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Q7N8N4

- LPXB_PHOLL

UniProt

Q7N8N4 - LPXB_PHOLL

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Photorhabdus luminescens subsp. laumondii (strain TT01)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00359; UER00481.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:plu0685
    OrganismiPhotorhabdus luminescens subsp. laumondii (strain TT01)
    Taxonomic identifieri243265 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
    ProteomesiUP000002514: Chromosome

    Organism-specific databases

    GenoListiplu0685.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 389389Lipid-A-disaccharide synthasePRO_0000190174Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243265.plu0685.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7N8N4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7N8N4-1 [UniParc]FASTAAdd to Basket

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    MATISSIDSL RPLTIGLIAG ETSGDILGAG LIRALKAKVP NARFVGVAGP    50
    LMQAEGCEAW YEMEELAVMG IVEVLGRLPR LLKIRKDLTT RFTELKPDVF 100
    VGIDAPDFNI TLEGRLKQRG IRTIHYVSPS VWAWRQKRVF KIGKATDMVL 150
    AFLPFEKAFY DKFNVPCRFI GHTMADAMPL QPNKATAREL LGILPESVCL 200
    ALLPGSRHSE VEMLSADFLK TAQLLKRNIP DLHVFVPLVN AKRREQFERI 250
    KQEVAPELNV HLVDGKAREI MIASDAALLA SGTAALECML AKCPMVVGYR 300
    MKPLTFWLAK RLVKTPYVSL PNLLSGEELV KELLQEKCQP QKLADELLPL 350
    LQGSEKVGAL KQTFLHLHKS IRCNADEQAA QAVLELAGK 389
    Length:389
    Mass (Da):43,122
    Last modified:December 15, 2003 - v1
    Checksum:i9A5984F63DCA842E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571861 Genomic DNA. Translation: CAE12980.1.
    RefSeqiNP_928030.1. NC_005126.1.
    WP_011145061.1. NC_005126.1.

    Genome annotation databases

    EnsemblBacteriaiCAE12980; CAE12980; plu0685.
    GeneIDi2800642.
    KEGGiplu:plu0685.
    PATRICi20504953. VBIPhoLum48522_0755.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571861 Genomic DNA. Translation: CAE12980.1 .
    RefSeqi NP_928030.1. NC_005126.1.
    WP_011145061.1. NC_005126.1.

    3D structure databases

    ProteinModelPortali Q7N8N4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243265.plu0685.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE12980 ; CAE12980 ; plu0685 .
    GeneIDi 2800642.
    KEGGi plu:plu0685.
    PATRICi 20504953. VBIPhoLum48522_0755.

    Organism-specific databases

    GenoListi plu0685.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TT01.

    Entry informationi

    Entry nameiLPXB_PHOLL
    AccessioniPrimary (citable) accession number: Q7N8N4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3