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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.UniRule annotation

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

BioCyciPLUM243265:G1GTE-1531-MONOMER
UniPathwayiUPA00115; UER00409

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonaseUniRule annotation (EC:3.1.1.31UniRule annotation)
Short name:
6-P-gluconolactonaseUniRule annotation
Gene namesi
Name:pglUniRule annotation
Ordered Locus Names:plu1480
OrganismiPhotorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Taxonomic identifieri243265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaePhotorhabdus
Proteomesi
  • UP000002514 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001711361 – 3286-phosphogluconolactonaseAdd BLAST328

Interactioni

Protein-protein interaction databases

STRINGi243265.plu1480

Structurei

3D structure databases

ProteinModelPortaliQ7N6R1
SMRiQ7N6R1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cycloisomerase 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105HHQ Bacteria
COG2706 LUCA
HOGENOMiHOG000257418
KOiK07404
OMAiEGNWPRD
OrthoDBiPOG091H07R3

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_01605 6P_gluconolactonase, 1 hit
InterProiView protein in InterPro
IPR022528 6-phosphogluconolactonase_YbhE
IPR019405 Lactonase_7-beta_prop
IPR011045 N2O_reductase_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF10282 Lactonase, 1 hit
SUPFAMiSSF50974 SSF50974, 1 hit

Sequencei

Sequence statusi: Complete.

Q7N6R1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQVVYTASP NSCQIHVWSL NNEGELSLIQ TVDVPGEVQP MVVSPDRKHL
60 70 80 90 100
YVGIRPQFSI VTYQIGSRGE LAQQGISSIP GSPTHISTDK QGRFLFSASY
110 120 130 140 150
SYNNLSVSLI DDQGIVGEPV QVIAGLQAPH SANIDWDNKQ LLVPCLKEDR
160 170 180 190 200
VRIFEMAKEG YLTEKRAEEI TTAMGAGPRH MAFHPNQQVI YCINELDSTV
210 220 230 240 250
DVYRKWEKYR TVQTVDSLPA DLAGVRWSAD IHITPDGRHL YTSERTSSLI
260 270 280 290 300
SHFVISQDGS NLTLAGHYKT EIQPRGFAID HSGKYLIASG QKSDHISVSS
310 320
IDKYTGKLTE LTRYPVGKGP MWVTVLAL
Length:328
Mass (Da):36,427
Last modified:December 15, 2003 - v1
Checksum:i5B09687ABA289EB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571864 Genomic DNA Translation: CAE13773.1
RefSeqiWP_011145783.1, NC_005126.1

Genome annotation databases

EnsemblBacteriaiCAE13773; CAE13773; plu1480
KEGGiplu:plu1480

Similar proteinsi

Entry informationi

Entry namei6PGL_PHOLL
AccessioniPrimary (citable) accession number: Q7N6R1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: December 15, 2003
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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