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Q7N8K4 (SURE_PHOLL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5'/3'-nucleotidase SurE

EC=3.1.3.5
EC=3.1.3.6
Alternative name(s):
Exopolyphosphatase
EC=3.6.1.11
Nucleoside monophosphate phosphohydrolase
Gene names
Name:surE
Ordered Locus Names:plu0716
OrganismPhotorhabdus luminescens subsp. laumondii (strain TT01) [Complete proteome] [HAMAP]
Taxonomic identifier243265 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs By similarity. HAMAP-Rule MF_00060

Catalytic activity

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP-Rule MF_00060

A 3'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP-Rule MF_00060

(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate. HAMAP-Rule MF_00060

Cofactor

Binds 1 divalent metal cation per subunit By similarity.

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00060.

Sequence similarities

Belongs to the SurE nucleotidase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3'-nucleotidase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

5'-nucleotidase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

exopolyphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleotide binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2542545'/3'-nucleotidase SurE HAMAP-Rule MF_00060
PRO_0000111826

Sites

Metal binding91Divalent metal cation By similarity
Metal binding101Divalent metal cation By similarity
Metal binding401Divalent metal cation By similarity
Metal binding931Divalent metal cation By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7N8K4 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 56DAFE9896594CE4

FASTA25427,288
        10         20         30         40         50         60 
MLRILLSNDD GVTAPGIQVL AAALRENYHV QVVAPDRNRS GASNALTLDR SLSVNTLENG 

        70         80         90        100        110        120 
DISVLGGTPT DCVYLGVNRL VLPRPEIVVS GINRGPNLGD DVIYSGTVAA AMEGRHLGLP 

       130        140        150        160        170        180 
ALAISLNGEL HYQTAAEITC RLLQMLQTTP LRAGNILNVN VPDLPLEHIK GFRVTRCGSR 

       190        200        210        220        230        240 
HAAEEVYSMQ DPKGNMLYWL GPPGDKHDAG PETDFAAVEQ GYVSITPLQV DLTAYKAQAL 

       250 
VRDWLAKAEV DGEC 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571861 Genomic DNA. Translation: CAE13011.1.
RefSeqNP_928061.1. NC_005126.1.

3D structure databases

ProteinModelPortalQ7N8K4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243265.plu0716.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE13011; CAE13011; plu0716.
GeneID2800679.
KEGGplu:plu0716.
PATRIC20505029. VBIPhoLum48522_0787.

Organism-specific databases

GenoListplu0716.
CMRSearch...

Phylogenomic databases

eggNOGCOG0496.
HOGENOMHOG000122500.
KOK03787.
OMADCVHIAL.
OrthoDBEOG68WR45.
ProtClustDBPRK00346.

Family and domain databases

Gene3D3.40.1210.10. 1 hit.
HAMAPMF_00060. SurE.
InterProIPR002828. SurE-like_Pase/nucleotidase.
[Graphical view]
PfamPF01975. SurE. 1 hit.
[Graphical view]
SUPFAMSSF64167. SSF64167. 1 hit.
TIGRFAMsTIGR00087. surE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSURE_PHOLL
AccessionPrimary (citable) accession number: Q7N8K4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families