Q7N8D1 (HIS42_PHOLL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2
EC=5.3.1.16

Alternative name(s):
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase 2

Gene names

Name:	hisA2
Ordered Locus Names:	plu0797

Organism

Photorhabdus luminescens subsp. laumondii (strain TT01) [Complete proteome] [HAMAP]

Taxonomic identifier

243265 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Photorhabdus

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-phosphoribosyl)imidazole-4-carboxamide. HAMAP MF_01014
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. HAMAP MF_01014
Subcellular location	Cytoplasm By similarity HAMAP MF_01014.
Sequence similarities	Belongs to the HisA/HisF family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 258	258	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2 HAMAP MF_01014		PRO_0000142032
Sites
	Active site	14	1	Proton acceptor By similarity
	Active site	140	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7N8D1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 0D890FE0FC66E410	FASTA	258	27,350
	10 20 30 40 50 60 MISKETFEIF PSVDIVDGIA MTSNSAIRLT RGESSTLRRP LGTPAEVALA WQNAGAKWIH 70 80 90 100 110 120 VVDLDAASGR GSNSHLIADV LAAVDINVQV CGGIRDETIL RKVLATGCQR VNLGTAALEN 130 140 150 160 170 180 PDWCAQAIAE YGDKIAIALD VKSTSEGYQL ATHGWNVSKG NLWDLLERLD KQGCQRYVVT 190 200 210 220 230 240 DVERGGMMSS PNFTLLQEVC AKTSSPVIAG GGVSSLDDLR ALADLSTIGV EGAILGQALH 250 IGKVPLEDAL AATQSPRR

References

[1]

"The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens." Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A., Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F., Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C., Lanois A., Powell K. , Siguier P., Vincent R., Wingate V., Zouine M., Glaser P., Boemare N., Danchin A., Kunst F. Nat. Biotechnol. 21:1307-1313(2003) [PubMed: 14528314] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TT01.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX571861 Genomic DNA. Translation: CAE13092.1.
RefSeq	NP_928142.1. NC_005126.1.
3D structure databases
ProteinModelPortal	Q7N8D1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2800760.
GenomeReviews	Gene locus plu0797 in contig BX470251_GR.
KEGG	plu:plu0797.
NMPDR	fig|243265.1.peg.766.
PATRIC	20505205. VBIPhoLum48522_0876.
Organism-specific databases
GenoList	plu0797.
CMR	Search...
Phylogenomic databases
HOGENOM	HBG541613.
OMA	CARYVVT.
PhylomeDB	Q7N8D1.
ProtClustDB	PRK00748.
Enzyme and pathway databases
BioCyc	PLUM243265:PLU0797-MONOMER.
Family and domain databases
HAMAP	MF_01014. HisA. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR006062. His_biosynth. IPR023016. Isoase_HisA. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01814. K01817.
Pfam	PF00977. His_biosynth. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS42_PHOLL

Accession

Primary (citable) accession number: Q7N8D1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program