SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q7N8D1

- HIS42_PHOLL

UniProt

Q7N8D1 - HIS42_PHOLL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2
Gene
hisA2, plu0797
Organism
Photorhabdus luminescens subsp. laumondii (strain TT01)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei14 – 141Proton acceptor By similarity
Active sitei140 – 1401Proton donor By similarity

GO - Molecular functioni

  1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00031; UER00009.

Names & Taxonomyi

Protein namesi
Recommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2 (EC:5.3.1.16)
Alternative name(s):
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase 2
Gene namesi
Name:hisA2
Ordered Locus Names:plu0797
OrganismiPhotorhabdus luminescens subsp. laumondii (strain TT01)
Taxonomic identifieri243265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
ProteomesiUP000002514: Chromosome

Organism-specific databases

GenoListiplu0797.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2582581-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2UniRule annotation
PRO_0000142032Add
BLAST

Proteomic databases

PRIDEiQ7N8D1.

Interactioni

Protein-protein interaction databases

STRINGi243265.plu0797.

Structurei

3D structure databases

ProteinModelPortaliQ7N8D1.

Family & Domainsi

Sequence similaritiesi

Belongs to the HisA/HisF family.

Phylogenomic databases

eggNOGiCOG0106.
HOGENOMiHOG000224614.
KOiK01814.
K01817.
OMAiNAGAKWI.
OrthoDBiEOG6H1Q3W.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01014. HisA.
InterProiIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7N8D1-1 [UniParc]FASTAAdd to Basket

« Hide

MISKETFEIF PSVDIVDGIA MTSNSAIRLT RGESSTLRRP LGTPAEVALA    50
WQNAGAKWIH VVDLDAASGR GSNSHLIADV LAAVDINVQV CGGIRDETIL 100
RKVLATGCQR VNLGTAALEN PDWCAQAIAE YGDKIAIALD VKSTSEGYQL 150
ATHGWNVSKG NLWDLLERLD KQGCQRYVVT DVERGGMMSS PNFTLLQEVC 200
AKTSSPVIAG GGVSSLDDLR ALADLSTIGV EGAILGQALH IGKVPLEDAL 250
AATQSPRR 258
Length:258
Mass (Da):27,350
Last modified:December 15, 2003 - v1
Checksum:i0D890FE0FC66E410
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571861 Genomic DNA. Translation: CAE13092.1.
RefSeqiNP_928142.1. NC_005126.1.
WP_011145171.1. NC_005126.1.

Genome annotation databases

EnsemblBacteriaiCAE13092; CAE13092; plu0797.
GeneIDi2800760.
KEGGiplu:plu0797.
PATRICi20505205. VBIPhoLum48522_0876.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571861 Genomic DNA. Translation: CAE13092.1 .
RefSeqi NP_928142.1. NC_005126.1.
WP_011145171.1. NC_005126.1.

3D structure databases

ProteinModelPortali Q7N8D1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243265.plu0797.

Proteomic databases

PRIDEi Q7N8D1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE13092 ; CAE13092 ; plu0797 .
GeneIDi 2800760.
KEGGi plu:plu0797.
PATRICi 20505205. VBIPhoLum48522_0876.

Organism-specific databases

GenoListi plu0797.

Phylogenomic databases

eggNOGi COG0106.
HOGENOMi HOG000224614.
KOi K01814.
K01817.
OMAi NAGAKWI.
OrthoDBi EOG6H1Q3W.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00009 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01014. HisA.
InterProi IPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00977. His_biosynth. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TT01.

Entry informationi

Entry nameiHIS42_PHOLL
AccessioniPrimary (citable) accession number: Q7N8D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3