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Q7N6K4 (MAO1_PHOLL) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NAD-dependent malic enzyme
Short name=NAD-ME
EC=1.1.1.38
Gene names
Name:maeA
Ordered Locus Names:plu1546
OrganismPhotorhabdus luminescens subsp. laumondii (strain TT01) [Complete proteome] [HAMAP]
Taxonomic identifier243265 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Photorhabdus

Protein attributes

Sequence length565 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-malate + NAD+ = pyruvate + CO2 + NADH. HAMAP MF_01619

Cofactor

Divalent metal cations. Prefers magnesium or manganese By similarity.

Subunit structure

Homotetramer By similarity. HAMAP MF_01619

Sequence similarities

Belongs to the malic enzymes family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 565565NAD-dependent malic enzyme HAMAP MF_01619
PRO_0000160220

Sites

Active site1041Proton donor By similarity
Active site1751Proton acceptor By similarity
Metal binding2461Divalent metal cation By similarity
Metal binding2471Divalent metal cation By similarity
Metal binding2701Divalent metal cation By similarity
Binding site1571NAD By similarity
Binding site2701NAD By similarity
Binding site4181NAD By similarity
Site2701Important for activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7N6K4 [UniParc].

Last modified December 15, 2003. Version 1.
Checksum: F15FE165CCAC9CC7

FASTA56563,000
        10         20         30         40         50         60 
MELEHESKRP LYIPYSGPIL LEFPLLNKGS AFTEEERRNF NLHGLLPEAV ETIEEQAERA 

        70         80         90        100        110        120 
YRQYLDFKND ADKHIYLRNI QDTNETLFYR LLDAHLNEMM PIIYTPTVGE ACEHFSDIYR 

       130        140        150        160        170        180 
RARGLFISHP NKAHIDDMLQ NATKQNVKVI VVTDGERILG LGDQGIGGMG IPIGKLSLYT 

       190        200        210        220        230        240 
SCGGISPAYT LPVVLDVGTN NPQRLNDPLY MGWRHPRITG KEYDEFVDEF IQAVKRRWPN 

       250        260        270        280        290        300 
VLLQFEDFAQ KNAMPLLNRY RHEICCFNDD IQGTAAVTLG SLIAASRAAG RQLKDQTVTF 

       310        320        330        340        350        360 
LGAGSAGCGI AEQIVAQMKS EGLSDEQARA RIFMVDRFGL LTDKLPNLLD FQNKLVQKSS 

       370        380        390        400        410        420 
SLAKWDVNND SISLLDVVRN AKPTVLIGVS GQAGLFTEEI IREMHKHCER PIVMPLSNPT 

       430        440        450        460        470        480 
SRVEARPEDI INWTDGAALV ATGSPFNPVK YKDQEYPIAQ CNNAYIFPGI GLGVIASGAK 

       490        500        510        520        530        540 
LVTDGMLMAA SRTLANCSPL AQEGQGPLLP LIDDIQEVSR KIAKQVAKEA QIQGVATVTS 

       550        560 
DGALDEAIER NFWKPEYRVY KRTSF

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX571864 Genomic DNA. Translation: CAE13839.1.
RefSeqNP_928837.1. NC_005126.1.

3D structure databases

ProteinModelPortalQ7N6K4.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2801541.
GenomeReviewsGene locus plu1546 in contig BX470251_GR.
KEGGplu:plu1546.
NMPDRfig|243265.1.peg.1461.
PATRIC20506967. VBIPhoLum48522_1726.

Organism-specific databases

GenoListplu1546.
CMRSearch...

Phylogenomic databases

HOGENOMHBG289821.
OMAQDNNETL.
PhylomeDBQ7N6K4.
ProtClustDBPRK13529.

Enzyme and pathway databases

BioCycPLUM243265:PLU1546-MONOMER.

Family and domain databases

HAMAPMF_01619. NAD_malic_enz.
[Tree]
InterProIPR015884. Malic_enzyme_CS.
IPR012301. Malic_N.
IPR012302. Malic_NAD-bd.
IPR001891. Malic_OxRdtase.
IPR016040. NAD(P)-bd_dom.
IPR023667. NAD_malic_enz_proteobac.
[Graphical view]
Gene3DG3DSA:3.40.50.10380. G3DSA:3.40.50.10380. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00027.
PfamPF00390. malic. 1 hit.
PF03949. Malic_M. 1 hit.
[Graphical view]
PIRSFPIRSF000106. ME. 1 hit.
PRINTSPR00072. MALOXRDTASE.
SMARTSM00919. Malic_M. 1 hit.
[Graphical view]
PROSITEPS00331. MALIC_ENZYMES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMAO1_PHOLL
AccessionPrimary (citable) accession number: Q7N6K4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 15, 2003
Last modified: January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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