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Q7N755 (SYL_PHOLL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:plu1303
OrganismPhotorhabdus luminescens subsp. laumondii (strain TT01) [Complete proteome] [HAMAP]
Taxonomic identifier243265 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus

Protein attributes

Sequence length860 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 860860Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000152060

Regions

Motif42 – 5211"HIGH" region HAMAP-Rule MF_00049
Motif619 – 6235"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6221ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7N755 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: DE27BF0415985200

FASTA86097,477
        10         20         30         40         50         60 
MQEQYRPEDI EPQVQLHWQE KQTFKVTEDN SKEKYYCLSM LPYPSGRLHM GHVRNYTIGD 

        70         80         90        100        110        120 
VISRYQRMLG KNVLQPIGWD AFGLPAEGAA VKNNTAPAPW TYANIEYMKG QLKTLGFGYD 

       130        140        150        160        170        180 
WDREVTTCTP EYYHWEQWFF TKLYEKGLVY KKTSSVNWCP HDLTVLANEQ VVDGCCWRCD 

       190        200        210        220        230        240 
SKVERKEIPQ WFIKITDYAE ELLSDLETLE EWPEQVKTMQ RNWIGRSEGV EITFDVADSQ 

       250        260        270        280        290        300 
EKLTVYTTRP DTFLGATYVA IAAGHPLAKQ AAENNPELVA FIDECRNTKV AEADMATMEK 

       310        320        330        340        350        360 
KGMATGMFAI HSLTKEKVAI WVANFVLMEY GTGAVMAVPG HDQRDWEFAT KYNLPIKAVI 

       370        380        390        400        410        420 
LDNEGNEPNV HEAPVTDKNI LFNSGEFSGL NHEAGFNAIA NKLVEMGVGK RKVNYRLRDW 

       430        440        450        460        470        480 
GVSRQRYWGA PIPMATLENG TVVPVPADQL PVILPEDVKM DGITSPIKAD PEWAKTTING 

       490        500        510        520        530        540 
QPALRETDTF DTFMESSWYY ARYTCPDYDK GLLDPAAANY WLPVDQYIGG IEHAIMHLMY 

       550        560        570        580        590        600 
FRFFHKLMRD ASLVNSNEPA KRLLCQGMVL ADAFYYIGKN GEKIWVSPAD TIVERDDKGR 

       610        620        630        640        650        660 
IVKATDKEGH ELVYTGMSKM SKSKNNGIDP QLMVEKYGAD TVRLFMMFAA PPELTLEWQE 

       670        680        690        700        710        720 
SSVEGANRFL KRVWRLVYEH SSKGATQPLD ITNLTVEQKD LFRDLHKTIA KVTDDVGRRQ 

       730        740        750        760        770        780 
AFNTAIAAVM ELMNKLTRAP QETEQDRALM QEALLAVVRM LSPITPHACF IMWQALGGEG 

       790        800        810        820        830        840 
GIDTADWPQA NEQAMVDDTK LVVIQVNGKV RGRVTVPADA TKEYVHDLAA QEYGVAKYLE 

       850        860 
GVTIRKVIYV PGKLLNLVVG 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571863 Genomic DNA. Translation: CAE13597.1.
RefSeqNP_928614.1. NC_005126.1.

3D structure databases

ProteinModelPortalQ7N755.
SMRQ7N755. Positions 228-413.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243265.plu1303.

Proteomic databases

PRIDEQ7N755.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE13597; CAE13597; plu1303.
GeneID2801276.
KEGGplu:plu1303.
PATRIC20506341. VBIPhoLum48522_1435.

Organism-specific databases

GenoListplu1303.
CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAHISHELW.
OrthoDBEOG63Z74X.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_PHOLL
AccessionPrimary (citable) accession number: Q7N755
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: December 15, 2003
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries