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Reviewed, UniProtKB/Swiss-Prot Q7N7A4 (GSH1_PHOLL)

Last modified June 16, 2009. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Glutamate--cysteine ligase
    EC=6.3.2.2
Alternative name(s):
    Gamma-glutamylcysteine synthetase
    Gamma-ECS
      Short name=GCS
Gene names
Name: gshA
Ordered Locus Names: plu1252
OrganismPhotorhabdus luminescens subsp. laumondii [Complete proteome] [HAMAP]
Taxonomic identifier141679 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus

Protein attributes

Sequence length519 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine. HAMAP MF_00578

Pathway

Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. HAMAP MF_00578

Sequence similarities

Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.

Ontologies

Keywords
   Biological processGlutathione biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglutathione biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutamate-cysteine ligase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 519519Glutamate--cysteine ligase HAMAP MF_00578
PRO_0000192530

Sequences

Sequence LengthMass (Da)Tools
Q7N7A4-1 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 4F478A73A07BB2C0

FASTA51958,738
        10         20         30         40         50         60 
MIPDVSRALS WLEAHPTILK GIRRGVERET LRITSDGSLA ITEHPKTLGA ALTHKWITTD 

        70         80         90        100        110        120 
FAESLLEFIT PAGDDIKYTI SFLSDIHRHT ARVLDKEKMW PLSMPCFIDA EENITLAQYG 

       130        140        150        160        170        180 
ASNVGRYKTL YREGLKNRYG ALMQTISGVH YNFSLPIEFW RAWVGVEDAE SGKEQISNGY 

       190        200        210        220        230        240 
FRLIRNYYRF GWVIPYLFGA SPAICSSFLR GRETSFLFER TEDGTCYLPY ATSLRMSNLG 

       250        260        270        280        290        300 
YTNKSQSDLN ITFNNLHTYI DGLKKAIHKP SDEFAKLGTK QGDKHIQLNT NVLQIENELY 

       310        320        330        340        350        360 
APIRPKRVTR GNESPSDALL RGGVEYIEVR SLDINPFAAI GVNETQIRFL DLFLIWCVLA 

       370        380        390        400        410        420 
EAPEMGSDEL DCCRKNWNRV ILEGRKPGQM IGLGCGSVEE PLAKVGKKLF SDLKRVAAIL 

       430        440        450        460        470        480 
DSCSGTQYQK VCEELIATFD DSSLTLSARV LEKMKSQGIG GFGLELADEY HQQLISEKYE 

       490        500        510 
VISDEQFAIE RRASVERQDA LEREDTMSFD EYLKQQTGC 

« Hide

Cross-references

Sequence databases

BX571863 Genomic DNA. Translation: CAE13546.1.
RefSeqNP_928563.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID2801220.
GenomeReviewsGene locus plu1252 in contig BX470251_GR.
KEGGplu:plu1252.
NMPDRfig|243265.1.peg.1187.

Organism-specific databases

PhotoListplu1252.
CMRSearch...

Phylogenomic databases

HOGENOMQ7N7A4.
OMAQ7N7A4. EYIEVRA.

Enzyme and pathway databases

BioCycPLUM243265:PLU1252-MON.
BRENDA6.3.2.2. 308689.

Family and domain databases

HAMAPMF_00578.
[Tree]
InterProIPR007370. Glu_cys_ligase.
IPR006334. Glut_cys_ligase.
[Graphical view]
PfamPF04262. Glu_cys_ligase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01434. glu_cys_ligase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGSH1_PHOLL
AccessionPrimary (citable) accession number: Q7N7A4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: December 15, 2003
Last modified: June 16, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents