specific databases

GenoListi plu0495.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TT01.

Entry informationi

Entry nameiPUR9_PHOLL
AccessioniPrimary (citable) accession number: Q7N954
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 15, 2003
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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