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Q7N755

- SYL_PHOLL

UniProt

Q7N755 - SYL_PHOLL

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Photorhabdus luminescens subsp. laumondii (strain TT01)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei622 – 6221ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:plu1303
    OrganismiPhotorhabdus luminescens subsp. laumondii (strain TT01)
    Taxonomic identifieri243265 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
    ProteomesiUP000002514: Chromosome

    Organism-specific databases

    GenoListiplu1303.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 860860Leucine--tRNA ligasePRO_0000152060Add
    BLAST

    Proteomic databases

    PRIDEiQ7N755.

    Interactioni

    Protein-protein interaction databases

    STRINGi243265.plu1303.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7N755.
    SMRiQ7N755. Positions 228-413.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi619 – 6235"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7N755-1 [UniParc]FASTAAdd to Basket

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    MQEQYRPEDI EPQVQLHWQE KQTFKVTEDN SKEKYYCLSM LPYPSGRLHM    50
    GHVRNYTIGD VISRYQRMLG KNVLQPIGWD AFGLPAEGAA VKNNTAPAPW 100
    TYANIEYMKG QLKTLGFGYD WDREVTTCTP EYYHWEQWFF TKLYEKGLVY 150
    KKTSSVNWCP HDLTVLANEQ VVDGCCWRCD SKVERKEIPQ WFIKITDYAE 200
    ELLSDLETLE EWPEQVKTMQ RNWIGRSEGV EITFDVADSQ EKLTVYTTRP 250
    DTFLGATYVA IAAGHPLAKQ AAENNPELVA FIDECRNTKV AEADMATMEK 300
    KGMATGMFAI HSLTKEKVAI WVANFVLMEY GTGAVMAVPG HDQRDWEFAT 350
    KYNLPIKAVI LDNEGNEPNV HEAPVTDKNI LFNSGEFSGL NHEAGFNAIA 400
    NKLVEMGVGK RKVNYRLRDW GVSRQRYWGA PIPMATLENG TVVPVPADQL 450
    PVILPEDVKM DGITSPIKAD PEWAKTTING QPALRETDTF DTFMESSWYY 500
    ARYTCPDYDK GLLDPAAANY WLPVDQYIGG IEHAIMHLMY FRFFHKLMRD 550
    ASLVNSNEPA KRLLCQGMVL ADAFYYIGKN GEKIWVSPAD TIVERDDKGR 600
    IVKATDKEGH ELVYTGMSKM SKSKNNGIDP QLMVEKYGAD TVRLFMMFAA 650
    PPELTLEWQE SSVEGANRFL KRVWRLVYEH SSKGATQPLD ITNLTVEQKD 700
    LFRDLHKTIA KVTDDVGRRQ AFNTAIAAVM ELMNKLTRAP QETEQDRALM 750
    QEALLAVVRM LSPITPHACF IMWQALGGEG GIDTADWPQA NEQAMVDDTK 800
    LVVIQVNGKV RGRVTVPADA TKEYVHDLAA QEYGVAKYLE GVTIRKVIYV 850
    PGKLLNLVVG 860
    Length:860
    Mass (Da):97,477
    Last modified:December 15, 2003 - v1
    Checksum:iDE27BF0415985200
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571863 Genomic DNA. Translation: CAE13597.1.
    RefSeqiNP_928614.1. NC_005126.1.
    WP_011145627.1. NC_005126.1.

    Genome annotation databases

    EnsemblBacteriaiCAE13597; CAE13597; plu1303.
    GeneIDi2801276.
    KEGGiplu:plu1303.
    PATRICi20506341. VBIPhoLum48522_1435.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571863 Genomic DNA. Translation: CAE13597.1 .
    RefSeqi NP_928614.1. NC_005126.1.
    WP_011145627.1. NC_005126.1.

    3D structure databases

    ProteinModelPortali Q7N755.
    SMRi Q7N755. Positions 228-413.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243265.plu1303.

    Proteomic databases

    PRIDEi Q7N755.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE13597 ; CAE13597 ; plu1303 .
    GeneIDi 2801276.
    KEGGi plu:plu1303.
    PATRICi 20506341. VBIPhoLum48522_1435.

    Organism-specific databases

    GenoListi plu1303.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TT01.

    Entry informationi

    Entry nameiSYL_PHOLL
    AccessioniPrimary (citable) accession number: Q7N755
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3