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Q7N8N4 (LPXB_PHOLL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:plu0685
OrganismPhotorhabdus luminescens subsp. laumondii (strain TT01) [Complete proteome] [HAMAP]
Taxonomic identifier243265 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlipid-A-disaccharide synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 389389Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_0000190174

Sequences

Sequence LengthMass (Da)Tools
Q7N8N4 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 9A5984F63DCA842E

FASTA38943,122
        10         20         30         40         50         60 
MATISSIDSL RPLTIGLIAG ETSGDILGAG LIRALKAKVP NARFVGVAGP LMQAEGCEAW 

        70         80         90        100        110        120 
YEMEELAVMG IVEVLGRLPR LLKIRKDLTT RFTELKPDVF VGIDAPDFNI TLEGRLKQRG 

       130        140        150        160        170        180 
IRTIHYVSPS VWAWRQKRVF KIGKATDMVL AFLPFEKAFY DKFNVPCRFI GHTMADAMPL 

       190        200        210        220        230        240 
QPNKATAREL LGILPESVCL ALLPGSRHSE VEMLSADFLK TAQLLKRNIP DLHVFVPLVN 

       250        260        270        280        290        300 
AKRREQFERI KQEVAPELNV HLVDGKAREI MIASDAALLA SGTAALECML AKCPMVVGYR 

       310        320        330        340        350        360 
MKPLTFWLAK RLVKTPYVSL PNLLSGEELV KELLQEKCQP QKLADELLPL LQGSEKVGAL 

       370        380 
KQTFLHLHKS IRCNADEQAA QAVLELAGK 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571861 Genomic DNA. Translation: CAE12980.1.
RefSeqNP_928030.1. NC_005126.1.

3D structure databases

ProteinModelPortalQ7N8N4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243265.plu0685.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE12980; CAE12980; plu0685.
GeneID2800642.
KEGGplu:plu0685.
PATRIC20504953. VBIPhoLum48522_0755.

Organism-specific databases

GenoListplu0685.
CMRSearch...

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018003.
KOK00748.
OMAVSPITYR.
OrthoDBEOG6FBWZR.

Enzyme and pathway databases

UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_PHOLL
AccessionPrimary (citable) accession number: Q7N8N4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways