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Q7N6K7 (GCH1_PHOLL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:plu1543
OrganismPhotorhabdus luminescens subsp. laumondii (strain TT01) [Complete proteome] [HAMAP]
Taxonomic identifier243265 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 219219GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_0000119426

Sites

Metal binding1091Zinc By similarity
Metal binding1121Zinc By similarity
Metal binding1801Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7N6K7 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: 2839165A67421208

FASTA21924,602
        10         20         30         40         50         60 
MSSLSKEAEL VHSALETRGL ETPLRGQALV PEVRKARIEE HMTEVMKLLN LDLRDDSLAE 

        70         80         90        100        110        120 
TPGRIAKMYV DEIFSGLDYS NFPKITLIEN KMKVDEMVTV RDITLTSTCE HHFVTIDGKA 

       130        140        150        160        170        180 
TVAYIPKDKV IGLSKINRIV QFFSQRPQVQ ERLTQQILIA LQTLLGTNNV AVSIDAVHYC 

       190        200        210 
VKARGIRDAT STTTTTSLGG LFKSSQNTRQ EFLRTTRHV 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571864 Genomic DNA. Translation: CAE13836.1.
RefSeqNP_928834.1. NC_005126.1.

3D structure databases

ProteinModelPortalQ7N6K7.
SMRQ7N6K7. Positions 3-218.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243265.plu1543.

Proteomic databases

PRIDEQ7N6K7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE13836; CAE13836; plu1543.
GeneID2801538.
KEGGplu:plu1543.
PATRIC20506957. VBIPhoLum48522_1721.

Organism-specific databases

GenoListplu1543.
CMRSearch...

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMAVQFFSSR.
OrthoDBEOG6XHC8G.

Enzyme and pathway databases

UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_PHOLL
AccessionPrimary (citable) accession number: Q7N6K7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: December 15, 2003
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways