Reviewed, UniProtKB/Swiss-Prot Q7N8D1 (HIS42_PHOLL)

Names and origin

Protein names

Recommended name:
    1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2
    EC=5.3.1.16
Alternative name(s):
    Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase 2

Gene names

Name:	hisA2
Ordered Locus Names:	plu0797

Organism

Photorhabdus luminescens subsp. laumondii [Complete proteome] [HAMAP]

Taxonomic identifier

141679 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Photorhabdus

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-phosphoribosyl)imidazole-4-carboxamide. HAMAP MF_01014
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. HAMAP MF_01014
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the hisA/hisF family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 258	258	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2 HAMAP MF_01014		PRO_0000142032
Sites
	Active site	14	1	Proton acceptor By similarity
	Active site	140	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7N8D1-1 [UniParc]. Last modified December 15, 2003. Version 1. Checksum: 0D890FE0FC66E410	FASTA	258	27,350
	10 20 30 40 50 60 MISKETFEIF PSVDIVDGIA MTSNSAIRLT RGESSTLRRP LGTPAEVALA WQNAGAKWIH 70 80 90 100 110 120 VVDLDAASGR GSNSHLIADV LAAVDINVQV CGGIRDETIL RKVLATGCQR VNLGTAALEN 130 140 150 160 170 180 PDWCAQAIAE YGDKIAIALD VKSTSEGYQL ATHGWNVSKG NLWDLLERLD KQGCQRYVVT 190 200 210 220 230 240 DVERGGMMSS PNFTLLQEVC AKTSSPVIAG GGVSSLDDLR ALADLSTIGV EGAILGQALH 250 IGKVPLEDAL AATQSPRR

References

[1]

"The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens." Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A., Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F., Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C., Lanois A., Powell K. , Siguier P., Vincent R., Wingate V., Zouine M., Glaser P., Boemare N., Danchin A., Kunst F. Nat. Biotechnol. 21:1307-1313(2003) [PubMed: 14528314] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TT01.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX571861 Genomic DNA. Translation: CAE13092.1.
RefSeq	NP_928142.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2800760.
GenomeReviews	Gene locus plu0797 in contig BX470251_GR.
KEGG	plu:plu0797.
NMPDR	fig|243265.1.peg.766.
Organism-specific databases
PhotoList	plu0797.
CMR	Search...
Phylogenomic databases
HOGENOM	Q7N8D1.
OMA	Q7N8D1. CARYVVT.
Enzyme and pathway databases
BioCyc	PLUM243265:PLU0797-MON.
BRENDA	5.3.1.16. 308689.
Family and domain databases
HAMAP	MF_01014. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR006062. His_biosynth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00977. His_biosynth. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS42_PHOLL

Accession

Primary (citable) accession number: Q7N8D1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	December 15, 2003
Last modified:	June 16, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)