Q7N7A4 (GSH1_PHOLL) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 50.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Glutamate--cysteine ligase EC=6.3.2.2 Alternative name(s): Gamma-ECS Short name=GCS Gamma-glutamylcysteine synthetase | ||||
| Gene names |
| ||||
| Organism | Photorhabdus luminescens subsp. laumondii (strain TT01) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 243265 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Photorhabdus |
Protein attributes
| Sequence length | 519 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine. HAMAP MF_00578 |
| Pathway | Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. HAMAP MF_00578 |
| Sequence similarities | Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glutathione biosynthesis |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | glutathione biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glutamate-cysteine ligase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 519 | 519 | Glutamate--cysteine ligase HAMAP MF_00578 | PRO_0000192530 | |||
Sequences
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References
| [1] | "The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens." Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A., Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F., Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C., Lanois A., Powell K. Kunst F.Nat. Biotechnol. 21:1307-1313(2003) [PubMed: 14528314] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TT01. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BX571863 Genomic DNA. Translation: CAE13546.1. |
| RefSeq | NP_928563.1. NC_005126.1. |
3D structure databases | |
| ProteinModelPortal | Q7N7A4. |
| SMR | Q7N7A4. Positions 1-502. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 2801220. |
| GenomeReviews | Gene locus plu1252 in contig BX470251_GR. |
| KEGG | plu:plu1252. |
| NMPDR | fig|243265.1.peg.1187. |
| PATRIC | 20506225. VBIPhoLum48522_1382. |
Organism-specific databases | |
| GenoList | plu1252. |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG289023. |
| OMA | FGLIRNY. |
| PhylomeDB | Q7N7A4. |
| ProtClustDB | PRK02107. |
Enzyme and pathway databases | |
| BioCyc | PLUM243265:PLU1252-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00578. Glu_cys_ligase. [Tree] |
| InterPro | IPR007370. Glu_cys_ligase. IPR006334. Glut_cys_ligase. [Graphical view] |
| KO | K01919. |
| Pfam | PF04262. Glu_cys_ligase. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01434. Glu_cys_ligase. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | GSH1_PHOLL | ||||||||
| Accession | Primary (citable) accession number: Q7N7A4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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