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Q7N755

- SYL_PHOLL

UniProt

Q7N755 - SYL_PHOLL

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Protein

Leucine--tRNA ligase

Gene
leuS, plu1303
Organism
Photorhabdus luminescens subsp. laumondii (strain TT01)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei622 – 6221ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:plu1303
OrganismiPhotorhabdus luminescens subsp. laumondii (strain TT01)
Taxonomic identifieri243265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
ProteomesiUP000002514: Chromosome

Organism-specific databases

GenoListiplu1303.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 860860Leucine--tRNA ligaseUniRule annotationPRO_0000152060Add
BLAST

Proteomic databases

PRIDEiQ7N755.

Interactioni

Protein-protein interaction databases

STRINGi243265.plu1303.

Structurei

3D structure databases

ProteinModelPortaliQ7N755.
SMRiQ7N755. Positions 228-413.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi619 – 6235"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7N755-1 [UniParc]FASTAAdd to Basket

« Hide

MQEQYRPEDI EPQVQLHWQE KQTFKVTEDN SKEKYYCLSM LPYPSGRLHM    50
GHVRNYTIGD VISRYQRMLG KNVLQPIGWD AFGLPAEGAA VKNNTAPAPW 100
TYANIEYMKG QLKTLGFGYD WDREVTTCTP EYYHWEQWFF TKLYEKGLVY 150
KKTSSVNWCP HDLTVLANEQ VVDGCCWRCD SKVERKEIPQ WFIKITDYAE 200
ELLSDLETLE EWPEQVKTMQ RNWIGRSEGV EITFDVADSQ EKLTVYTTRP 250
DTFLGATYVA IAAGHPLAKQ AAENNPELVA FIDECRNTKV AEADMATMEK 300
KGMATGMFAI HSLTKEKVAI WVANFVLMEY GTGAVMAVPG HDQRDWEFAT 350
KYNLPIKAVI LDNEGNEPNV HEAPVTDKNI LFNSGEFSGL NHEAGFNAIA 400
NKLVEMGVGK RKVNYRLRDW GVSRQRYWGA PIPMATLENG TVVPVPADQL 450
PVILPEDVKM DGITSPIKAD PEWAKTTING QPALRETDTF DTFMESSWYY 500
ARYTCPDYDK GLLDPAAANY WLPVDQYIGG IEHAIMHLMY FRFFHKLMRD 550
ASLVNSNEPA KRLLCQGMVL ADAFYYIGKN GEKIWVSPAD TIVERDDKGR 600
IVKATDKEGH ELVYTGMSKM SKSKNNGIDP QLMVEKYGAD TVRLFMMFAA 650
PPELTLEWQE SSVEGANRFL KRVWRLVYEH SSKGATQPLD ITNLTVEQKD 700
LFRDLHKTIA KVTDDVGRRQ AFNTAIAAVM ELMNKLTRAP QETEQDRALM 750
QEALLAVVRM LSPITPHACF IMWQALGGEG GIDTADWPQA NEQAMVDDTK 800
LVVIQVNGKV RGRVTVPADA TKEYVHDLAA QEYGVAKYLE GVTIRKVIYV 850
PGKLLNLVVG 860
Length:860
Mass (Da):97,477
Last modified:December 15, 2003 - v1
Checksum:iDE27BF0415985200
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571863 Genomic DNA. Translation: CAE13597.1.
RefSeqiNP_928614.1. NC_005126.1.
WP_011145627.1. NC_005126.1.

Genome annotation databases

EnsemblBacteriaiCAE13597; CAE13597; plu1303.
GeneIDi2801276.
KEGGiplu:plu1303.
PATRICi20506341. VBIPhoLum48522_1435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571863 Genomic DNA. Translation: CAE13597.1 .
RefSeqi NP_928614.1. NC_005126.1.
WP_011145627.1. NC_005126.1.

3D structure databases

ProteinModelPortali Q7N755.
SMRi Q7N755. Positions 228-413.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243265.plu1303.

Proteomic databases

PRIDEi Q7N755.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE13597 ; CAE13597 ; plu1303 .
GeneIDi 2801276.
KEGGi plu:plu1303.
PATRICi 20506341. VBIPhoLum48522_1435.

Organism-specific databases

GenoListi plu1303.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TT01.

Entry informationi

Entry nameiSYL_PHOLL
AccessioniPrimary (citable) accession number: Q7N755
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: December 15, 2003
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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