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Q7N845

- GSA_PHOLL

UniProt

Q7N845 - GSA_PHOLL

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Protein
Glutamate-1-semialdehyde 2,1-aminomutase
Gene
hemL, plu0902
Organism
Photorhabdus luminescens subsp. laumondii (strain TT01)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:plu0902
OrganismiPhotorhabdus luminescens subsp. laumondii (strain TT01)
Taxonomic identifieri243265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
ProteomesiUP000002514: Chromosome

Organism-specific databases

GenoListiplu0902.

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation
PRO_0000120430Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei265 – 2651N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiQ7N845.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243265.plu0902.

Structurei

3D structure databases

ProteinModelPortaliQ7N845.
SMRiQ7N845. Positions 3-420.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiRAIKPYP.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7N845-1 [UniParc]FASTAAdd to Basket

« Hide

MSQSDILYSQ AKQLIPGGVN SPVRAFNGVG GTPLFIKHAD GAYLYDVDGK    50
AYIDYVGSWG PMVLGHNHSA IRNAVIKAAE QGLSFGAPTA AEVEMAQLVT 100
ELVPSMDMVR MVNSGTEATM SAIRLARGYT HRDKIIKFEG CYHGHADCLL 150
VKAGSGALTI GQPNSPGVPV DFVKHTLTCT YNDLSSVREA FEQYPQEIAC 200
IIVEPVAGNM NCVPPQPEFL PGLRALCDEF GALLIIDEVM TGFRVALSGA 250
QSYYDVEPDI TCLGKIIGGG MPVGAFGGRY EVMEKLAPIG PVYQAGTLSG 300
NPIAMAAGLA CLKEVSQPGV HQRLTELTDN LAAGLTKSAK AANIPLVVNH 350
VGGMFGIFFT DAETVTCYQD VMNCDIERFK HFFHLMLDEG VYLAPSAFEA 400
GFMSIAHTDE DIQRTVNAAA RCFAKLK 427
Length:427
Mass (Da):45,710
Last modified:December 15, 2003 - v1
Checksum:i48B9A87C545C2386
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571861 Genomic DNA. Translation: CAE13197.1.
RefSeqiNP_928238.1. NC_005126.1.
WP_011145267.1. NC_005126.1.

Genome annotation databases

EnsemblBacteriaiCAE13197; CAE13197; plu0902.
GeneIDi2800865.
KEGGiplu:plu0902.
PATRICi20505439. VBIPhoLum48522_0993.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571861 Genomic DNA. Translation: CAE13197.1 .
RefSeqi NP_928238.1. NC_005126.1.
WP_011145267.1. NC_005126.1.

3D structure databases

ProteinModelPortali Q7N845.
SMRi Q7N845. Positions 3-420.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243265.plu0902.

Proteomic databases

PRIDEi Q7N845.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE13197 ; CAE13197 ; plu0902 .
GeneIDi 2800865.
KEGGi plu:plu0902.
PATRICi 20505439. VBIPhoLum48522_0993.

Organism-specific databases

GenoListi plu0902.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi RAIKPYP.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TT01.

Entry informationi

Entry nameiGSA_PHOLL
AccessioniPrimary (citable) accession number: Q7N845
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: December 15, 2003
Last modified: September 3, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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