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Q7N8L5 (CYSI_PHOLL) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Sulfite reductase [NADPH] hemoprotein beta-component
Short name=SiR-HP
Short name=SiRHP
EC=1.8.1.2
Gene names
Name:cysI
Ordered Locus Names:plu0704
OrganismPhotorhabdus luminescens subsp. laumondii (strain TT01) [Complete proteome] [HAMAP]
Taxonomic identifier243265 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Photorhabdus

Protein attributes

Sequence length576 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate By similarity. HAMAP MF_01540

Catalytic activity

H2S + 3 NADP+ + 3 H2O = sulfite + 3 NADPH. HAMAP MF_01540

Cofactor

Binds 1 siroheme per subunit By similarity. HAMAP MF_01540

Binds 1 4Fe-4S cluster per subunit By similarity. HAMAP MF_01540

Pathway

Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1. HAMAP MF_01540

Subunit structure

Alpha(8)-beta8. The alpha component is a flavoprotein, the beta component is a hemoprotein By similarity.

Sequence similarities

Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 576576Sulfite reductase [NADPH] hemoprotein beta-component HAMAP MF_01540
PRO_0000199903

Sites

Metal binding4351Iron-sulfur (4Fe-4S) By similarity
Metal binding4411Iron-sulfur (4Fe-4S) By similarity
Metal binding4801Iron-sulfur (4Fe-4S) By similarity
Metal binding4841Iron (siroheme axial ligand) By similarity
Metal binding4841Iron-sulfur (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7N8L5 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 3CA6B1166715B15D

FASTA57664,829
        10         20         30         40         50         60 
MNDKQHGPFI VEGKLADSER MKQESNFLRG TISEDLTNGL TGGFEGDNFL LIRFHGMYQQ 

        70         80         90        100        110        120 
DDRDIRAERA EQKLEPRHAI MLRCRLPGGV ITPQQWLGID KFAEENTLYG SIRLTNRQTF 

       130        140        150        160        170        180 
QFHGILKGKV KLAHQLLNQV GLDSLATAND VNRNVLCTSN PIQSELHQQA YEWAKKISEH 

       190        200        210        220        230        240 
LLPRTRAYAE LWLDKEKVAT TDEEPILGST YLPRKFKTTV VIPPQNDVDL HANDLNFIAI 

       250        260        270        280        290        300 
AEGSKLVGFN VLVGGGLAMT HGDKNTYPSM ASEFGYIPLE HTLAIAEAVV TTQRDWGNRT 

       310        320        330        340        350        360 
ERKNAKTKYT LERVGVETFK AEVERRAGVK FEAIRPYEFT GRGDQIGWLK GIDDKWHLTL 

       370        380        390        400        410        420 
FIENGRLLDY PGKPLKSGVA EIAKIHKGDF RLTANQNLII AGIPESEKQR IETIACRHGL 

       430        440        450        460        470        480 
IDDKTTVQRK NSMACVSFPT CPLAMAEAER FLPEFVTHVE QLMNKHGIGD EHIVLRVTGC 

       490        500        510        520        530        540 
PNGCARAMLA EVGLVGKALD RYNLHLGGNR IGTRIPRMYK ENISSQAILS IMDELIGRWA 

       550        560        570 
TGRQPNEGFG DFLIRTDIIK PVLDSARDFY DWQEAV

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX571861 Genomic DNA. Translation: CAE12999.1.
RefSeqNP_928049.1. NC_005126.1.

3D structure databases

ProteinModelPortalQ7N8L5.
SMRQ7N8L5. Positions 81-571.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2800667.
GenomeReviewsGene locus plu0704 in contig BX470251_GR.
KEGGplu:plu0704.
NMPDRfig|243265.1.peg.673.
PATRIC20505005. VBIPhoLum48522_0775.

Organism-specific databases

GenoListplu0704.
CMRSearch...

Phylogenomic databases

HOGENOMHBG626671.
OMAWIEGEDG.
PhylomeDBQ7N8L5.
ProtClustDBPRK13504.

Enzyme and pathway databases

BioCycPLUM243265:PLU0704-MONOMER.

Family and domain databases

HAMAPMF_01540. CysI.
[Tree]
InterProIPR011786. CysI.
IPR005117. NiRdtase/SiRdtase_haem-b_fer.
IPR006067. NO2/SO3_Rdtase_4Fe4S_dom.
IPR006066. NO2/SO3_Rdtase_FeS/sirohaem_BS.
[Graphical view]
Gene3DG3DSA:3.90.480.10. G3DSA:3.90.480.10. 2 hits.
KOK00381.
PfamPF01077. NIR_SIR. 1 hit.
PF03460. NIR_SIR_ferr. 2 hits.
[Graphical view]
PRINTSPR00397. SIROHAEM.
SUPFAMSSF55124. NiR_SiRalpha_1/3. 2 hits.
TIGRFAMsTIGR02041. CysI. 1 hit.
PROSITEPS00365. NIR_SIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYSI_PHOLL
AccessionPrimary (citable) accession number: Q7N8L5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 15, 2003
Last modified: January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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