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Q7N6K3

- CDD_PHOLL

UniProt

Q7N6K3 - CDD_PHOLL

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Protein
Cytidine deaminase
Gene
cdd, plu1547
Organism
Photorhabdus luminescens subsp. laumondii (strain TT01)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.UniRule annotation

Catalytic activityi

Cytidine + H2O = uridine + NH3.UniRule annotation
2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.UniRule annotation

Cofactori

Binds 1 zinc ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi102 – 1021Zinc; catalytic By similarity
Active sitei104 – 1041Proton donor By similarity
Metal bindingi129 – 1291Zinc; catalytic By similarity
Metal bindingi132 – 1321Zinc; catalytic By similarity

GO - Molecular functioni

  1. cytidine deaminase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytidine deaminase (EC:3.5.4.5)
    Alternative name(s):
    Cytidine aminohydrolase
    Short name:
    CDA
    Gene namesi
    Name:cdd
    Ordered Locus Names:plu1547
    OrganismiPhotorhabdus luminescens subsp. laumondii (strain TT01)
    Taxonomic identifieri243265 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePhotorhabdus
    ProteomesiUP000002514: Chromosome

    Organism-specific databases

    GenoListiplu1547.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 294294Cytidine deaminaseUniRule annotation
    PRO_0000171658Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer By similarity.UniRule annotation

    Protein-protein interaction databases

    STRINGi243265.plu1547.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7N6K3.
    SMRiQ7N6K3. Positions 1-290.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini59 – 14082CMP/dCMP deaminase zinc-binding
    Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni89 – 913Substrate binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0295.
    HOGENOMiHOG000218617.
    KOiK01489.
    OMAiNRSHAPY.
    OrthoDBiEOG6XDH25.

    Family and domain databases

    HAMAPiMF_01558. Cyt_deam.
    InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR013171. Cyd/dCyd_deaminase_Zn-bd.
    IPR006263. Cyt_deam_dimer.
    IPR016193. Cytidine_deaminase-like.
    IPR020797. Cytidine_deaminase_bacteria.
    [Graphical view]
    PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
    PF08211. dCMP_cyt_deam_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006334. Cdd_plus_pseudo. 1 hit.
    SUPFAMiSSF53927. SSF53927. 2 hits.
    TIGRFAMsiTIGR01355. cyt_deam_dimer. 1 hit.
    PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7N6K3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQARFHPIWV QLPSKLQDAL LPYAGNDDFP AMLTAEQAKS IKKACGFDDN    50
    TLAVALLPLA AASSLTPISH FNVGAIARGE SGNLYFGANM EFAGVPLQQT 100
    IHAEQCAITH AWLLGEKRLA SVTVNYSPCG HCRQFMNELN SGTQLEIHLP 150
    KQASSTLDHY LPDSFGPNDL GITTLLMDPV NHGYKLETTD KLVLTALDAA 200
    NQSYAPYSNS YSGTALLGKD GIIYPGRYAE NAAFNPSLPP LQAALILMNI 250
    SGGDCLAIER AVLVEGKHSD LSQRSATQSI LAALGCSKFD YYTF 294
    Length:294
    Mass (Da):31,667
    Last modified:December 15, 2003 - v1
    Checksum:i56E5C47A2A5B9766
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571864 Genomic DNA. Translation: CAE13840.1.
    RefSeqiNP_928838.1. NC_005126.1.

    Genome annotation databases

    EnsemblBacteriaiCAE13840; CAE13840; plu1547.
    GeneIDi2801542.
    KEGGiplu:plu1547.
    PATRICi20506969. VBIPhoLum48522_1727.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571864 Genomic DNA. Translation: CAE13840.1 .
    RefSeqi NP_928838.1. NC_005126.1.

    3D structure databases

    ProteinModelPortali Q7N6K3.
    SMRi Q7N6K3. Positions 1-290.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 243265.plu1547.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE13840 ; CAE13840 ; plu1547 .
    GeneIDi 2801542.
    KEGGi plu:plu1547.
    PATRICi 20506969. VBIPhoLum48522_1727.

    Organism-specific databases

    GenoListi plu1547.

    Phylogenomic databases

    eggNOGi COG0295.
    HOGENOMi HOG000218617.
    KOi K01489.
    OMAi NRSHAPY.
    OrthoDBi EOG6XDH25.

    Family and domain databases

    HAMAPi MF_01558. Cyt_deam.
    InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR013171. Cyd/dCyd_deaminase_Zn-bd.
    IPR006263. Cyt_deam_dimer.
    IPR016193. Cytidine_deaminase-like.
    IPR020797. Cytidine_deaminase_bacteria.
    [Graphical view ]
    Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
    PF08211. dCMP_cyt_deam_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006334. Cdd_plus_pseudo. 1 hit.
    SUPFAMi SSF53927. SSF53927. 2 hits.
    TIGRFAMsi TIGR01355. cyt_deam_dimer. 1 hit.
    PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TT01.

    Entry informationi

    Entry nameiCDD_PHOLL
    AccessioniPrimary (citable) accession number: Q7N6K3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: December 15, 2003
    Last modified: May 14, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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