Q7N8S4 (ARGA_PHOLL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Amino-acid acetyltransferase
EC=2.3.1.1

Alternative name(s):
N-acetylglutamate synthase
Short name=AGS
Short name=NAGS

Gene names

Name:	argA
Ordered Locus Names:	plu0644

Organism

Photorhabdus luminescens subsp. laumondii (strain TT01) [Complete proteome] [HAMAP]

Taxonomic identifier

243265 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Photorhabdus

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate. HAMAP MF_01105
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4. HAMAP MF_01105
Subunit structure	Homohexamer Probable.
Subcellular location	Cytoplasm Probable HAMAP MF_01105.
Sequence similarities	Belongs to the acetyltransferase family. ArgA subfamily. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acetyl-CoA:L-glutamate N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	Amino-acid acetyltransferase HAMAP MF_01105		PRO_0000186797
Regions
	Domain	295 – 433	139	N-acetyltransferase

Sequences

	Sequence		Length	Mass (Da)
	Q7N8S4 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 89301D223D0E8F25	FASTA	448	50,356
	10 20 30 40 50 60 MKERSTELVE GFRHSVPYIN AHRGKTFVIM LGGEAIAHEN FTNIINDIGL LHSLGIRLVV 70 80 90 100 110 120 VYGARPQIEQ NLADHHYEPV YHKHTRVTDN KTLELVKQSA GLLQLDITAR LSMNLNNTPL 130 140 150 160 170 180 QGANINVVSG NFIIAQPLGV DDGVDYCHSG KIRRIDEHAI NRQLDNGAIV LIGPVAVSVT 190 200 210 220 230 240 GESFNLAFED VATQLAIKLQ AEKLIGFCST QGVQDKDGKI LSEVFLNQAP ELIKELEVKG 250 260 270 280 290 300 DYYSGTVCFL RSAIKACRRG VRRSHLLSYQ ADGSLLQELF SRDGIGTQIV MESAEQIRRA 310 320 330 340 350 360 NINDIGGILE LIRPLEQQGI LVRRSREQLE REIDKFIIIE RDNLTIACAA LYPYPEEKIG 370 380 390 400 410 420 EMACLAVNPK YRSSLRGEVL LNRIAEHAKQ LGLEKLFVLT TRSIHWFQER GFEPAELSML 430 440 PIQKQVLYNY QRRSKILMLN LEPQPGFT

References

[1]

"The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens." Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A., Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F., Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C., Lanois A., Powell K. , Siguier P., Vincent R., Wingate V., Zouine M., Glaser P., Boemare N., Danchin A., Kunst F. Nat. Biotechnol. 21:1307-1313(2003) [PubMed: 14528314] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TT01.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX571861 Genomic DNA. Translation: CAE12939.1.
RefSeq	NP_927989.1. NC_005126.1.
3D structure databases
ProteinModelPortal	Q7N8S4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2800598.
GenomeReviews	Gene locus plu0644 in contig BX470251_GR.
KEGG	plu:plu0644.
NMPDR	fig|243265.1.peg.613.
PATRIC	20504851. VBIPhoLum48522_0707.
Organism-specific databases
GenoList	plu0644.
CMR	Search...
Phylogenomic databases
HOGENOM	HBG545264.
OMA	AFNLAME.
PhylomeDB	Q7N8S4.
ProtClustDB	PRK05279.
Enzyme and pathway databases
BioCyc	PLUM243265:PLU0644-MONOMER.
Family and domain databases
HAMAP	MF_01105. N-acetyl_glu_synth. [Tree]
InterPro	IPR000182. AcTrfase_GCN5-related_dom. IPR016181. Acyl_CoA_acyltransferase. IPR001048. Asp/Glu/Uridylate_kinase. IPR010167. NH2A_AcTrfase_ArgA. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit. G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
KO	K14682.
Pfam	PF00696. AA_kinase. 1 hit. PF00583. Acetyltransf_1. 1 hit. [Graphical view]
PIRSF	PIRSF000423. ArgA. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit. SSF55729. Acyl_CoA_acyltransferase. 1 hit.
TIGRFAMs	TIGR01890. N-Ac-Glu-synth. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGA_PHOLL

Accession

Primary (citable) accession number: Q7N8S4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program